Antiviral Compositions and Methods of Use

This invention is related to isolation of two highly potent, non-toxic inhibitors against human immunodeficiency virus type 1 (HIV-1) integrase and viral replication. Two water soluble compounds, M522 and M532, have been discovered by isolating them from Salvia miltiorrhiza roots in purities of > 99.5 % as reported by NMR spectral analysis. These two compounds are potent anti-HIV inhibitors and showed no cytotoxicity to human H9 cells at high concentrations. Both M522 and M532 inhibited HIV-1 integrase and acute infection of HIV-1 replication of different strains in drug-resistant and primary isolates with very low doses in human H9 cells. These two drugs are selective integrase inhibitors and hold promise as a novel class of therapeutic drugs for AIDS patients based on their high potencies and absence of cytotoxicity Description (Set) Proposed Use (Set) The discovered drugs are potent and non-toxic integrase inhibitors and they can be used for treatment of AIDS patients in the future.

Patent (Set) 7,071,227

Patents:
US 7,071,227

Inventor(s): Huang, Ru Chih

Type of Offer: Licensing



« More Medical Patents

---