Ty Transposon Plasmids

These clones (pJEF1267/pJEF1262/pD123/pX6/pJEF1114) are useful tools for generating yeast strains with multiple copies of a given gene of interest. These yeast strains contain a pre-virus coding sequence or retrotransposon within the genome, known as Ty1. This sequence functions by inducing hypermutation, an adaptation that has enabled yeast to survive long-term evolutionary pressures. Description (Set) Proposed Use (Set) The manipulation of this hypermutability facilitates the search for drug targets against many viral pathogens, including HIV.

Inventor(s): Boeke, Jef D.

Type of Offer: Licensing



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