Converting Cancer Genes into Killer Genes

A new gene therapy approach has been developed which exploits the genetic alternations characteristic of cancer cells. The method specifically targets cells over-expressing oncogenic proteins, resulting in expression of a gene which leads to death of the tumor cells. The gene therapy constructs can also provide a "bystander" effect to kill cells in close proximity to the tumor cells. In an example of this technology, the inventors have constructed a system that kills cells which overexpress the p53 protein. Description (Set) Proposed Use (Set) A new therapeutic strategy for treating cancer.

Patent (Set) 5,866,340; 6,054,570

Patents:
US 5,866,340

Inventor(s): Vogelstein, Bert

Type of Offer: Licensing



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