Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport. Description (Set) Proposed Use (Set) Provides means to affect cholesterol biosynthesis or transport in a cell
Patent (Set) 6,288,048

Patents:
US 6,288,048

Inventor(s): Beachy, Philip A.

Type of Offer: Licensing



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