Homer Regulates Cellular Calcium Signaling: a Novel Target for Pharmaceutical Development

A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor-activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell-surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer-interacting proteins. Description (Set) Patent (Set) WO 00/11204; 6,720,175; 6,864,083; 772105

Patents:
US 6,864,083

Inventor(s): Worley, Paul F.

Type of Offer: Licensing



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