MoPrP. Xho Vector

This plasmid expression vector was developed to direct the expression of foreign genes in the brains of transgenic mice. The vector, which is transcriptionally dependent on the mouse prion protein promoter, was derived from segments of genomic DNA that compose the mouse prion protein gene, specifically from the promoter, 5' intronic, and 3' untranslated sequences of this protein gene. The vector has been used in multiple settings to produce mice that express human genes in brain, both in neurons and glia throughout the nervous system. Expression in muscle was also noted. This MoPrP.Xho plasmid vector should be very useful in evaluation of over-expression of a variety of wild-type and disease related mutant transgenes in the heart and brain. Description (Set) Proposed Use (Set) Expression vector to produce transgenic mice.

Inventor(s): Borchelt, David

Type of Offer: Licensing



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