R-3327-MAT-Lu

This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this AT-1 sublinein intactmale rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lung (MAT-Lu). This cell line is a valuable model for the studying prostate malignancies both in vitro, and in vivo.DM 3852

Inventor(s): Isaacs, John

Type of Offer: Licensing



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