14-3-3sigma is Required to Prevent Mitotic Catastrophe After DNA Damage

14-3-3Sigma knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Chan et al., 1999 Description (Set) Proposed Use (Set) 14-3-3Sigma promotes pre-mitotic cell cycle arrest following DNA damage. In 14-3-3Sigma knockout cell lines, cells are unable to maintain G2 cell cycle arrest and die as they enter mitosis. The invention provides the basis for a new drug screen to identify compounds that specifically kill cells with checkpoint defects.

Inventor(s): Vogelstein, Bert

Type of Offer: Licensing



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