Carcinogen-specific Induction of Genetic Instability

The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability (CIN) and resistance to 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). The other cell line has microsatelite instability (MIN) and resistance to methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). For details see Bardelli et al., 2001. Description (Set) Proposed Use (Set) This invention provides the basis for a new drug screen to identify compounds that specifically kill aneuploid cancer cells of the CIN or MIN type.

Inventor(s): Vogelstein, Bert

Type of Offer: Licensing



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