Rabbit Serum 5045: Antibodies Against Human BAF`

Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular events such as DNA replication and cell division, participates in chromatin organization, and anchors the nuclear pore complexes embedded in the nuclear envelope. Barrier to autointegration factor (BAF) is an essential conserved double-stranded DNA-binding protein that binds directly to lamin-associated membrane proteins (e.g. LAP2, Emerin, and MAN1), lamin A, homeodomain transcription factors, and human immunodeficiency virus type 1-encoded proteins. BAF influences higher order chromatin structure, is required to assemble nuclei, and facilitates retroviral pre-integration complex insertion into target DNA in vitro. A JHU scientist has generated Serum 5045, a polyclonal rabbit antibody against a recombinant polypeptide comprising His-tagged full length wildtype human Barrier to autointegration factor (BAF). Description (Set) ? Polyclonal antibodies against human BAF Proposed Use (Set) A serum producing polyclonal rabbit antibodies against a recombinant polypeptide comprising His-tagged full length wildtype human Barrier to autointegration factor (BAF) which can be used for immunoprecipitation.

Inventor(s): Wilson, Katherine

Type of Offer: Licensing



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