Rabbit Serum 2999: Antibodies Against Human Emerin

Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins (LAPs). The nuclear lamina provides mechanical support, regulates important cellular events such as DNA replication and cell division, participates in chromatin organization, and anchors the nuclear pore complexes embedded in the nuclear envelope. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family that mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. A JHU scientist has generated Serum 2999, a polyclonal rabbit antibody against a recombinant polypeptide comprising amino acid residues 1-222 of human Emerin. Description (Set) Proposed Use (Set) A serum producing polyclonal rabbit antibodies against residues 1?222 of human Emerin which can be used for immunoprecipitation.

Inventor(s): Wilson, Katherine

Type of Offer: Licensing



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