Methods of Generating Primate Pluripotent Stem Cells from Non-Embryonic Sources

Abstract (Set) Currently, the efficiency of generating human induced pluripotent stem (iPS) cells is low. JHU scientists have found a way to improve it by supplementing an additional gene or bioactive molecules to generate iPS cells from human adult as well as fetal fibroblast. This is the first time when a stringent criterion is met that human iPS cells indeed closely resemble human embryonic stem (ES) cells. The derived cell lines and their blood cell progeny may serve as experimental system to screen new drugs or develop novel therapies. These patient-specific cells could be used for cell-base therapy after the mutated gene is first corrected in the laboratory before transplantation. Description (Set) Proposed Use (Set) New cell lines for screening novel bioactive molecules for reprogramming and treatment of the biological consequences of the underlying mutations

Inventor(s): Cheng, Linzhao

Type of Offer: Licensing

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