Cell Line 2V6.11

Abstract (Set) The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, prevents concatenation of viral genomes in infected cells, inhibits the repair of double strand breaks (DSBs) in the viral genome, and inhibits V(D)J recombination in a plasmid transfection assay. These activities are consistent with a general inhibition by the E4 34k and E1b 55k proteins of DSB repair by non-homologous end joining (NHEJ) on extrachromosomal substrates. To determine whether inhibition of NHEJ extends to repair of DSBs in the cell chromosome, JHU scientists have examined the effects of E4 34k on repair of chromosomal DSBs induced by ionizing radiation in a cell line in which E4 34k expression and biological activity is inducible and E1b 55k is produced constitutively. In addition, JHU scientists demonstrate that in this cell line, induction of E4 34k inhibits chromosomal DSB repair. Description (Set) Proposed Use (Set) Cell line, which inducibly expresses the product of human adenovirus.

Inventor(s): Ketner, Gary W. ,Ketner, Elizabeth

Type of Offer: Licensing

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