Polyamine Analogues with Significant Antitumor and Antiparasitic Activity

Johns Hopkins researchers have synthesized a novel series of terminally alkylated polyamines that have significant biological activity. Some of the analogues have impressive antitumor activity against cultured tumor cells (ling, breast, prostate, and melanoma), while others have excellent activity against parasites such as the African trypanosome, or against the opportunistic organism Microsporidia. Some analogues have been shown to cure infection or to reduce tumor size in mouse studies. Description (Set) Proposed Use (Set) These compounds show promise as potential chemotherapeutic, antimicrobial, and antiparasitic agents.

Inventor(s): Casero, Robert A.

Type of Offer: Licensing

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