Novel Tyrosine Kinases Implicated in Colorectal Cancers
Tyrosine kinases (TK) are the regulators of signaling pathways that control cellular functions such as differentiation, transcription, cell cycle progression, and apoptosis. Tyrosine kinases are sometimes mutated in human cancers although it is not known how many, or how often members of the TK family are altered in a particular cancer type. This invention describes the first systematic mutational analysis of any gene family in colorectal cancer using informatics techniques coupled to amplification and sequencing technologies. Description (Set) Proposed Use (Set) Mutated TK genes are attractive targets for therapeutic intervention in cancer. This technology offers the opportunity to develop individually tailored drug treatment plans based on the specific TK mutation harbored by the patient. Patent (Set) WO 04/082458Inventor(s): Bardelli, Alberto
Type of Offer: Licensing
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