Method of Gene Transfer to the Cardiac Atria

Successful myocardial gene transfer remains an elusive target. Methods used to date include direct injection, pericardial effusion and intravascular administration. Transmural gene transfer has been achieved, but generally with methods that are not readily transferable to the clinic. JHU researchers have discovered that isolated atrial gene transfer could be achieved by direct painting of the adenoviral vector on the atrium. In addition, pluronic gel would increase the time of virus exposure to the tissue, and that mild trypsinization would increase virus penetration. Description (Set) Proposed Use (Set) This invention not only allows transmural gene transfer, but it also isolated the gene transfer to the atria. To treat atrial disease such as atrial fibrillation and sinus node dysfunction (pacemaker). Patent (Set) WO/04/108087

Inventor(s): Donahue, J. Kevin

Type of Offer: Licensing

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