A Library of a Large Collection of Genotypically Defined Mutants

JHU researchers have generated a library of 1,183 genotypically defined Mycobacterium tuberculosis mutants using transposon-mediated random insertion mutagenesis. The transposon used to generate the library, Himar1, has a small but defined target site allowing the disruption of nearly all open reading frames, and a genetic map of the exact mutation sites has been compiled. In addition, custom microarrays have been developed to probe for the presence or absence of each mutant. Description (Set) Proposed Use (Set) This library provides an important tool for drug discovery and for comparative functional genomic studies.

Inventor(s): Bishai, William R.

Type of Offer: Licensing

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