BACE2 Knockout Mice

Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inactivation of both BACE2 alleles Description (Set) Proposed Use (Set) These knock out mice may be used for the assessment of potential mechanism based toxcicity associated with anti-BACE1 therapy in Alzheimer's Disease.

Inventor(s): Wong, Philip

Type of Offer: Licensing



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