A method for high-efficiency clonal isolation and expansion of human embryonic stem cells

JHU researchers have developed a method and identified growth factors for high efficiency cloning, clonal expansion and subculture of human embryonic stem (hES) cells. The invention further describes a method for rapid, high-throughput screening (including genetic screening) for agents (genes, growth factors, chemicals) that regulate all aspects of human embryonic stem cell growth including, but not limited to, cell adhesion, cell survival, cell proliferation, self-renewal and differentiation. Description (Set) Proposed Use (Set) This technology can be used for the derivation of new hES cell lines. In addition, differentiation of hES cells into specialized cells for transplantation therapy, toxicological testing, teratology testing, drug development and testing, and biohazard sensing. Identification of factors required for the growth of hES cells for research and commercial purposes. Improvement of growth conditions for non-human primate (or other mammalian) embryonic stem cell lines. Development of embryonic stem cell lines from species for which such cells do not exist including commercially important species including bovine, porcine and avian. Development of new feeder cell lines expressing neurotrophins could improve hES cell growth and could be commercially useful Patent (Set) WO/2006/072005

Inventor(s): Pyle, April D.

Type of Offer: Licensing



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