Function of GDE Protein Family in Cellular Differentiation

This technology describes a novel retinoid-inducible gene, GDE2 (glycerophosphodiester phosphodiesterase 2) that encodes a 6 TM protein and is necessary to drive spinal motor neuron differentiation in vivo. A single amino acid mutation in the extracellular catalytic domain removes protein function and reveals a critical role for glycerophosphodiester metabolism in motor neuron differentiation. Background During neural development, regulation of cell-cycle and differentiation is essential for cell-fate specification, and proper wiring of neuronal circuits. However, the molecules that direct these events remain poorly defined. In the developing spinal cord, the differentiation of motor neuron progenitors into motor neurons is regulated by retinoid signaling. However, the specific mediator of the differentiation-inducing action remains unknown. Description (Set) Proposed Use (Set) This invention offers potential new treatments for spinal cord injury diseases like Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS).

Inventor(s): Sockanathan, Shanthini

Type of Offer: Licensing



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