Neuropilin-1 Sema Mice

Neuropilin-1 (Npn-1) is a receptor that binds ligands from structurally distinct families like semaphorins (Sema) and vascular endothelial growth factors (VEGF). Npn-1 is a type I transmembrane protein with a small cytoplasmic domain and multiple extracellular domains capable of mediating a variety of protein/protein interactions. Studies using transgenic and knock-out mice of NPN-1 indicate that this molecule is important for vascular and neuronal development. Gene replacement strategy was used to generate a knockout mouse called npn-1Sema-, that expresses a variant of the Npn-1 protein. Interestingly, unlike npn-1 null mice, which die around E12.5, homozygous npn-1Sema- mice survive until birth. Description (Set) Proposed Use (Set) These mice allow investigation of the role of Npn-1 and semaphorins in development

Inventor(s): Ginty, David D.

Type of Offer: Licensing

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