Gowth of Mesenchymal Stem Cells Under Non Adherent Conditions for Clinical Applications

The use of bone marrow derived mesenchymal stem cells (MSC) has been proposed for a number of regenerative therapies including repair of myocardial tissue. The data to date has suggested improved functional outcomes but have failed to demonstrate incorporation of MSC into the tissue. These studies have utilized MSC grown as adherent cells in plastic tissue culture flasks and trypsinized for harvest and infusion. Scientists at JHU have now developed methodologies that allow generation of MSC in non-adherent foci (MSCF) in various support matrices. MSC cultured under these conditions can be passages without trypsinization. When cultured on plastic, the MSCF generate adherent MSC. The continued growth of MSC in the MSCF provides a product capable of seeding damaged tissue in organs where bone surfaces or other solid surfaces are not available for adherence and growth of MSC. Description (Set) Proposed Use (Set) Although the market for stem-cell based therapies is current immature, it is expected to expand dramatically in the coming years. Novel methodologies that aid in the utilization of stem cells for regenerative purposes are of great interest to biotechnology companies now and will continue to be in the foreseeable future.

Inventor(s): McNiece, Ian Keith

Type of Offer: Licensing

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