Mouse Monoclonal Antibody 8A2

Abstract (Set) This technology is a mouse monoclonal antibody, which specifically recognizes vertebra SUMO-2 and SUMO-3. SUMOylation is essential for cell-cycle regulation in invertebrates; however, its functions during the mammalian cell cycle are largely uncharacterized. Mammals express three SUMO paralogs: SUMO-1, SUMO-2, and SUMO-3, the specific localization of which was identified by JHU scientists. Since, SUMO paralogs regulate distinct mitotic processes in mammalian cells, global inhibition of SUMOylation causes a prometaphase arrest due to defects in targeting the microtubule motor protein CENP-E to kinetochores. These findings indicate that SUMOylation is a key regulator of the mammalian cell cycle. Description (Set) Proposed Use (Set) The antibody can be used for immunofluorescence microscopy, immunoblotting and immunopurification.

Inventor(s): Matunis, Michael

Type of Offer: Licensing

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