Salivary Rinse and Serum Detection Test for Head and Neck Cancer

Description (Set) A Johns Hopkins University investigator has identified unique profiles of hypermethylated gene promoters that are effective markers of risk for head and neck cancer. Head and neck squamous cell carcinoma (HNSCC) is a disease that is often diagnosed at an advanced stage. The resulting delay in treatment contributes to increase morbidity. The present invention is an analytical test for early detection of HNSCC based on assessing gene specific promoter hypermethylation in serum and salivary rinse DNA samples and utilizing quantitative methylation-specific PCR (Q-MSP) techniques. Proposed Use (Set) The commercial opportunity is a highly sensitive test to identify individuals at risk for HNSCC, as well as HNSCC patients at risk for relapse or reoccurrence of cancer. Inventor (Set) Califano, Joseph

Inventor(s): Califano, Joseph

Type of Offer: Licensing

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