LRRK2 Fly Model for Parkinson's Disease

Abstract (Set) Mutations in the leucine rich repeat kinase (LRRK2) gene causes late onset autosomal dominant Parkinson's disease (PD). The LRR protein has two enzyme activities (kinase and GTPase) which play important roles in regulating neuronal death and other cellular functions. We have created WT and GS LRRK2 fly models that recapitulate several key features of PD including loss of selective neurons, locomotor dysfunction and early death. Description (Set) Proposed Use (Set) This is the first in vivo "gain-of-function" model to mimic the LRRK2-linked human PD, which provides the useful model for preclinical compound screens for PD intervention. These screens include identifYing the inhibitors of LRRK2 enzme activities and discovering the neural protective compounds to treat PD.

Inventor(s): Smith, Wanli

Type of Offer: Licensing

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