Cardiac Stem Cell and Myocyte Secreted Paracrine Factors

Abstract (Set) Stem cells hold the promise to revolutionize future reparative medicine through the development of stem cell-based therapies. Transplanting stem cells (either embryonic or adult derived) into damaged myocardium is emerging as a novel means for acute repair and as an alternative to organ transplantation or ventricular assist devices in the treatment of end-stage heart failure. The JHU scientists identified unique stem cell-secreted paracrine factors, which can be useful therapeutically and diagnostically in cardiac regenerative treatment by addition or by inducing enhanced cellular expression of one or more of proteins in isolated or cultured stem cells or myocytes prior to, at the time or following administration of therapy or they can be directly administered to the patient for enhancement of endogenous innate cardiac regeneration. Description (Set) Proposed Use (Set) This technology can be used to predict patients that will respond to stem cell therapy and the ability to manipulate the efficacy of stem cell therapy in heart. In addition, this is a method to screen for paracrine factors.

Inventor(s): Van Eyk, Jennifer ,Marban, Eduardo,Stastna, Miroslava

Type of Offer: Licensing

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