RAS KO Lines for Drug Discovery

RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the RAS pathway in human cancer cells or to confirm the specificity of drugs discovered through other approaches. Such drugs can potentially be used as chemotherapeutic or chemo preventive agents for specific cancers.

Inventor(s): Vogelstein, Bert

Type of Offer: Licensing



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