Image Guided Device for Rodent Brains

Stereotaxic device for rodent brains is widely used for various types of brain surgeries, injections, and other types of manipulations. The device is essential for many research labs in Universities and Chemical and Pharaceutical companies. For stereotaxic operations, precision is the key element. Available stereotaxic devices have great precision. However, coordinates of brain regions of interest remain guesswork. This computerized and image-guided stereotaxic device wil greatly improve the accuracy of the stereotaxic procedure and reduce involvement of operators. Description (Set) This invention combines magnetic resonance microimaging and micro CT technologies to create 3D brain atlas of various rat and mouse species at various developmental stages. The map also contains variations of the coordinates among normal individuals. This coordinate information is stored in an electronic format, which will be read by a computer. An operator will identify a region of interest on the electronic atlas. Then the computerized stereotaxic device wil reach the region with great precision. To achieve this goal, there are three important components. First, we need to perform co-registered MRI/CT scans to obtain accurate brain anatomy. This requires high-resolution in vivo MRI and postmortem CT scans. Second, software that bridges the 3D MRI/CT atlas and a stereotaxic device must be written. Namely, this software visualize the 3D electronic brain atlas, accept inputs from operators, and output the coordinates to the stereotaxic device. Third, the stereotaxic device needs to be motorized, which is controlled by the software. Proposed Use (Set) Computer and image-guided stereotaxic device for rodent brains

Inventor(s): Mori, Susumu

Type of Offer: Licensing

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