Estrogen Receptor in Normal (ERIN) Cells

There is no ideal system for studying pre-neoplastic cells that are ERpositive due to the inability to establish an estrogen growth stimulated but non-tumorigenic breast epithelial cell line. Scientists at JHU have developed independently derived clones from the non-cancerous MCF-10A human breast cell line that express ER and are growth stimulated by 17-beta-estradiol (E2) in the absence of epidermal growth factor (EGF), a cytokine normally required for MCF-10A cell proliferation. Description (Set) Proposed Use (Set) The cell lines described above are useful research tools for the study of estrogen and its contribution to neoplastic changes in breast cancer.

Inventor(s): Park, Ben Ho

Type of Offer: Licensing

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