Neuroprotective Actions of Polyphenols, Flavonoid Derivatives and their Respective Extracts

Polyphenols, such as resveratrol, have been linked to many health benefits. This widespread belief stems from its intrinsic antioxidant properties that protect against oxidative damage. Recently, other data has suggested that polyphenols act as signaling molecules to regulate gene expression, the heme oxygenase-1 (HO-1) gene being one example. In addition, increased heme oxygenase activity has led to significant protection against models of in vitro and in vivo oxidative stress injury. Scientists at JHU have now discovered that polyphenols (and all flavonoid-derivatives) and concentrated extracts can induce expression of HO-1 and are effective treatment of acute or chronic neurodegenerative disorders, cerebral ischemia and fight against tissue and brain damage. Description (Set) Proposed Use (Set) It is proposed that these compounds can be employed to fight focal and global ischemia, and also fight against tissue and brain damage. In addition, polyphenols may be used to protect against neurological cognitive deficits following surgeries that effect cerebral blood flow.

Inventor(s): Dore, Sylvain

Type of Offer: Licensing



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