Sequence Motifs that Direct Nuclear Import of Small RNAs

Small RNA species, such as small-interfering RNAs (siRNAs) and microRNAs (miRNAs), have important roles in gene silencing and possess great potential for the development of novel therapeutics. Researchers at Johns Hopkins University have discovered the first known sequence element that regulates the behavior of siRNAs and miRNAs, a motif at their 3' termini that promotes nuclear import. Description (Set) Proposed Use (Set) This invention could be used to develop novel RNA interference-based therapeutics that involve targeting small RNA molecules to the nucleus. These novel nuclear siRNAs could be used to regulate nuclear processes including transcription, mRNA splicing, 3' -end formation, and/or RNA transport.

Inventor(s): Mendell, Joshua

Type of Offer: Licensing

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