Functional Cardiac Tissue Engineering Using Nanostructured Scaffolds for Cardiac Cell Therapy & High-Throughput Drug Screening

This technology incorporates a method to guide the three-dimensional growth and generation of functional cardiac tissues with controlled and enhanced electrophysiological properties using a nanostructured tissue scaffold. Ultraviolet (UV)-assisted capillary lithography or nano-imprinting technique is used to fabricate highly uniform nanopatterned substrates for large scale tissue regeneration on FDA approved biocompatible polymers. Biochemical and/or physical stimuli in the nanostructured scaffolds stimulate the formation of self assembled cell aggregates rich in cell-cell contacts and allow for three-dimensional growth. Background Heart failure is the number one cause of death in industrialized countries. New solutions are needed that are both facile and cost effective to regenerate heart muscle damaged by a myocardial infarction, to overcome the bad prognosis of patients with heart failure, and to address the shortage of heart donors. Description (Set) Proposed Use (Set) This technology enables one to pattern three-dimensional functional cardiac myocytes in order to screen the cellular effects of different drugs or drug candidates in a high-throughput fashion. Additionally, the nanostructured scaffolds allow the user to generate functional cardiac myocytes with controlled and enhanced electrophysiological properties in a high-throughput fashion. This technology is both biocompatible and cost-effective.

Inventor(s): Levchenko, Andre

Type of Offer: Licensing

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