Small molecule as Novel Anti-tumor and Anti-angiogenic Agent

Abstract (Set) JHU scientists found that a known antibiotic that inhibits the type 2 methionine aminopeptidase and possesses anti-angiogenic activity both in vitro and in vivo. It causes both primary human endothelial cells and cancer cells to undergo senescence. It was demonstrated that this antibiotic is capable of inhibiting tumor growth in vivo in animal models and tumor induced angiogenesis in vivo. Description (Set) Dual-action drug for the treatment of different cancer including breast and bladder cancer Proposed Use (Set) This technology can be used to treat a wide variety of diseases that are dependent on angiogenesis and as a dual-action drug for the treatment of different cancer including breast and bladder cancer.

Inventor(s): Liu, Jun ,Bhat, Shridhar,Chong, Curtis,Shim, Joong Sup

Type of Offer: Licensing



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