MicroRNAs As Targets for Anti-Angiogenic Therapies

MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription factor that regulates cell proliferation, growth, and apoptosis. Dysregulated expression or function of c-Myc is one of the most common abnormalities in human malignancy. The MYC cancer gene increases the expression of a cluster of miRNAs that are implicated in the development of human cancers. Scientists at JHU and the University of Pennsylvania have now demonstrated that the MYC-activated miRNAs promote angiogenesis and thus promote tumor growth Description (Set) Proposed Use (Set) These microRNAs represent a novel class of targets for anti-angiogenesis therapies.

Inventor(s): Mendell, Joshua

Type of Offer: Licensing

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