Genomewide Analysis of Chromosomal Translocation

Abstract (Set) The cancer genome is quite unstable with many aberrant genetic translocations dispersed across its sequence. Many chromosomal translocations result in chimeric transcripts resulting in elevated expression levels, believed to be responsible for tumorigenesis. Therefore, it is important to identify these chimeric transcripts, which can be reliable markers for early detection, and provide new targets for drug development. Currently available methods only allow the identification of a handful of chimeric transcripts, and generally require prior information of the putative candidate genes such as their high expressions and other gene functions. JHU scientists have developed a new method to perform Genome-wide Analysis of Chromosomal Translocation (GACT). Description (Set) Key Features: ? First in class method for genome-wide analysis of chromosomal translocation ? Method to identify molecular biomarkers for cancer ? Method to identify therapeutic targets for drug design Proposed Use (Set) Commercially, GACT will provide an unbiased method to find all chimerical transcripts that result in overexpression of the target gene potentially resulting in the identification of specific diagnostic biomarkers and therapeutic targets. This is the first method to perform genome-wide analysis of chromosomal translocation.

Inventor(s): Sukumar, Saraswati V. ,Han, Liangfeng

Type of Offer: Licensing

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