An Approach to Guide the Individualize Development of New Anticancer Agents

The development of new oncology drugs has not resulted in a meaningful improvement in survival of cancer patients. Major reasons are the lack of criteria, models and guidelines to develop individualized treatment plans most likely to produce a successful clinical outcome in a given patient. JHU scientists have developed and optimized a new approach to address this problem. The inventive process involves the generation of live xenograft mouse models using resected tumor tissue obtained during surgery or from fine needle aspirates collected during biopsy procedures. The xenografted tumors can be treated with a battery of anti-cancer agents to determine their in vivo activity and susceptibility to the agent. An individualized treatment plan can then be developed by the treating physician to strive for the best possible clinical outcome. Description (Set) Proposed Use (Set) In addition to its use as a tool for creating individualized treatment plans, this invention may be developed as a screening tool for testing the specific activity of novel anti-cancer drugs. In addition, the xenograft models may be used to explore biological markers of response to treatment agents in tumor tissues.

Inventor(s): Hidalgo, Manuel

Type of Offer: Licensing

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