Generation of Xenografts on Mice to Tailor Anticancer Therapy from Fine Needle Aspiration Biopsies

Xenografts can be made from resected tumors of pancreatic cancer patients in order to generate tumor tissue for the testing of tailored drug regimes. However, the majority of patients with pancreatic cancer (and other types of cancer) are not candidates for tumor resection. Scientists at Johns Hopkins University have developed a method for generating tumors xenografted on nude mice using another technique, fine needle aspiration (FNA) biopsy. FNA biopsy is preferable to the traditional method of tumor resection as more patients are candidates for the procedure; it is minimally invasive and can be performed in an outpatient setting. Description (Set) Proposed Use (Set) The invention describes a platform for the generation of tumors from small starting amounts of biopsy tissue. The invention will allow evaluation of sensitivity or resistance of an individual patient to chemotherapeutic drugs before the patient receives treatment. The most effective therapy can then be administered.

Inventor(s): Jimeno, Antonio

Type of Offer: Licensing

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