A Novel Cystic Fibrosis Therapeutic Agent

Abstract (Set) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- channels (CaCCs) and, thus, is a potential therapeutic drug in the treatment of cystic fibrosis. Cystic fibrosis is the number one genetic killer of children and young adults in the U.S., occurring in about one in 3,000 births. More than 12 million people are carriers of cystic fibrosis. This disease affects the lungs and digestive system of about 30,000 children and adults in the United States and 70,000 worldwide. Description (Set) ?Provides potential therapy in the treatment of cystic fibrosis; ?Stimulates Cl- secretion not only in cystic fibrosis and non- cystic fibrosis human airway epithelial cells, but also in mouse nasal epithelia; ?Shows no toxicity on cells; Proposed Use (Set) Small molecule to treat cystic fibrosis

Inventor(s): Guggino, William B.,Liang, Libua,Schwiebert, Erik

Type of Offer: Licensing

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