Novel Drug Development for Cancer

vivo. Although, the BPU analogs are effective in the palliative management of a wide variety of human malignancies, their utility as chemotherapeutic agents is limited for several reasons: 1) They are almost insoluble in water; 2) they are difficult to formulate; and 3) they have relatively low bioavailability. JHU scientists have addressed these shortcomings by synthesizing and evaluating sulfur and oxygen analogs of these BPU derivatives. The present invention relates to design and synthesis of novel benzoylphenylurea (BPU) sulfur and oxygen analogs with increased potency and enhanced water solubility. Description (Set) Proposed Use (Set) These compounds may useful for the treatment of human malignancy.

Inventor(s): Khan, Saeed R.

Type of Offer: Licensing

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