Regional Chemotherapy with 4-Hydroperoxycyclophosphamide (Intrathecal Administration)

A method of treating human tumors is provided in which tumors are regionally treated with a cytolytic, pre-activated, bifunctional alkylating agent, namely 4-hydroperoxycyclophosphamide. The treatment is effective against a variety of tumor types within the central nervous systems. Cyclophosphamide, an alkylating agent with a broad spectrum of anti-tumor activity is actually a prodrug which, to be activated must be converted by hepatic microsomal enzymes into 4-hydrocyclophosphamide. This compound subsequently undergoes spontaneous decomposition to a variety of biologically active compounds. Because of its requirement for hepatic activation, cyclophosphamide cannot be used for regional therapy. Description (Set) Proposed Use (Set) The treatment is effective against a variety of tumor types within the central nervous systems Patent (Set) 0465512; 642868; 2,049,341; 5,407,925

Inventor(s): Colvin, O.M.

Type of Offer: Licensing



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