Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Description (Set) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ischemia (stroke) similarly; blood vessel breakage in the brain is cerebral hemorrhage (stroke). These blood vessel miscues result in the initiation of an ischemic cascade that includes an inflammatory response and ultimately cell death in the brain. Cyclooxygenase (COX)-2 inhibitors are well known for their use as anti-inflammatory agents and have also been shown to reduce the damage associated with neuroinflammatory disorders. COX-2 inhibitors inhibit the production of prostaglandins, many of which mediate the inflammatory response. Unfortunately, COX-2 has been associated with increased risk of cardiovascular disease and stroke. As a result of these risks, there is a need for therapeutics that act in like manner to COX-2 inhibitors without the related side effects. Based on this information, scientists at Johns Hopkins University have found that blocking a specific prostaglandin receptor either before or after an ischemic or hypoxic event will reduce neurological-associated injury. Proposed Use (Set) The American Heart Association estimates that each year approximately 700,000 people suffer a new or recurrent stroke in the United States. Over 150,000 of these people die, making stroke the third leading cause of death. The work of JHU scientists involves potential prophylactic or therapeutic agents that can act against neurological disregulation in situations where blood flow and/or neuronal homeostasis is impaired in either acute or chronic neurological conditions.

Inventor(s): Dore, Sylvain

Type of Offer: Licensing

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