Methods for Treatment of Rheumatoid Arthritis

Description: Rheumatoid arthritis affects approximately 1% of the world’s population, and is a significant cause of morbidity. Current therapies for rheumatoid arthritis are based on suppressing the immune system, either by interference with the function of lymphocytes or cytokines. However, until a cure for rheumatoid arthritis is found, other molecules and pathways need to be considered as potential therapeutic targets. The invention is based on the discovery that a peptide neurotransmitter plays a role in the effector phase of arthitogenesis. This neuropeptide has previously been implicated as having a role in the regulation of inflammation, and the inventors have discovered that mice deficient in the neuropeptide do not develop arthritis in a well-studied model where the disease can be induced experimentally (the K/BxN system). Clinical & Commercial Utility: The invention comprises methods of treating or preventing the development of rheumatoid arthritis by inhibiting this neuropeptide. Among preferred methods of inhibition are the use of inhibitory nucleic acids such as siRNA, inhibitory peptides, or an antibody or antigen binding fragment directed at the neuropeptide. This neuropeptide is a promising new target for investigation of new avenues of therapy for rheumatoid arthritis.
A worldwide PCT application claiming this invention has been filed.

Type of Offer: Licensing

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