Insulin Receptor Substrate Knockout Mice
Description: The IRS proteins are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways triggered by insulin’s binding to its receptor. Insulin Receptor Substrate-1 (IRS-1) is a substrate for tyrosine phosphorylation by the activated insulin receptor B subunit following receptor activation. The IRS-2 protein is part of a family of proteins which are substrates for the insulin receptor, as well as the IL-4 and IL-15 receptors. Clinical & Commercial Utility: The available technology features knockout mice lacking either the IRS-1 or IRS-2 gene. IRS-1 knockout mice show 50% reduction in intrauterine growth, impaired glucose tolerance, and resistance to the glucose-lowering effects of insulin. IRS-2 knockout mice show a phenotype that is like Type 2 diabetes, and have also been shown to exhibit female infertility. These mouse models are useful in drug screening for diabetes and other insulin-related disorders. Joslin Diabetes Center is the owner of U.S. Patent Numbers: 5,260,200 5,621,075 5,858,701Type of Offer: Licensing
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