Method of Visualizing Chromosomes of Somatic Cells that Do Not Divide

Description Examination of mitotic chromosomes is essential for cytogenetic research, in particular for the chromosomal mapping of the genes responsible for some genetic disorders and cancers linked with the chromosomal alterations. Till today, no methods have been developed to visualize mitotic chromosomes of postmitotic cells (e.g., neurons). Chromosomes become visible only during cell division. Adult brain cells never divide and therefore their chromosomes have never been examined. This is a method that allows visualization of the chromosomes of these non-dividing adult neurons and perhaps those of all other non-dividing cells.

Applications Basic biological studies of various disciplines, analysis and diagnosis of cell/tissue pathology, and search for the causes of various diseases. Tools in cytogenetics, detection of postmitotic cells, aneuploidy, chromosome translocation, inversion, deletion, etc.

Main Advantages This breakthrough method provides a way to examine complete sets of chromosomes of non-dividing cells, which was not previously possible. Many serious diseases such as dementia and heart attack may be from mutations in postmitotic neurons or heart myocytes. It may be possible to see the mutations or chromosomal aberrations by this method. This method would become even more powerful if combined with the latest molecular cytogenetic approaches.

Type of Offer: Licensing

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