A Rapid Method for in vivo Synthesis of Large Libraries of Cyclic Peptides
Dr. Eric Schmidt and colleagues at the University of Utah have found a novel method to synthesize large libraries of amide-linked, modified cyclic peptides by expression of constructs in Escherichia coli.
*Currently, technology to synthesize amide-linked cyclic peptide libraries is limited.
*Modified peptide libraries have not yet been synthesized in large scale.
*Cyclic peptides in general have advantages over their linear relatives in that they sample a more constricted conformational and configurational space.
*This technology can be potentially used in: (1) drug discovery; (2) drug design; (3) drug development; (4) peptide synthesis and modification; (5) biochemistry and (6) environmental purposes.
Stage of Development
A PCT patent application has been filed with the U.S. Patent and Trademark Office and is pending. This technology is part of an active and ongoing research program, which has been demonstrated to work in proof-of-concept experiments and includes a working prototype. It is available for developmental research support/licensing under either exclusive or non-exclusive terms.
*Schmidt, Eric W., et al (2005) Patellamide A and C biosynthesis by a mircocin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella, PNAS, 102: 7315-7320.
Brian Hathaway, Eric Schmidt, James Nelson, Mohamed Donia
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