Steroid Profiling in Ovarian Follicular Fluid, Importance for Diagnosis, Prognosis, and Determining Strategies for Treatment

Very sensitive assays for assaying concentration and profile of steroid biomarkers in small volumes of ovarian follicular fluid have allowed identification of specific steroid profiles which are useful for diagnosis of specific endocrine disorders, and assessing ovarian function. Steroid profiles can allow definitive diagnosis of a variety of endocrine disorders affecting ovarian function and fertility, and will be useful for determining which modes of treatment might be effective.

For example, the inventors have identified a specific steroid profiles which is diagnostic for Polycystic Ovary Syndrome (PCOS), and methods for detecting this profile in follicular fluid. Since symptoms for PCOS overlap with other endocrine disorders and no established biomarkers for PCOS exist, definitive diagnosis of this condition has been difficult.

Steroid profiling of follicular fluid should enable the definitive diagnosis of a variety of endocrine disorders, including PCOS. It may also lead to improved methods for ovarian hyperstimulation during IVF treatment and assays which can to predict likelihood of IVF success. The assay and methods may also be useful as a tool for developing and assessing efficacy of novel therapies to restore ovarian function and fertility.

Stage of Development
A provisional patent application for this invention has been filed with the U.S. Patent and Trademark Office. This technology is part of an active and ongoing research program and in the subject of ongoing clinical studies.

Additional Info
� Kushnir et al. (2008) Am J Clin Pathol.129:530-9
� Kushnir et al. (2006) Clin Chem. 52:120-8
� M Kushnir doctoral thesis
� M Kushnir web page

Inventor(s): Tord Naessen, Mark Kushnir, Jonas Bergquist

Type of Offer: Licensing

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