Liquid Composition of Cisplatin Coordination Compounds
Disclosed is a liquid composition. The liquid composition is characterized by comprising a polymer micelle, wherein the polymer micelle comprises a coordinate compound comprising a block copolymer of polyethylene glycol and polyglutamaic acid and cisplatin attached to the block copolymer through a coordinate bond. The liquid composition is also characterized by having a pH value of 3.0 to 7Ö.
Although cisplatin (cis-diamine-dichloroplatinum (II)) is an extremely useful anticancer drug used in the clinical setting, it is known to have extremely potent adverse effects such as nephrotoxicity. Consequently, large-volume liquid infusion is required before, during and after administering cisplatin.
In order to resolve this problem, a coordination compound has been invented in which cisplatin is coordinate-bonded to a block copolymer consisting of polyethylene glycol and polyglutamic acid.
KATAOKA KAZUNORI [JP]; NISHIYAMA NOBUHIRO [JP]; TSUCHIYA CHIEKO [JP]; HAYASHI TATSUYUKI [JP]
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