Transgenic rodent expressing truncated disc 1
The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia- related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncatedDisc1genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc 1 polypeptide truncated before exon 9; (2) 2 copies of endogenousDisc1genomic DNA sequence encoding full length Disc 1 polypeptide. Also provided are related materials and methods.
SHEN SANBING [GB]; RIEDEL GERNOT [GB]; CLAIR DAVID ST [GB]
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