Biomedical Patents for Sale or License

Osteotome System

A plurality of osteotomes that are linked together via a recess and a matching projection such that the osteotomes remain linked when used to manipulate bone.
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Therapeutic Nucleic Acid-3'–Conjugates

Methods are described for improvement of the serum half life of therapeutic nucleic acids by 3' conjugation to useful target proteins, or other large molecules with useful function. In one embodiment, a 3' A, C or G overhang is added to ds-DNA and the primary amines conjugated using biocompatible bifunctional linkers to proteins. The resulting nucleic acid-3'-conjugates are serum nuclease-resistant and retained in vivo for long periods without rapid kidney clearance. Further, the choice of conju
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Methods of Producing Intrachain Fluorophore-Quencher FRET-Aptamers and Assays

The present invention describes methods for the production and use of single chain (single-stranded) fluorescence resonance energy transfer ("FRET") DNA or RNA aptamers containing fluorophores (F) and quenchers (Q) at various loci within their structures, such that when its specific matching analyte is bound and the FRET-aptamers are excited by specific wavelengths of light, the fluorescence intensity of the system is modulated (increased or decreased) in proportion to the amount of analyte adde
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Methods and compositions of DNA ligands (aptamers) for arthropod-borne pathogen detection and prophylaxis or therapy

Specific DNA ligand sequences (aptamers) for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two- and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linakge of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity a
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Methods and compositions of nucleic acid ligands (aptamers) for detection of clinical analytes related to human health

Specific DNA sequences (aptamers) for binding various clinically relevant analytes from the human body are described. Each of these sequences or their linear, two- and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linakge of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances
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Fingertip Force, Location, and Orientation Sensor

An integrated system for studying human grasping techniques includes a fingerprint sensor and a force sensor for simultaneously measuring the contact position and orientation of a fingertip together with the contact force and torque exerted by the fingertip during a grasp. The system uses the fingerprint image obtained from the fingerprint sensor to identify the contact position and orientation of the fingertip based on fingerprint features such as the core point and local ridge orientations. Th
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Volume Exclusion Agent to Enhance Formation of Extracellular Matrix

A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition involves procollagen processing to collagen, fibril assembly and deposition into the cell layer to form a collagenous extracellular matrix. The addition of certain growth factors and the addition of a thin layer of a certain volume
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Salmonella-based anti-cancer vaccine

We offer a technology of vaccine-based cancer therapy developed at the Jagiellonian University (Krakow, Poland). The immunotherapy is based on genetically modified bacterial strain of Salmonella VNP20009 that is able to target and preferentially colonise tumour tissue. Tumour targeting of VNP20009 was enhanced by single chain antibody fragments specific to carcinoembryonic antigen, which are expressed on the surface of the bacteria. Further genetic modifications were introduced to the strain to
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Robotic Surgical Device

A robotic surgical device for use in laparoscopic surgery, includes two robotic arms in parallel relationship with each other. Each arm has 7 DOF providing a total of fourteen degrees of movement, accuretaly reproduce the movements of a human torso complete with arms. The device allows a direct correlation between surgeon’s articulations and RSD joints. Easier for the surgeon to control, since it can be maneuvered using the same movements learned during the standard training, lowering surg
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Real Time Dose Verification in Radiotherapy

A team from the Universities of Bristol and Swansea together with University Hospitals Bristol NHS Foundation Trust has developed a novel radiation detector device for determining the dose from Intensity Modulated Radiotherapy (IMRT) in real time. The detector is positioned upstream of the patient (between radiation source and patient) and is a very thin silicon detector camera system.
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Anti-jaundice composition for corpses and method

The anti-jaundice patent is proven to reverse discoloration caused by jaundice. An added benefit demonstrates the formulation reversing discoloration arising from high medication and post cancer remains. I have additional patentable products available in the same lucrative market.
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Biostimul Pharma

BIODEX:500mg Patent claim BIODEX: calcium clusters (calcium peptide complexes) with modified calcium clusters (calcium peptide complexes)- with enhanced biochemical and biological features, that are extracted by non-chemical, patented process is handled by microscopic particles and they are absorbed by the body fast. As a result, is obtained and a mixture of calcium clusters (calcium peptide complexes), including a group of 27microelements: mainly copper, iron, manganese, molybdenum, phosp
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Methodology and Apparatus for the Detection of Biological Substances

Patent has very broad claims which cover various designs and features for biosensors and/or chemical sensors including bio-FET devices. In particular, it covers wireless and non-wireless communications of sensors with a central server or sensors within networks, for example within a distributed real-time monitoring program. These claims may be valuable for biosensors used in medical and biomedical diagnostics including bacterial or viral infections, disease biomarkers etc., bioweapon detec
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Method and System for Fusing a Spinal Region

A method and system for fusing a region in the spine involve the use of at least one guide tube (10a) to pass instruments and substances into the spinal region in a minimally invasive manner. In the preferred practice of the method, a guide tube is anchored to a vertebra and the guide tube is moved to thereby position the vertebra. A steerable drilling tool (20a) is passed through the guide tube and steered into position to abrade at least a portion of an intervertebral disc, thereby creating a
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Systems, Devices, and Methods for Interpreting Movement

According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable.
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Ultrasound-based Method and Related System to Evaluate Hemostatic Function of Whole Blood

Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mech
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Methods and Compositions for Molecular Imaging

Methods for imaging a target cell, tissue, or organ in a subject. In some embodiments, the methods include the steps of (a) administering to the subject a contrast agent that includes a paramagnetic or superparagmanetic material and a targeting moiety that targets the contrast agent to the cell, tissue, or organ; (b) introducing into the target cell, tissue, or organ, or into the vicinity thereof, a hyperpolarized gas; and (c) imaging the target cell, tissue, or organ by detecting the presence o
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Magnetic Resonance Imaging And/or Spectroscopy Contrast Agents and Methods of Use Thereof

The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be recovered into an observable transition. Coupled with hyperpolarization techniques, this permits the preparation of a wide range of contrast agent molecules for use in magnetic resonance imaging (MRI) techniques that have long effective relaxation time.
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Single-cell Biosensor for Measuring GPCR Ligand in Test Sample

PROBLEM TO BE SOLVED: To provide a method for measuring the presence and concentration of a GCPR ligand in a test sample including a biological or environmental sample. ; SOLUTION: Provided is the method for the detection of the GPCR ligand in the test sample by using a single cell biosensor expressing the GPCR. Preferably, the test sample is derived from a biological or environmental sample. The method may be used to detect the presence of a disease or to detect the presence of a harmful agent
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Radiolabled Cyclopamine Assay for the Smoothened Receptor

The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.
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Methods for single-pass volumetric bidirectional blood flow imaging Spectral Domain Optical Coherence Tomography using a modified hilbert transform

The present subject matter relates to in vivo volumetric bidirectional blood flow imaging using single-pass flow imaging spectral domain optical coherence tomography. This technique uses a modified Hilbert transform algorithm to separate moving and non-moving scatterers within a depth. The resulting reconstructed image maps the components of moving scatterers flowing into and out of the imaging axis onto opposite image halfplanes, enabling volumetric bidirectional flow mapping without manual seg
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Combination for an Adhesive Bonding of Biological Tissues

The present invention relates to a combination, especially for bonding and / or fixation of biological tissues, the combination of components a) a polysaccharide stickstofffunktionalisiertes and b) a terminally functionalized Oligolacton covers.
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Device for ventilating the middle ear, has stent having hollow cylinder which has funnel-shaped expansion at two ends, where inner diameter of hollow cylinder lies in certain range

The device has a stent (10) having a hollow cylinder (12) which has a funnel-shaped expansion (18) at two ends (14,16). The inner diameter of the hollow cylinder lies in the range of 0.5 millimeter to 10 millimeter. The stent has a length in the range of 1 centimeter to 5 centimeter along the longitudinal axis. The stent consists of a biocompatible elastomer. A cladding (20) of the hollow cylinder has a notch in the area of the funnel-shaped expansion. The biocompatible elastomer is silicon or p
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Method for producing cellulose acetals

Acetalizing poly-, oligo-, di- saccharide or its derivative comprises dissolving the poly-, oligo or di saccharide in an ionic liquid and reacting the obtained mixture with a vinyl ether. Independent claims are included for: (1) acetylated cellulose obtained by the above method; (2) preparation of cross linked cellulose comprising dissolving the poly- or oligo- saccharide or its derivative, in at least an ionic liquid and reacting the obtained mixture with the vinyl ether and an acid; and (3) th
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Optical Assay System for Intraoperative Assessment of Tumor Margins

The subject matter described herein includes an optical assay system for intraoperative assessment of tumor margins. According to one aspect, the subject matter described herein includes a biological sample containment and illumination apparatus for holding a biological sample for illumination by a plurality of electromagnetic radiation probes. The biological sample containment and illumination apparatus includes a plurality of frame members positioned with respect to each other to form an inter
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Compositions and Methods for Identifying Ligands of Odorant Receptors

The present invention relates to compositions and methods for identifying odorant-odorant receptor interactions. In particular, the present invention relates to in silico methods for identifying odorant receptor-odorant interactions based on chemical and physical properties of odorant receptors and odorants.
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Non-regular Electrical Stimulation Patterns for Treating Neurological Disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
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Assessing Pulmonary Gas Transfer in Lungs Using Hyperpolarized 129Xe MRI

A method for providing MRI data of pulmonary gas exchange and/or alveolarcapillary barrier status is disclosed. The method comprises transmitting an RF MRI excitation pulse imaging sequence configured to excite dissolved phase hyperpolarized 129Xe in a gas exchange region of a lung of a subject; and generating a three-dimensional 129Xe MRI image of a gas exchange region of the lung using dissolved phase 129Xe MRI image signal replenishment data associated with both red blood cell (RBC ) compartm
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Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering

A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, wherein the optical probe includes at least one entity for emitting light that interacts with a tissue mass and then is remitted to a collecting entity, for collecting the light that has interacted wit
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Elastin-like polypeptide and gadolinium conjugate for magnetic resonance imaging

A magnetic resonance imaging (MRI) contrast enhancement agent comprising an elastin-like polypeptide (ELP) and one or more paramagnetic metal ions is disclosed. Also disclosed are methods of preparing ELP MRI contrast enhancement agents, formulations comprising ELP MRI contrast enhancement agents, and methods of using ELP MRI contrast enhancement agents to image biological samples and to image and deliver therapeutic agents to targeted sites in vivo. In some embodiments, the ELP MRI agents can b
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Method for the Modulation of Function of Transcription Factors

There is provided a method of modulating the function of transcription factor by administering an effective amount of an oligonucleotide containing optimal nucleotide binding sites for the transcription factor. A therapeutic agent having an effective amount of an oligonucleotide for modulating function of transcription factors and a pharmaceutically acceptable carrier is also provided. Also provided is a treatment of patients having illnesses in which the activation of transcription factors play
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Cartesian Human Morpho-informatic System

The present invention is a three dimensional Cartesian coordinate system for the human body, having three perpendicular and intersecting planes. The present invention is based upon the use of the three cardinal planes, in the universally recognized orientations. The cardinal planes in accordance with the present invention are: Sagittal: midsagittal plane, Transverse: upper-most extent of the iliac crests, and Coronal: anterior-most aspect of the vertebral canal. The point at which these planes i
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Electrogenic pump molecule control

Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. We studied synchronization of the Na/K pump molecules in a physiological running mode by applying the concept of an electronic synchrotron to the biological system. Both theoretical analysis and experimental results showed that individual Na/K p
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Device and Method to Facilitate Directed Delivery and Electroporation Using a Charged Stream

A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated by a direct current voltage applied to an electrode, to the molecule and biological structure. The field is applied for a duration sufficient to effect a change in porosity the cell of the biological s
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Asymmetric Disc Distracting Cage

An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate during the distraction process when the interbody cage is impacted.
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Computer System and Computer-Implemented Method for Providing Personalized Health Information for Multiple Patients and Caregivers

Personalized health information is provided by maintaining a patient profile over time and matching information from the patient profile to appropriate patient-centric information related to that patient's specific medical condition. The patient profile can include a variety of medical information. The patient profile is matched, for example, to patient-centric options for care, clinical trials for which the patient is eligible, drug treatment regimens directly related to each patient's specific
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Vertebral Body Cage

A intervertebral body device for supporting adjacent vertebrae includes a vertebral body member having at least one containment portion and one communicating portion. The containment portion and communication portion provide two distinct functional regions within the cage. One region of the cage provides for the use of a biologic material, and the region of the cage provides holes in the side or the front of the cage in order to allow bony ingrowth into that portion of the cage. Where numerous s
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Method for Early Detection of Cancers

The invention includes methods for detecting the presence of a neoplastic condition by comparing a sample level of a BIF-1 to a reference, wherein a low level of BIF-1 in the sample correlates with the presence of a neoplastic condition. Another method involves determining the risk of relapse, tumor recurrence and/or metastasis by determining a sample level of a Bif-1 to a reference level of Bif-1, wherein low sample levels correlate with a likelihood of relapse, recurrence and/or metastasis. Ye
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Method of Detecting Oncogenesis of Hematopoietic Cells

Disclosed in a method of detecting cancer using IL-27 receptors. IL27R is a cytokine receptor identified as a novel oncogene from an acute myeloid leukemia patient. It induces cancer-like properties when expressed in cells and can activate a protein that causes various myeloid cell disorders. The data show cytokine receptors play unappreciated roles in mediating activation of signaling pathways in circulatory system cancers. Also method of screening for novel oncogenes using a functional, approa
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CT Atlas of Musculoskeletal Anatomy to Guide Treatment of Sarcoma

The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of musculoskeletal structure. The atlas contains a data set representing a 3D model of musculoskeletal structure divided into the relevant musculoskeletal anatomic terminology. The method further includes obtaining patient data. The patient data is in a patient coordinate set that corresponds to obtained atlas data in the atlas coordinate set. The atlas data is then morphed using a fir
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Method of Electrogenically Controlling Pump Molecules

Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example in a physiological operating mode by applying the concept of an electronic synchrotron to the biological system. It was shown that individual Na/K pump molecules can be synchronized by a well designed
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Multichannel Trocar

A multi-channel trocar developed for use in 'minimal-access surgery/single incision laparoscopic surgery. The trocar permits surgical access of two or more articulating laparoscopic instruments or scopes through one skin incision using a dividing membrane to separate the working channels. This allows maximal use of robotic technology and permits more degrees of freedom at the operative site. The trocar is inserted through one single skin incision, in the usual manner. The trocar relocates the fu
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Control of Harmful Algal Blooms By Induction of Programmed Cell Death

The subject invention pertains to compositions, apparatus, and methods for controlling harmful algae and harmful algal bloom (HAB) based on the induction of the programmed cell death (PCD; apoptosis) pathway in the harmful algae, and to kits for determining algal susceptibility to PCD induction.
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Cubic Silicon Carbide Implantable Neural Prosthetic

An implantable neuronal prosthetic and method of manufacture thereof includes at least one elongated electrode shank adapted for arrangement in the brain having at least one electrode contact disposed on its surface and arranged to electrically couple with said brain. The at least one elongated electrode shank is formed form a single crystal cubic silicon carbide. An insulation layer of amorphous, polycrystalline, or single crystal silicon carbide is disposed over the elongated electrode shank;
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Method and Apparatus for Pulmonary Ventilation Imaging Using Local Volume Changes

The invention provides a novel method of high-resolution quantifiable pulmonary regional ventilation imaging using a package of computer programs, including deformable image registration and local volume change calculation on 4-D or breath-hold CT images. High resolution 3D ventilation images have been generated using this technique with superior quality. The deformation matrices between different respiration phases are calculated using deformable image registration and applied to calculate loca
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Autonomous genosensor apparatus and methods for use

An autonomous genosensor apparatus and methods for use are provided for the field detection and analysis of ambient chemical, biochemical, biologic, biogenetic, and radiologic materials under field conditions in fluid or gaseous environments, such as marine or aquatic environments or industrial processes. Autonomous genosensors provide integral, self contained units which automatically extract environmental samples, prepare those samples for analytical studies, analyze those samples using studie
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Biological Active Proteins Having Increased in Vivo And/or Vitro Stability

The present invention relates to biologically active proteins comprising at least two domains wherein a first domain of said at least two domains comprises an amino acid sequence having and/or mediating said biological activity and a second domain of said at least two domains comprises an amino acid sequence consisting preferably of at least about 100 amino acid residues forming a random coil conformation whereby said random coil conformation mediates an increased in vivo and/or in vitro stabili
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Probes and Methods for Detecting Analytes

Embodiments disclosed herein relate generally to probes, methods, and kits for detecting the presence of a target analyte. The probe generally comprises two strands that have regions of complementarity and do not associate with each other at the reaction temperature. In the presence of an analyte, the two strands of the probe can hybridize to each other, and the analyte can hybridize to both strands of the probe in a juxtapose manner to form a tripartite structure (probe-analyte complex). If the
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Methods and Systems for Using Therapeutic, Diagnostic or Prophylactic Magnetic Agents

Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and live
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Biosensors

Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of the substrate and wherein the ligand preferentially binds to a receptor.
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Novel Compositions and Methods for Stimulating Erythropoiesis in a Mammal

The present invention relates to compositions comprising an agent which activates herpes virus entry mediator (HVEM). The present invention also relates to compositions comprising an agonist of HVEM. The present invention also relates to methods of stimulating erythropoiesis in a mammal, comprising administering to a mammal a composition comprising an agent which activates HVEM, or is an agonist of HVEM. The present invention also relates to methods for treating an anemic disorder, comprising ad
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Determination of Site of Origin for a Natural Electrical Pulse in a Living Body

Techniques include determining a first vector of temporal changes in electrical data measured at multiple electrical sensors positioned at corresponding locations on a surface of a living body due to a natural electrical pulse. A different vector of temporal changes in electrical data measured at the same electrical sensors is determined due to each stimulated signal of multiple stimulated signals within the living body. Stimulated position data is received, which indicates a different correspon
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Methods and Devices for the Detection of Biofilm

The present invention provides methods and kits for biofilm detection.
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Blood Coagulation Inducing Polymer Hydrogel

The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood
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Conjugates of 19F MR Imaging Tracers for Use in Multi-chromic MRI Imaging

Compositions for producing multi-chromic ("color") magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19F imaging tracer (19FIT), conjugated with a magnetic signal modulator, such as a paramagnetic functional group or a paramagnetic ion. The 19FIT and the signal modulator (M) are joined covalently by a chelator such as DOTA, forming a nanometer-sized fluorinated paramagnetic complex 19FIT-
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Metal-enhanced Fluorescence for Polarization-based Affinity Assays

A method and kit for determining the quantity of an analyte include providing a functionalized substrate and a reagent. The functionalized substrate includes metallic nanoparticles and a plurality of substantively identical bioactive target molecules affixed to a substrate. The bioactive target molecule binds to a particular analyte. The reagent includes identical detection molecules. Each detection molecule includes a fluorophore, and binds to a particular analyte or competes with a particular
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Arc-Sequencing Technique for Intensity Modulated Arc Therapy

The invention is directed to a radiation therapy method, and in particular, to a method of conducting an intensity modulated arc therapy (IMAT). The invention provides a planning technique that translates traditional static fixed-field IMRT plans into deliverable IMAT plans and allows IMAT to be realized as a routine clinical delivery technique.
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Apparatus and Method for Automating an Enema with Controlled Distension

An apparatus and method are provided for use in administering a rectal contrast enema to a patient to prepare the patient for a medical procedure. A rectal catheter may be provided to facilitate administration of the enema preparation to the patient. The rectal catheter may include a retention balloon. A delivery mechanism may be provided to urge the enema preparation into the patient. A vacuum may be provided to remove waste from the patient. A gas insufflator may be provided to insufflate the
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Proximal Radius Locking Plate

The invention provides a proximal radius locking plate having a body comprising an elongate shaft portion and a head portion. The plate may have a gentle S-shape and a proximal twist. The shaft portion is adapted for receiving bone screws to fix the bone plate to a shaft of the radius. The head portion includes a first head section and a second head section. The first and second head sections extend laterally away from a longitudinal axis of the shaft portion in generally opposite directions, ge
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Fracture-specific Distal Radius Plates

The invention provides an improved distal radius locking plate having a body comprising a shaft portion and a head portion. The shaft portion is adapted for receiving bone screws to fix the bone plate to a shaft of the radius. The head portion includes a first head section and a second head section. The first and second head sections extend laterally away from a longitudinal axis of the shaft portion in generally opposite directions, generally forming a T-shape. The first and second head section
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Electrosurgical Element and Uterine Mainpulator for Total Laparoscopic Hysterectomy

A vaginal cervical retractor used to maneuver and visualize the uterus during various medical examinations and procedures would include an inner tube provided with a movable assembly of plastic cups (cervical cup and vaginal cup) designed to be inserted into the uterine cavity and a retractable electrosurgical needle. A cervical cup is molded to a hollow outer shaft to form the movable cup assembly. This hollow shaft is provided through which the inner tube can be inserted. By utilizing a vagina
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System and Method for Providing Optimal Concentrations for Medication Infusions

Techniques for medical infusions include determining a first infusion rate for administering a first medication to a patient. A fluid load is determined based at least in part on the first infusion rate. It is determined whether the fluid load exceeds a predetermined threshold based on a fluid maintenance rate. If it is determined that the fluid load exceeds the predetermined threshold, then an action is caused to inhibit administering the first medication to the patient at the first infusion ra
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Composite Images for Medical Procedures

Medical imaging often involves the collective use of information presented in multiple images of an individual, such as images generated through different imaging modalities (X-ray, CT, PET, etc.) The use of a composite of these images may involve image registration to adjust for the variable position and orientation discrepancies of the individual during imaging. However, registration may be complicated by soft tissue deformation between images, and implementations (particularly pure software i
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Devices, Systems and Methods for Magnetic-assisted Therapeutic Agent Delivery

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.
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Contrast Agents

The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
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Compositions and Methods Comprising Magnetic Resonance Contrast Agents

The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
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Mri Contrast Agents and Related Methods of Use

The present invention relates to contrast agents for MRI and related methods of use.
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Barriers for Facilitating Biological Reactions

The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.
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Catheters and Electrophysiological Devices

The present invention provides systems and methods of use for catheters and electrophysiological devices. In particular, the present invention provides coronary catheters within which an extendable electrode array is housed.
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System and Method for Leveraging Human Physiological Traits to Control Microprocessor Frequency

A system and method for leveraging physiological traits to control microprocessor frequency are disclosed. In some embodiments, the system and method may optimize, for example, a particular processor-based architecture based on, for example, end user satisfaction. In some embodiments, the system and method may determine, for example, whether their users are satisfied to provide higher efficiency, improved reliability, reduced power consumption, increased security, and a better user experience. T
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Biodegradable Nitric Oxide Generating Polymers and Related Biomedical Devices

Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing N2O2- (NONOate) functional group. The polymer can be applied to various medical devices for the treatment of various diseases such as thrombosis and restenosis.
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Compositions and Methods for Imaging Cells

A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.
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Mri Involving Replacement of an Antenna By Another Antenna

A system that incorporates teachings of the present disclosure may include, for example, a Magnetic Resonance Imaging system comprising a Magnetic Resonance (MR) scanner to selectively couple to one among a plurality of antennas without compromising spatial alignment with an anatomical sample during signal acquisition by the MR scanner. According to one embodiment, the invention teaches to replace a single-tuned antenna tuned to a first resonance frequency by another single-tuned antenna tuned t
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System and Method for Ultrasonic Image Processing

A system that incorporates teachings of the present disclosure may include, for example, an ultrasonic (US) imaging system having a transducer, and a controller managing operations of the transducer. The controller can be operative to cause the transducer to transmit a coded ultrasound signal to an object, cause the transducer to receive an altered coded ultrasound signal from the object, decode the altered coded ultrasound signal to attain a desired bandwidth that exceeds an impulse response of
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Imaging of Anatomical Structures

A system that incorporates teachings of the present disclosure may include, for example, an imaging device having a Magnetic Resonance Image (MRI) scanner to generate MRI data associated with soft tissue of a patient, and supply said MRI data to diagnostic equipment that selects one or more normative soft tissue profiles of a select anatomical section, and generates a three dimensional soft tissue image from the MRI data and the one or more normative soft tissue profiles. Additional embodiments
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System and Method for Prosthetic Fitting and Balancing in Joints

A system and method for prosthesis fitting in joints comprising an artificial condyle and a spacer which cooperates with the condyle to form an artificial joint. The spacer embedded with at least one sensor which is responsive to a force generated between the condyle and the spacer. The artificial joint is adapted to move between a flexed position and an extended position defining a range of motion. The sensor is responsive to the force and generates an output representative of that force. The o
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Fret-based Membrane-type 1 Matrix Metalloproteinase Biosensor and Methods for Using the Same

The present invention is a novel FRET-based biosensor composed of ECFP and YPet fluorescent proteins operably linked via a MT1-MMP recognition sequence for use in the detection of cancer cells in a biological sample.
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Quantitative Three-dimensional Mapping of Oxygen Tension

Methods and apparatus are disclosed for measuring and mapping oxygen tension in a tissue and, in particular, permit direct non-invasive measurement of retinal tissue oxygen tension. In one aspect, the invention is directed to methods for determining oxygen tension in a target tissue sensitized with an oxygen sensitive probe by imaging the target tissue. In one embodiment, the invention provides a noninvasive method for monitoring oxygen tension in a chorioretinal tissue sensitized with an oxygen
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Temporal Release of Growth Factors from 3d Micro Rod Scaffolds for Tissue Regeneration

The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders.
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Methods and Devices for Capturing Circulating Tumor Cells

A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device.
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Compositions and Methods for Quantitatively Monitoring Lipids

Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding.
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Non-invasive Optical Imaging for Measuring Pulse and Arterial Elasticity in the Brain

An optical imaging system and a method for generating a report regarding elasticity of arteries in the brain of a subject under test. Light output from the light source of the imaging system non-invasively illuminates at least one blood vessel or region of interest in the brain and, upon the interaction with the vessel, is registered with an optical detector to obtain a shape parameter of a hemodynamic pulse in the vessel. The shape parameter is further correlated to an elasticity parameter of t
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Apparatus for Managing a Neurological Disorder

A system that incorporates teachings of the present disclosure may include, for example, a Neuro Sensing and Stimulation Device having a conductive lead for implanting in a brain of a living entity, a sensor coupled to the conductive lead for collecting data associated with one or more electrical signals detected in the conductive lead, a stimulator coupled to the conductive lead to apply one or more electrical signals thereto, and a controller. The controller can be operable to collect data ass
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Apparatus for Biomedical Imaging

A system that incorporates teachings of the present disclosure may include, for example, a method involving capturing spectral interference from an optical coherence tomography imaging probe comprising a micro-electro-mechanical system (MEMS) scanning mirror, and a partial reflector for supplying images to an image sensor. Additional embodiments are disclosed.
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Method for Multi-scale Meshing of Branching Biological Structures

A structural and functional model for a lung or similar organ is virtually defined by encoding aspects of branching passageways. Larger passageways that are visible in medical images are surface mesh fitted to the anatomical surface geometry. Smaller distal passageways, beyond a given number of branch generations, are modeled by inference as linear passages with nominal diameters and branching characteristics, virtually filling the space within the outer envelope of the organ. The model encodes
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Contact Tracking Using Wireless Badges

This application discusses apparatus and methods for tracking contacts between various entities in a region. An apparatus includes portable transceiver device having a radio, memory and a power supply. The portable transceiver device can detect and record a history of proximity to other transceiver devices. The portable transceiver device can receive information related to disease exposure of the transceiver device and can include a processing component to compute an exposure potential to a cont
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Hybrid Laser Ophthalmoscope

Provided is a hybrid laser ophthalmoscope comprising a laser light source, a LED light source, and a holographic diffuser, wherein the holographic diffuser is configured to shape a beam of light into a Maxwellian ring.
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Biologically Active Molecules, Particularly Based on PNA and siRNA, Method for the Cell-specific Activation Thereof, and Application Kit to Be Administered

Biologically active molecules are inactivated for selective activation by target cells by being covalently bonded to one or more peptides each of which has one or more specific amino acid sequences that are selected in respect of enzymes cell-specific for target cells. The bonds, which are broken exclusively by the enzymes cell-specific for the target cells in order to biologically activate the molecules, allow the molecules to remain biologically inactive in cells other than the target cells. T
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Method and Apparatus for Mapping a Structure

A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An impla
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Mri Contrast Using High Transverse Relaxation Rate Contrast Agent

This document discloses, among other things, a system and method of creating a positive contrast magnetic resonance imaging (MRI) feature using a high transverse relaxation rate contrast agent.
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Coil Element Decoupling for MRI

An RF coil adjacent an imaging region includes a plurality of conducting coil elements, with each conducting coil element including a proximal portion and a distal portion. The RF coil also includes a capacitance between the distal portions of the at least two conducting coil elements. A mutual coupling inductance between at least two conducting coil elements of the plurality of conducting coil elements is substantially cancelled by the capacitance between the distal portions of the at least two
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Improved Monitor of Heart Failure Using Bioimpedance

In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a third electrode in the superior vena cava, where the voltage potential is created by the electrical current. Pulmonary edema is assessed based on an impedance value calculated from the electrical cur
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Sensing Tissue Properties

A sensor (100) for in-vivo tissue elasticity measurement is disclosed. The sensor utilises a micro-fabricated structure comprising multiple membranes (120a-c) with varying stiffness and is particularly designed for integration coupled to a medical instrument, such as a probe, an endoscopic tool, or another minimally invasive, instrument. Preferably, the sensor comprises an array of MEMS capacitive sensors fabricated using surface micromachining.
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Automatic Measurement of Speech Fluency

Techniques are described for automatically measuring fluency of a patient's speech based on prosodic characteristics thereof. The prosodic characteristics may include statistics regarding silent pauses, filled pauses, repetitions, or fundamental frequency of the patient's speech. The statistics may include a count, average number of occurrences, duration, average duration, frequency of occurrence, standard deviation, or other statistics. In one embodiment, a method includes receiving an audio sa
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Methods and Systems for Chemical Ablation

Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.
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Combination Localization System

A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.
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Thermochemical Ablation System Using Heat from Delivery of Electrophiles

Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. The chemical reaction energy is provided by chemical reactions including a highly reactive electrophilic reagent provided to a target tissue location.
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Dipole Matched Filter for MRI

A method includes receiving k-space data corresponding to magnetic resonance data for a subject and selecting a template for analysis. In addition, the method includes generating an image using the k-space data and using the template.
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Process for Producing a Hyper-Elastic, High Strength Dilatation Balloon Made from Multi-Block Copolymers

A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates, during inflation, a true stress vs. nominal strain response curve comprising a first zone representative of a low modulus balloon, a second zone representative of a high strength balloon, and a sharp
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Tracking and Representation of Multi-dimensional Organs

A method includes receiving data corresponding to a sequence of deformations of a surface of an object. The method also includes generating spherical harmonics expressions based on the data. The method includes identifying a subspace of the spherical harmonics expression corresponding to the surface.
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Method for the Production of Bacterially Synthesized Cellulose and Cellulose-containing Material in a Planar Form

The invention relates to a method for producing bacterially synthesized cellulose and cellulose-containing material in a planar form. The aim of the invention is to devise a universally usable method that is suitable for large-scale production and allows homogeneous, planar bacterially synthesized cellulose and cellulose-containing materials to be efficiently produced at any defined length and thickness, regardless of the reactor geometry. Said aim is achieved by removing the bacterial cellulose
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Process and System for Manufacturing a Customized Orthosis

A process and system for fitting, customizing and manufacturing an orthosis for a subject. 3-dimensional coordinates for a plurality of landmarks corresponding to anatomical characteristics of the subject, means for attachment of the orthosis to the subject, and a reference plane are digitally acquired. Then, coordinates of one or more virtual landmarks corresponding to one or more anatomical joint centers or joint projection locations are calculated. The landmarks are clinically aligned in a re
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Upper Arm Wearable Exoskeleton

An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a first motor output coupled to the first cuff. A second motor is mounted on the third cuff and has a second motor output coupled to the second cuff. A processor is operatively coupled to the first and sec
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Evaluating Magnetic Resonance Spectra

Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various constituents (e.g., metabolites, macromolecules) of the sample.
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Methods of Identifying Safe NMDA Receptor Antagonists.

Processes are providedfor the identifcation a compound that is useful to treat or prevent a disorder that lowers the pH in a region of affected tissue comprising assessing the difference in potency, or potency boost, of the compound at physiological pH versus disorder-induced pH in a cell that expresses a human NMDA receptor. The assessment of potency boost can include measuring an IC50 of a compound at physiological pH and at disorder-induced pH (the "potency boost") until a 95% confidence inte
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Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle

Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumf
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Compositions, Materials Incorporating the Compositions, and Methods of Using the Compositions and Materials

The invention relates to composition and methods of using described compositions as oxidative catalysis. In certain embodiments, the invention relates to a composition having a nitrogen oxide species, bromide ion, a metal, and oxygen. In certain embodiments, the composition catalyzes sulfides.
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Composite Biomimetic Materials

In an embodiment, composite materials having a fiber of relatively high Young's modulus is embedded in an elastin mimetic material with a relatively low Young's modulus. In an embodiment, the fiber is crimped so as to provide a composite material having a non-linear stress-strain curve, with an initial Young's modulus at lower strains that is less than the Young's modulus at higher strains. The composite materials are optionally formed into medical devices. Further provided are methods of making
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Microelectrode Stimulation for Treatment of Epilepsy Or Other Neurologic Disorder

Methods for treating a neurologic disorder by neurostimulation. The stimulation may be applied using electromagnetic energy. In certain embodiments, distributed electrical stimulation is applied to a target site of the brain in an ongoing fashion. A microelectrode array may be used to provide the distributed electrical stimulation. The method may also comprise the detection of electrophysiologic signals from the brain. These detected signals may be analyzed and used for closed-loop feedback of t
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Self-Anchoring MEMS Intrafascicular Neural Electrode

The present invention provides a self anchoring electrode for recording, measuring and/or stimulating nerve activity in nerves and/or nerve fascicles of the peripheral nervous system, and methods for using such a self anchoring electrode.
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Device and Method for the Study of Cell and Tissue Function

A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when close
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Methods and Devices for Modulating Cellular Activity Using Ultrasound

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating
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Neural Interface Assembly and Method for Making and Implanting the Same

An implant assembly for creating a neural interface with a central nervous system having at least one biocompatible intracortical electrode is presented along with a method of making and implanting device. The mechanical, electrical and biological characteristics of the assembly support its use as a reliable long term implant.
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Reusable Biosensor Platform

Techniques, apparatus and systems are described for generating reusable and reconfigurable biosensors. A microfluidic device includes a substrate layer and an electrode layer disposed above the substrate layer. A spacer layer is disposed above the electrode layers to form at least two channels. Another electrode layer is disposed above the spacer layer. Also, another substrate layer is disposed above the other electrode layer. The other substrate layer can include at least two inlets, each conne
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Systems, and Methods for Neurostimulation and Neurotelemetry Using Semiconductor Diode Systems

Methods and systems for neurostimulation and/or neurotelemetry of electrically-excitable biological tissue. Embodiments include implanting single or multiple semiconductor diodes and applying a high frequency electrical volume current. Neurostimulation embodiments include local rectification of the volume current by the diode, which can provide a pulsating electrical waveform capable of locally stimulating neural tissue, hi neurotelemetry embodiments, semiconductor diodes can be placed in contac
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Digital Amplification

The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reli
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Cylindrical Illumination Confocal Spectroscopy System

A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample through the objective lens unit, and a detection system in optical communication with the objective lens unit to receive at least a portion of light that passes through the objective lens unit from the sa
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Platelet Function Analysis for Adverse Cardiovascular Events

The present invention relates to methods, compositions, assays and kits for identifying individuals with elevated risk of experiencing an adverse cardiovascular event after coronary or peripheral arterial bypass graft surgery. In particular, the invention relates to a method for identifying an individual at elevated risk for vein graft occlusion after coronary artery or peripheral bypass graft surgery comprising conducting a platelet function analysis.
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System and Method for Sharing Medical Information

A system and method for sharing information, comprising: creating at least one problem-oriented record utilizing at least one modifier to describe at least one attribute of at feast one problem; and utilizing the at least one problem-oriented record to share information.
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Optical imaging or spectroscopy systems and methods

Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incide
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Bioreactor System for Mechanical Stimulation of Biological Samples

The subject application provides an apparatus for applying mechanical loading to a biological sample, said apparatus comprising: a bioreactor device configured to house the biological sample, and a load application unit for applying mechanical loading to the biological sample housed in the bioreactor device, said load application unit including: a) a first sliding arm for applying mechanical displacement to the biological sample in the bioreactor device in a first predetermined direction; and b)
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Cellular labeling for nuclear magnetic resonance techniques

The disclosure provides, in part, fluorocarbon imaging reagents and formulations for the ex vivo labeling of cells. Labeled cells may be detected in vivo or ex vivo by a nuclear magnetic resonance technique, such as magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). The disclosure additionally provides methods for using the imaging reagents in a variety of clinical procedures.
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Magnetically-levitated Blood Pump with Optimization Method Enabling Miniaturization

A magnetically-levitated blood pump with an optimization method that enables miniaturization and supercritical operation. The blood pump includes an optimized annular blood gap that increases blood flow and also provides a reduction in bearing stiffness among the permanent magnet bearings. Sensors are configured and placed optimally to provide space savings for the motor and magnet sections of the blood pump. Rotor mass is increased by providing permanent magnet placement deep within the rotor e
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Multi-linked Endoscopic Device with Spherical Distal Assembly

A device for performing a procedure may include an elongate tube having a proximal end and a distal end and an adapted link having a proximal end and a distal end. The distal end may include a first mating surface, where the proximal end may be configured to attach to the distal end of the elongate tube. The device may also include a rotating link having a second mating surface configured to rotatably interface with the adapted link first mating surface.
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A Device for Transfecting Cells Using Shock Waves Generated By the Ignition of Nanoenergetic Materials

A miniature device for generating shock waves using the energy of combustion of a nanoenergetic material and directing the shock waves into biological tissues is described.
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Photoacoustic Detection of Analytes in Solid Tissue and Detection System

A preferred system for detecting an analyte in solid tissue (12), such as an intact lymph node, in vitro includes a laser (22) arranged to generate a pulsed laser beam into solid tissue, which can be a fully intact lymph node. An acoustic sensor, and preferably at least three acoustic sensors (20a, 20b, 20c) are arranged in different positions to span a three dimensional space, such as in an X, Y and Z coordinate system, to detect photoacoustic signals generated within the lymph node. At least o
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Optical Spectroscopy Device for Non-invasive Blood Glucose Detection and Associated Method of Use

An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a su
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Method and Apparatus for Cancer Screening

A method and apparatus for detection of pteridine levels in a biological sample using CE-LIF which is useful for early cancer screening involving fully oxidizing pteridine compounds in a sample such as a urine sample, subjecting to CE-LIF to assess compound concentration, and compare to expected levels in for healthy or cancer-bearing patients.
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Method and System for Non-invasive Optical Blood Glucose Detection Utilizing Spectral Data Analysis

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood in a sample. Disclosed techniques include (1) using a standard deviation operation in conjunction with the logarithm function, (2) using a normalization factor, (3) using a ratio factor, (4) accounting
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Controllable Magnetic Source to Fixture Intracorporeal Apparatus

A first magnetic field can be produced across a tissue region using a first magnetic field source, providing a magnetic coupling force between the first magnetic field source and a first object, wherein the first object provides a magnetic field or a magnetic susceptibility to obtain the magnetic coupling force. The magnetic coupling force can be sensed using a force sensor and a resulting sensed force signal can be provided to a controller. The controller can provide an output signal to control
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Methods, Devices, and Systems for Bone Tissue Engineering Using a Bioreactor

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image -based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusio
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Methods, Devices, and Systems for Chemiluminescence-based Microfluidic Cell Counting

A chemiluminescence-based detection system and method for counting blood cells by capturing and isolating target blood cells flowing through a microfluidic chip and detecting light emitted by the captured target blood cells.
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Filter Blood Fluid Channel Methods, Devices and Systems

A risk of thrombogenesis is minimized in a tubular fiber membrane filter by flowing blood or other fluid through a header manifold that ensures a minimum shear rate on the wetted surfaces without flow reversal, stagnation volumes, or a shear rate that is too high. In an embodiment, fluid is conveyed into a header space and into a manifold face at a perimeter of the header space. The header space has a progressively decreasing clearance that is minimal to provide for substantial shear rate and de
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Systems and Methods of Microfluidic Membraneless Exchange Using Filtration of Extraction Outlet Streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary
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Multi-layer Blood Component Exchange Devices, Systems, and Methods

A microfluidic separation device suitable for high throughput applications such as medical treatments, and associated methods and systems, are described. Embodiments are suitable for treatment of end stage renal disease.
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Systems and Methods for Dynamic Imaging of Tissue Using Digital Optical Tomography

A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of attenuated optical signals exiting the tissue to obtain a plurality of analog signals containing diffuse optical tomographic information; converting the analog signals into digital signals; recovering
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Active Cmos Sensor Array for Electrochemical Biomolecular Detection

Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical
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Methods, Apparatus and Systems for Magnetics Stimulation

A coil suitable for tissue stimulation and especially for transcranial magnetic stimulation (TMS) may be used in conjunction with a pulse generator to induce electric field in the brain with less attenuation in depth compared to existing TMS coils. In an example, a coil winding is formed in a solenoid configuration around the head. Various related features, methods, and embodiments are described.
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Fluid Separation Devices, Systems and Methods

A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic body-free plasma flow and remaining fraction, and a dialysate-free second stage, which selectively removes excess fluid, toxins and other substances from the plasma flow and returns the processed pla
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Systems, Methods, and Devices for Microbubbles

A suspension of gas-filled microbubbles can be synthesized by sonicating a lipid solution and a first gas in a reaction volume. The resulting microbubble suspension can be stored for later use, for example, for infusion into a patient for gas delivery thereto. Various techniques can improve the shelf life of the microbubbles. For example, the microbubble suspension can be freeze-dried to remove water and the first gas therefrom while leaving the microbubble shells intact. In an alternative, the
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Device, Apparatus and Method for Providing Photostimulation and Imaging of Structures

According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI- glutamate and/or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up
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Improved Apparatus and Method for Assessing Visual Learning

An improved test apparatus and method for assessing visual learning in mammals is provided. The stimuli presented to the mammal are disposed and arranged on the floor of the test apparatus instead of on the walls.
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Method and Apparatus for Model-based Detection of Structure in Projection Data

In one aspect, a method and apparatus for determining a value for at least one parameter of a configuration of a model associated with structure of which view data has been obtained including detecting at least one feature in the view data, and determining the value for the at least one parameter of the configuration of the model based at least in part on the at least one feature. In another aspect, a method and apparatus for detecting at least one blood vessel from object view data obtained fro
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Systems for and Methods of Assessing Urinary Flow Rate Via Sound Analysis

Systems for and methods of assessing urinary flow rate via sound analysis. Embodiments of the uroflow measurement systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The uroflow measurement systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based uroflow software application for viewing the resu
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Breath Biofeedback System and Method

A breath biofeedback method and system for encouraging a subject to modify respiration. The system includes a thoracic volume input module measuring thoracic volume data of the subject and a pattern module providing target breathing patterns in communication with a display generator. The display generator producing display information representing a displayable image including a first object having a first position determined as a function of the thoracic volume data and a second object having a
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Systems for and Methods of Assessing Lower Urinary Tract Function Via Sound Analysis

Systems for and methods of assessing lower urinary tract function from urinary flow data via sound analysis and user-provided information regarding the lower urinary tract symptoms (LUTS) of frequency, urgency and urge incontinence. Embodiments of the LUTS assessment systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The LUTS assessment systems may include sound analysis
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Methods, devices and apparatus for imaging for reconstructing a 3-D image of an area of interest

Featured are methods, devices and apparatuses for imaging tissue, such as cardiac tissue, using any of a number of imaging techniques (e.g., ultrasonic imaging techniques) and a 3-D tracking system. In embodiments, such methods, devices and apparatuses are configured so that a 3-D image can be reconstructed from image data acquired at different locations from the image data and three dimensional coordinates that are determined for each location whereat the imaging device was located.
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Device for Perineal Massage and Method of Use

A number of studies have been performed that demonstrate beneficial effects of perineal dilation and/or massage during pregnancy to reduce episiotomy and perineal trauma at birth. The invention includes a perineal massage device including a retractor portion attached to the unified end of a bifurcated handle. The device can be held anteriorly or posteriorly by the user. The device facilitates perineal massage during the last portion of pregnancy when the enlarged abdomen restricts easy access by
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Method and System for Detecting Lung Tumors and Nodules

A method and system for detecting tumors and nodules in a lung tissue are provided. The method includes the steps of (a) providing a plurality of asymmetric templates of at least one 3D appearance model of a nodule; (b) providing a 3D imaging data set of the entire area of a tissue; (c) matching the 3D imaging data set of the entire area of the tissue with each of the plurality of asymmetric templates to search for 3D objects in the tissue that match the at least one 3D appearance model; (d) det
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Pulse Measurement Apparatus and Method

An embodiment of the invention is directed to a pulse measuring system that measures a characteristic of an input pulse under test, particularly the pulse shape of a single-shot, nano-second duration, high shape-contrast optical or electrical pulse. An exemplary system includes a multi-stage, passive pulse replicator, wherein each successive stage introduces a fixed time delay to the input pulse under test, a repetitively-gated electronic sampling apparatus that acquires the pulse train includin
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Medical Apparatuses Incorporating Dyes

The invention provided medical apparatuses incorporating dyes to facilitate proper positioning in patients, and methods for their use. The apparatuses can be, for example, tubes, catheters, or needles. In some embodiments, the dye is a near infrared fluorescent dye.
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Method for Controlling Photodynamic Therapy Irradiation and Related Instrumentation

In a first embodiment, there is no monitoring, and instead light is delivered according to a predetermined "recipe." In a second embodiment, the instrumentation provides a means for making the reflectance measurements during therapy without requiring the brief interruption. This device may therefore allow more accurate measurement of treatment-induced changes to the reflectance measurement. In a third embodiment, an adjustable aperture is used to constrict the area of a treatment beam.
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Automated Placental Measurement

A method for analyzing the placenta in two or three dimensions comprising: selecting one or more placenta! samples to be analyzed; obtaining a digital image of each placenta! sample: and performing an analysis on the digital images, wherein a mathematical algorithm is applied to the digital image, The results of the analysis are correlated with data on health outcomes in infants, children, or adults and are used to assess future health risks to a patient.
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Methods and Apparatus for Differential Phase-contrast Fan Beam Ct, Cone-beam Ct and Hybrid Cone-beam Ct

A device for imaging an object, such as for breast imaging, includes a gantry frame having mounted thereon an x-ray source, a source grating, a holder or other place for the object to be imaged, a phase grating, an analyzer grating, and an x-ray detector. The device images objects by differential-phase-contrast cone-beam computed tomography. A hybrid system includes sources and detectors for both conventional and differential-phase-contrast computed tomography.
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Method and Apparatus of Cone Beam Ct Dynamic Imaging

A cone-beam scanning system scans along a half circle. The reconstruction uses a weighting function which decreases for rows farther from the scan plane to take the redundancy of the projection data into account. Another embodiment uses a circle plus sparse helical scan geometry. Image data can be taken in real time.
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Photoacoustic Imaging Using a Versatile Acoustic Lens

To image various soft tissues in the body using pulsed laser optical excitation delivered through a multi-mode optical fiber to create photoacoustic impulses, and then image the generated photoacoustic impulses with an acoustic detector array, a probe includes either a mirror and an acoustic lens or a special acoustic lens of variable focal length and magnification that can operate in a liquid environment that is aberration-corrected to a sufficient degree that high resolution images can be obta
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Low-cost Device for C-scan Photoacoustic Imaging

The prostate gland or other region of interest is stimulated with laser light, resulting in ultrasound waves (photoacoustic effect) which are focused by an acoustic lens and captured by a specific 1- or 2D sensor array and subsequently displayed as a C-scan on a computer screen. The amplitude of the ultrasound waves generated by laser stimulation is proportional to the optical absorption of the tissue element at that spatial location. Variability in tissue absorption results in C-scan image cont
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Respiratory Disease Monitoring System

An automated system for monitoring respiratory diseases, such as asthma, provides noninvasive, multimodal monitoring of respiratory signs and symptoms that can include wheeze and cough. Some embodiments employ a mobile device, such as a cell phone, in which raw data from a microphone and an accelerometer are processed, analyzed, and stored. Data can be collected continuously. Time domain and frequency domain analyses of signals to determine, e.g., energy, duration, and spectral content of candid
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Robotic Localizing Aid for High Intensity Focused Ultrasound Delivery

A holding structure holds a biopsy needle and a HIFU transducer to allow smooth and accurate delivery of the HIFU beam at the interface of the liver, where bleeding will occur. This manipulator structure performs the biopsy and HIFU through the percutaneous approach. In addition, the procedure is imaged by an imaging ultrasound probe. The imaging ultrasound probe can track the needle entry site even when needle has been removed. The HIFU transducer fires a short pulse of HIFU in the needle tract
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Apparatus and method for cone beam volume computed tomography breast imaging

Cone beam volume CT breast imaging is performed with a gantry frame on which a cone-beam radiation source and a digital area detector are mounted. The patient rests on an ergonomically designed table with a hole or two holes to allow one breast or two breasts to extend through the table such that the gantry frame surrounds that breast. The breast hole is surrounded by a bowl so that the entire breast can be exposed to the cone beam. Spectral and compensation filters are used to improve the chara
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High-frequency Oscillatory Ventilation Monitoring Method and System

A method of monitoring high frequency oscillatory ventilation (HFOV) wherein the oscillatory movement of the chest wall of an individual is measured. An average amplitude is determined and compared to a pre-determined baseline amplitude, which is established by using the average amplitude at a particular instant of time. If the variance between the average amplitude and the baseline meets and/or exceeds a pre-determined threshold above or below the baseline value, an operator is alerted.
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Magnetic Tweezers Method to Measure Single Molecule Torque

A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device.
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Decontamination Apparatus

A decontamination apparatus including an enclosure, a first and second decontamination system within the enclosure where the first and second decontamination systems rely on different methods of decontamination.
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Cerebral Vascular Reactivity Monitoring

A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The correlation may be used to assess vascular reactivity.
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Extracorporeal Organ Conservation

The invention relates to an arrangement for extracorporeal organ conservation. Said type of arrangements are used to artificially preserve or to regenerate vital functions of organs, said organs also having extremities and tissue lobes. The inventive arrangement for extracorporeal organ conservation is made of at least one organ perfusion chamber (1) provided with an adjustable temperature device (3). An organ (2) is arranged in said organ perfusion chamber (1), said organ being surrounded by a
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New vaccine strains having two or three different attenuation active metabolic drift mutations, which result in smaller colonies with corresponding longer generation time and correlated attenuation de

Vaccine strains having two or three different attenuation active metabolic drift mutations, which result in smaller colonies with correspondingly longer generation times and correlated attenuation degree, with respect to reduced growth intensity, against the respective wild strains, are new. An independent claim is included for the preparation of the vaccine strains. - ACTIVITY : Antibacterial; Fungicide; Antidiarrheic. - MECHANISM OF ACTION : Vaccine.
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Modular System of Functional Units for Mixing, Processing And/or Separating Samples for Use in Biological/medical Research and for Diagnostics

Basic steps of biological research and of diagnostics include mixing, physical and/or chemical reactions and separation. Particularly in research task-specific laboratory systems are required which are not commercially available due to small batch sizes and the specific problems to be faced. Because of the lack of such systems, researchers and diagnosticians have to improvise with already existing vessels, filters, centrifuges etc. to solve the problems. The aim of the invention is to devise a s
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Aurora Kinase Inhibitors Compounds.

The present invention relates to novel compounds of formula (I) that inhibit cell proliferation, in particular by inhibiting selectively Aurora A kinase activity and to their use in medicine, in particular for treating, ameliorating or preventing hyperproliferative diseases. The invention further relate to methods of their preparation, pharmaceutical compositions including such compounds.
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Bi-plane X-ray Imaging System

A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of nearly any motion or joint. The radiographic equipment can be mounted in a gantry system that provides sufficient positioning flexibility for imaging different joints of a subject's body, along with an imaging area large enough for a variety of dynamic activities (e.g., walking, running, jumping, throwing,
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Manipulation, Detection, and Assay of Small Scale Biological Particles

Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. A particle manipulation device contains a plurality of electrodes formed on an active semiconductor layer of an integrated circuit chip, where the electrodes and gap spacing between adjacent electrodes is submicron in size. The chip is oriented with its substrate face up, and at least a portion of the substrate is removed from the chip so the electrodes are in close proximity
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Method and System for Acquiring Loundness Level Information

The present invention relates to methods for acquiring hearing threshold values in a subject comprising providing a sound to the subject; providing a monitor for monitoring a movement response by the subject; monitoring the movement response by the subject to the sound; and progressively reducing the volume of the sound until no movement response by the subject to the sound occurs. The present invention further relates to methods and systems for acquiring loudness level information for a subject
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Non-contact Frequency Domain Near Infrared Absorption (inir) Device for Assessing Tissue Damage

A device for measuring the progress of healing of a wound over time includes at least one diode laser source that provides respective input wavelengths into at least one source fiber, a first optical switch that sequentially switches wavelengths among the respective input wavelengths into the at least one source fiber, a probe that does not touch the wound dunng use, the probe including the at least one source fiber and at least two detectors spaced thereon, an optical system that provides sourc
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Tubular Floating Electrode Dielectric Barrier Discharge for Applications in Sterilization and Tissue Bonding

Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the gas. The RF electrode, disposed circumferentially proximate to the exterior of the dielectric conduit, generates non-thermal plasma from the ionized gas. The non-therm
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System and Method for Evaluating Tissue

A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.
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Control of Mucus Membrane Bleeding with Cold Plasma

The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is par
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Methods for Beaming

Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.
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Nucleic Acid Expression Construct and Its Use As a Cell Proliferation Marker

In a first aspect, the present invention provides a nucleic acid expression construct encoding a fusion protein comprising a reporter protein and a protein with a wild-type destruction signal, wherein the sequence encoding the fusion protein is operably linked to a non-endogenous promoter, and wherein the fusion protein localizes during cell cycle progression to subcellular structures selected from the group consisting of the cell cortex, the contractile ring, and the midbody. In a further aspec
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Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer

The present invention discloses compositions of facially amphiphilic polymers and oligomers and their use in methods for treating or reducing cancers in humans or animals.
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Methods for Making Embryonic Cells, Embryos, and Animals Sensitized to Stress

Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a secondary treatment with a stress inducer, e.g. heat shock or chemical inducer. Accordingly, the present invention is directed to methods for making embryos, embryonic cells arising from them, and animals and plants that are sensitized to stress, e.g. physiologic or chemical stressors. Methods of screen
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Porous Expansion Bolt

A biocompatible expansion bolt includes a central screw and an expansion shell positioned about the central screw. The expansion shell is shaped and dimensioned for controlled expansion between a first diameter and a larger, second diameter, wherein die expansion shell is composed of porous material allowing for tissue in-growth.
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Ribosome structure and protein synthesis inhibitors

The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhi
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Protein Chip for Screening of Protein Activity

The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention
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Apparatus, Systems and Methods Utilizing Plethysmographic Data

Disclosed are apparatus, systems and methods utilizing attributes of the cardiac signal to calibrate/normalize components of the plethysmographic (PG) waveform indicating changes in venous and arterial blood volume. In the time-domain, amplitudes of respiratory-induced variations of the DC and AC components of the PG waveform may be calibrated/normalized based on an average amplitude of the PG waveform, e.g., over a respiratory cycle. Similarly, in the frequency domain, respiratory signal streng
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Dynamic Spine Stabilizer

A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured spine. The dynamic spine stabilizer includes a support assembly and a resistance assembly associated with the support assembly. The resistance assembly generates greater increase in mechanical force during movement within the central zone and lesser increase in mechanical force during movement beyond the ce
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Microrna Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors

The invention provides a papillary serous miRNA signature and methods for determining the identity, origin, and stage, of concurrent endometrial and ovarian papillary serous tumors. Exemplary origins of concurrent endometrial and ovarian tumors include, but are not limited to, the uterus, ovary, fallopian tubes, and peritoneum.
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Smart Structures for Bone Prosthesis

This invention relates to structures to be applied in bone prostheses and it refers to a multi-network concept of biosensors and bioactuators that continually and actively monitor the performance and integrity of bone implants inside living organisms. The biosensors network contemplates different sensor technologies (optical, piezoresistive piezoelectric and piroelectrical), which allow a real-time implant monitoring, during and after the surgery, the actuator network consisting of biomimetic ma
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Intracellular Device which Can Be Used As a Biological Activity Sensor Element Or Actuator

The invention relates to an intracellular device which can be used as a biological activity sensor element or actuator, formed by or based on silicon (monocrystalline silicon with crystallographic orientation (100), polysilicon or silicon oxide), having lateral physical dimensions of between 50 nanometres and 5 micrometres and a thickness of between 20 nanometres and 2 micrometres. The surface(s) of the device can be functionalised by coating same with chemical compounds, fluorescent molecules,
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Flourinated material

This invention relates to a method for modifying the surface of a material for use with a biological sample or tissue comprising the steps of providing a material having a surface which comprises reactive-functional groups; providing fluorinated molecules having reactive-functional groups complimentary to those on the material surface; using wet chemistry to attach the fluorinated molecules to the surface of the material by reacting the reactive-functional groups of the implant with the compleme
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Targeted Induction of Aggregation of Proteins with Cross Beta Structures

The present invention belongs to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as aggregator, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such aggregator molecules and their use in therapeutic and diagnostic applications.
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Single Domain Antibodies Capable of Modulating Bace Activity

The present invention relates to single domain antibodies with a specificity for BACE1. More specifically, the invention provides single variable domain antibodies derived from camelids which bind to BACE1 and are capable of inhibiting the activity of BACE1. Said antibodies can be used for research and medical applications. Specific applications include the use of BACE1 specific antibodies for the treatment of Alzheimer's disease.
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Multifunctional Stealth Nanoparticles for Biomedical Use

The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an ex
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Gallium-doped Phosphocalcic Compounds

The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7, wherein 0 < x < 1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).
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Bacteria Having Protecting Activity Against Botrytis Cinerea

The invention relates to bacteria having protecting activity against Botrytis cinerea: said bacteria are selected from the strains Acinetobacter, Bacillus, Pantoea and Pseudomonas. Application in the biological control of Botrytis cinerea.
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Method of Toxicological Assessment

A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function; and correlating the measured data of the at least one parameter of cellular function with toxicity, wherein the step of exposing the cells to the candidate agent is carried out in the presence of a reagent capable of f
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Capillary electrochromatography (CEC) analytical separation analysis device and method

A capillary electrochromatography (CEO) analytical separation analysis device. The device comprises a stationary phase fabricated at least partially from a conducting or electroactive polymer e.g. polyaniline (PANI). By applying a potential to the stationary phase it is possible to modify or control properties of the stationary phase e.g. porosity, density, hydrophobicity or colour etc.
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Amnion Epithelial Cells for the Treatment of Degenerative Disc Disease

An orthopaedic device and methods for the treatment of degenerative disc disease (DDD) are disclosed that utilise cells such as multipotent amnion epithelial cells (AECs) and/or mesenchymal stem cells (MSCs) that may be directed towards a disc cartilage type cell for the in situ generation of intervertebral disc (IVD)-like tissue. In some embodiments, derivative cells of multipotent AECs and/or MSCs may be used.
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Platelet Aggregation Using a Microfluidics Device

A microfluidics device to provide real time monitoring of platelet aggregation of a biological sample obtained from a subject. The device comprises a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region of shear deceleration and defining there-between a region of peak rate of shear, the downstream region of shear deceleration defining a zone of platelet aggregation
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Antibody

The invention relates to antibodies to Aspergillus species and to methods of producing those antibodies. The invention also relates to the use of such antibodies in identifying the presence of the Aspergillus species and to methods of treating an infection with the Aspergillus species.
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Photonic Biosensor Arrays

This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising a transparent substrate having a surface bearing a plurality of assay spots for plasmon resonance sensing, each of said assay spots comprising a discrete metallic island, a said metallic island compr
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Method for Fabrication of Photonic Biosensor Arrays

This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field. A method for the fabrication of a biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the method comprising: (i) providing a transparent substrate; ii) providing seed metallic nanoparticles in the form of a colloid; (iii) depositing said colloid as discrete metallic islands on
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Method for Producing Multiple Modifications in the Chromosome of Gram-negative Bacteria and Salmonella Strains which Are Deficient in C-di-GMP Synthesis Obtained By Said Method

The method can be used to make multiple modifications in the genome of Gram-negative bacteria, simply and efficiently, using the plasmids of the invention, which comprise a marker gene under the control of a constitutive promoter, a replication origin specific for Gram-negative bacteria, a gene which encodes a heat-sensitive protein essential for initiating replication of the plasmid, making the replication origin heat-sensitive, and a counter-selection gene. The invention also relates to mutant
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Antimicrobial Composition

The invention provides antimicrobial compositions comprising a terpenoid in combination with an antimicrobial agent, and uses of such compositions in various applications involving preventing, combating or treating microbial infections, or preventing microbial growth or establishment.
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Process for Providing Embryonic Stem Cells

Embryonic stem sells, particularly human embryonic stem cells are outstandingly sought as subjects of research owing to their capability for reproduction and differentiation in many, if not in all, cell types in a body. Herewith described invention in the application reveals the procedure according to which embryos, development of which has been interrupted, can be used for obtaining embryonic stem cells.
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Controlled Production and Delivery of Biologically Active Agents By Gut Bacteria

The invention provides gut commensal bacteria that have been modified to express one or more biologically active polypeptides or protiens, the bacteria includes a promoter, such as a xylanase promoter, which is induced in response to the presence of xylan in the diet and which regulates the expression of the biologically active polypeptide or protien.
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Human Immune Therapies Using a CD27 Agonist Alone Or in Combination with Other Immune Modulators

Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one CD27 agonist, preferably an agonistic CD27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an a
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Total Plasma FVI I /FVI IA Levels As Indicators of Pre-eclampsia of Pregnant Females

Raised total plasma FVII protein, including activated FVII (FVIIa) in pregnant females, compared with total plasma FVII protein in normal pregnancy, has been found to be an indicator of the pregnancy complication of pre-eclampsia.
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Materials and Methods Relating to Cell Based Therapies

The invention relates to the provision of a novel cell population that can be used for tissue regeneration and the treatment of disease states associated with cell degeneration for age related tissue changes. The cell population are derived from adult stem/progenitor cells which are characterised by being positive or negative to the Thyl.1 cell marker.
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Methods of Analysing Homeostatic State in Cell Systems

The invention relates to a method of analysing the homeostatic balance of a population of cells, which includes the following steps: a) label one or more cells in the population b) incubate the cells for a time t c) determine the clone size distribution of labelled cells at time t d) determine if the clone size distribution of (c) conforms to the scaling formula (I): where Pn(t) is the probability of finding a surviving clone which has n progenitor cells at time t, formula (II) denotes the avera
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Transgenic rodent expressing truncated disc 1

The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia- related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncatedDisc1genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc 1 polypeptide truncated before exon 9; (2) 2 copies of endogenousDisc1genomic DNA sequence encoding fu
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Magnetically-controlled micro-fluid system for e.g. 'lab-on-chip' system for determination of presence of bio-molecules, virus, biological cells

A micro-fluid system transports tiny particulate quantities of a biological or pharmaceutical liquid sample through a channel exposed to the effect of a magnetic force generated nearby. The channel is exposed to two or more magnetic sources, each separated from the other. - The magnetic force is generated by an electro-magnet by a spiral micro-coil. The coil longitudinal axis runs along or is transverse to the micro-channel. The coil has a core whose tip is directed at the micro-channel. The mag
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Method and Reagent for the Specific Identification and Quantification of One Or More Proteins in a Sample Using in Particular Inductively Coupled Plasma-mass Spectrometry

The invention relates to a method for the identification and quantification of one or more biomolecules in a sample containing a mixture of substances, wherein said method comprises the steps of, a) providing a sample which contains one or more biomolecules, b) providing a reagent for the analysis of biomolecules according to Formula I (A-Y-PRG) wherein, A may be present or absent and when A is present, A is H or constitutes at least one functional group for the reversible, covalent or non-coval
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Microginin Producing Proteins and Nucleic Acids Encoding a Microginin Gene Cluster as well as Methods for Creating Novel Microginins

The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature.
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Chitosan Green Tea Polyphenol Complex for Wound Healing

In recent years, oxidative stress has been implicated in a variety of degenerative process and diseases, including acute and chronic inflammatory conditions such as wound healing. Green tea polyphenols have shown anti-oxidant property. The present study discussed the application of chitosan green tea polyphenol complex on the wound healing.In my research, chitosan polyphenol complex has enhanced the healing of incision wounds by increasing the breaking strength of the wounds. In excision wound
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Label-Free Protein Detection

Background Conventional methods to detect the presence or quantity of specific proteins or other molecules in biological samples rely on the use of target-specific probes such as antibodies, which can be detected via chemical tags or fluorescent labels. However, conjugating labels to proteins can alter the functional properties of a probe and thus a number of label-free methods to detect proteins such as the use of functionalized silicon nano-wires or carbon nano-tubes have been developed. How
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A Novel Therapeutic Strategy for HIV Infection

BACKGROUND: Tat is an HIV regulatory protein that is essential for viral replication and HIV disease progression. It critically regulates HIV transcription and allows the generation of full-length transcripts necessary for the formation of virus particles. Tat is also found in the circulation and can enter uninfected cells in an active form. Thus, Tat plays a role in the immune dysregulation and death of infected and uninfected T cells, helping to explain why the number of T cells that die each
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Moisture-Resistant Adhesive Polypeptides

BACKGROUND: Surgical tissue adhesives provide an alternative to suturing, packing, or stapling planes of tissue together. Use of adhesives for wound closure is desirable since adhesives can be very fast acting and assure complete closure. Marine adhesives (such as those used by barnacles) can function over wide temperature ranges, fluctuating salinities, humidities, and under strong currents. These glues are able to rapidly form permanent bonds to a wide variety of substances with complex and of
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Sol-gel-coated Implantable Devices

Highlights Method for coating uneven surfaces with sol-gel polymers Current coating methods unable to provide complete, uniform coating of non-contiguous surfaces such as those found in stents and orthopaedic screws Sol-gel polymers can incorporate therapeutic, antibacterial, or other materials that prevent corrosion, biofouling, or restenosis Our Innovation Electro-deposition of biocompatible sol-gel for coating complex surfaces such as those found on implantable medical devices. Efficien
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Quantum Dot Processing

Background Semiconductor nanocrystals, or quantum dots (QDs) have received great interest from the biological and medical communities in the last few years. This interest can be largely attributed to the unique optical and electronic properties of QDs and their advantageous properties over organic-based fluorophores for many biological applications. QDs have high luminescence (1 QD = 10 to 20 fluorophores), high resistance to photobleaching, narrow spectral linewidths, and size and materials
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Integrated Fluidics System for Simplifier Analysis of Aerosolize Biological Particles

An integrated fluidics system for simplified analysis of aerosolize biological particles has a unitary self-contained ticket provided with a sample fluid reservoir, an array of particle-detection strips, which is located adjacent to the sample reservoir, and, optionally, a cleaning fluid reservoir and an impinging nozzle. The fluidics system is, thus, configured to substantially minimize the fluid paths between the components of the system. Patent Status: U.S. patent(s) 6796164 issued.
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Novel Patterning Techniques for DNA-sensing Microarray Fabrication

DNA microarrays typically consist of a glass slide with an array of polyacrylamide gel pads. One commercially available microarray coats a glass slide with acrylamide gel, then photopolymerizing the acrylamide to create the array of square pads. “Probe” DNA is deposited and linked to the polyacrylamide gel pads, using a pin-robot or jet printer. This microarray is associated with a large background fluorescence signal. Another commercially available microarray utilizes a pin-robot, which
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DNA Sensor with Electronic Transduction

Fluorescence-based detection of nucleic acid has several drawbacks. First, it requires that fluorescent tags be chemically attached to target nucleic acid. Next, fluorescent tags have a lifetime, after which they bleach, which limits sensitivity and archiving. Finally, fluorescent readout technology requires a laser and optical system. Thus, in order to eliminate the necessity of fluorescently tagging target nucleic acid, which requires chemical steps before analyte is brought to a sensor, t
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Purification and Concentration of Proteins from Complex Samples Using Aptamers and the Interaction between Nucleic Acids and Silica

There is a need for an inexpensive, efficient, automated device for the preparation and analysis of samples that comprise both DNA and proteins. Generic methods for the purification of DNA from cells or mixtures of cells include alcohol precipitation, silicon binding, standard gel electrophoresis, and phenol extraction. Most of these methods are time consuming and must currently be performed manually. Proteins, however, have no equivalent for specific detection and have very different structu
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Microfabricated Substrate for the Collection of DNA (Micro-sandpaper)

-------------------------------------------------------------------------------- Microfabricated Substrate for the Collection of DNA (Micro-sandpaper) Reference#: P02331 -------------------------------------------------------------------------------- Conventional forensic DNA detection technologies require hair, skin, blood, or tissue samples to be taken from people in order to be processed. This is commonly done using a mouth swab or blood sample. Low copy number DNA analysis tec
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Intelligent Fusion of Multi-modal Biometric Inputs for Decision Making

While techniques provide some beneficial results, they do not effectively utilize all of the information available to a score-level fusion system, including score values, quality estimates, and score distribution statistics. APL's Process for Multi-Biometric Fusion provides expandable, Bayesian belief network-based architecture for multimodal biometric fusion. Studies have been carried out using the architecture to fuse fingerprints and voice data. This invention is unique because: 1) the me
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Thermally Induced Decontamination Environments

Current Environmental Decontamination technologies require chemical approaches or alternately require extremely high temperatures. Chemicals used tend to be hazardous and costly to the environment or the targeted area. Paraformaldehyde gas, glutaraldehyde, hydrogen peroxide and peracetic acid also work, and need to be in contact with spores for at least as long. But these materials can be corrosive and are not appropriate for many areas. High temperatures of greater than 100 degrees C are often
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Wireless Wearable Electronic Tags for Patient Triage

For years, emergency medical response teams have relied on paper triage tags, clipboards of notes, and voice communications (using telephones and hand-held radios) to share patient information. This workflow, however, has proven labor intensive, time consuming and prone to human error. With the start of the twenty-first century, there has been an increasing concern about hospitals around the nation and their ability to handle incoming surges of patients. The inadequate tools, growing patient pop
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An Unclad Fiber Optic Sensor for Measuring Chromophoric Compounds in Human Blood and Amniotic Fluid

Yellow or brown tinged skin and eyes are the hallmarks of jaundice – seen most often in infants. The yellowing is a result of elevated levels of a substance called bilirubin in the blood (hyperbilirubinemia). Hyperbilirubinemia is commonly seen in 50-70 percent of newborn babies and is the most common reason for hospital readmission for newborns. In many cases, this jaundice appears about 2-5 days after birth, is a result of inadequate processing of normal red blood cell breakdown by the liver
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Enhanced Optical Methods to Break Spore Coating

There is a need for rapid and accurate detection of bacterial spores such as Bacillus anthracis. Currently, two detection techniques are being used to rapidly identify bacterial spores. These techniques are MALDI_MS and PCR-amplification. These techniques identify the spores by evaluating biomarkers inside the cell. Both of these methods require spore disruption to release biological biomarkers before the identification can take place. This invention is a novel method to open spore coatings a
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Electrode Array to Determine Specific Axonal Firing in a Peripheral Nerve

Researchers and scientists at the APL have been trying to find better ways to communicate amputees’ brains with the reflexive movements of their missing parts – ways that are reliable, precisely coordinated and non-invasive. Under normal circumstances, our brain indicates actions that should take place. An electrochemical signal travels along complex communication channels in our body, called neurons, and eventually, in the case of movement, stimulates specific muscles to enact precise movem
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Using Wearable Biometrics for Continuous Automated Authentication

Biometrics use biological features such as fingerprints to determine an individual’s identity by comparing the observed fingertip patterns to a previously stored pattern. Biometrics are useful for controlling access to devices - such as laptops - or to facilities. One drawback, however, is the user-intrusive action required, such as placing a finger on a sensor for scanning or positioning the eye close to an iris scanner. The intrusiveness of a biometric scan can be especially cumbersome durin
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Assisted Drug Delivery Device

Transporting drugs to specific and appropriate tissues of the body is not a trivial issue and can be more important than the benefits of the drug itself. Characteristics of the target tissue and of the drug chemistry must be considered before a treatment can be effective. Delivery issues are largely linked with the drug’s stability, mechanisms for metabolism of each drug, the tolerance and reaction of the body to the drug and the permeability of the target tissue. Engineering this reaction is
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Soluble, Processible Molecularly Imprinted Macromolecules

The scientific community's excitement for the use of molecularly imprinted polymers (MIPS) for sensors and filters is rising at an almost exponential rate, with the practical realization that plastics holding impressions of molecules could revolutionize many important aspects of drug discovery, medical diagnostics, chemical analysis and environmental science. Molecular imprinting is a technique for preparing synthetic polymers with recognition sites specific for a target molecule. These artifici
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Variable Angle Linear Slot Scanning Digital X-ray Device

This new, multipurpose device allows a greater number of radiologic studies from a single machine. In addition to the functionality of conventional digital x-ray and tomography machines, the linear slot scanning feature of this unique device will also allow full body x-ray scans, x-ray scans of specific areas, and angled x-ray scans. Angled x-ray scans of areas of interest can be achieved in an axial, lateral, or axiolateral orientation up to 45 degrees from perpendicular, in any direction a
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X-Ray Cassette Alignment and Centering System

The x-ray department is a principle source of income for hospitals and private practices. On average, 6% to 10% of all x-rays need to be repeated to produce an acceptably diagnostic radiograph. Of these repeat exams, most are for chest, abdomen, pelvis and spinal imaging. A primary reason for this repeat rate is improper x-ray cassette alignment. Incorporation of this alignment and centering technology will help reduce the average rate that x-rays need to be repeated thereby saving the facility
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Ocular and Microsurgery Device Controlled by Artificial Muscles

Minimally invasive surgery techniques are less traumatic to the patient. They are significantly less painful, provide less chance of infection, less post-operative services and generally make recovery easier and faster. The breakthrough technologies that make operating procedures more efficient and safer are constantly being modified and improved upon. Electroactive polymers (EAPs) are an emerging class of functional materials that respond to stimulation with specific movement. This attractive c
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Pressurized Drinking System (PDS)

Your heart is beating as the alarm signal continues to bleat out its warning, which for you – a bio-chemical specialist with the military fighting forces – means you need to suit up and report directly to the hazardous environment where you will be required to assess and remediate the nuclear, chemical or biological event. While everyone else is being evacuated, you are heading straight towards the deadly hazard. Although you have practiced repeatedly, you still struggle to don the life-savi
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MRI Flex Circuit Catheter Imaging Coil

There is a need for higher resolution imaging of heart tissue particularly for treating arrhythmias and atrial fibrillation using catheter ablation methods. While cardiac electrodes for measuring voltage potentials due to arrhythmias have been performed before using a flex circuit, the use of flex circuitry for an MRI receive coil (deployed within the heart) is a novel and unique way of imaging heart tissue. The Johns Hopkins University Applied Physics Laboratory has developed a narrow, thin
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Non-invasive Health Monitor

The APL Non-Invasive Health Monitor, in its various forms, will provide a method of evaluating cardiovascular and respiratory status, and autonomic balance and therefore provide insight into physiological or psychological stressors that may be negatively impacting the health of the individual. The sensor may be used for passive, long term monitoring to acquire data for trend analysis, or may be used in a manner similar to that of the stethoscope for the generation of information that is complime
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A Microfabricated Array Sensor for the Electrochemical Detection of Biological Molecules

The ability to detect ultra low concentrations of heme and hemoglobin in bodily fluids has great value in clinical and medical diagnostic applications. Clinical screening for many diseases, such as colorectal cancer and malaria, is predominantly related to the concentrations of hemoglobin or heme in different biofluids. The detection of porphyrins in urine, saliva, cerebrospinal fluid and swabs from the nasopharyngeal cavity may also be used to indicate infection, trauma or other frank diseases.
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Adaptive Analysis Framework

This technology, the Adaptive Analysis Framework (AAF) is a novel design and maintenance plan for large databases associated with biological and medical research problems or clinical assessments that make use of large scale data sources within multiple and separate laboratory facilities. The framework manages and assists the collection, analysis and storage of immense and distributed sets of data and helps establish protocols for new research projects. While the application focuses on biological
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A New Class of Anticancer Drugs

Adrenocortical carcinoma generally carries a poor prognosis. No effective therapies have emerged to treat or cure this disease. Radical surgical excision is the treatment of choice for cancers that have not spread to other organs. Surgery is the treatment of choice, except when there is evidence of distant spread Unresectable or widespread tumors may be palliated by anti-hormonal therapy with mitotane, systemic chemotherapy, or radiation therapy. Despite these treatments, survival for patient
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Combined Chemical/Biological Agent Detection by Mass Spectrometry

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and is patenting a mass spectrometer for combined chemical
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Autonomous Ingestible Probe for Diagnosis and Therapy of Gastrointestinal Lesions Using Fluorescent Molecules

Current technology for diagnosis and therapy of gastrointestinal lesions has no ability for functional imaging, has limited specificity of tumors, no therapeutic capability, and provides no assessment of treatment efficacy. The Johns Hopkins University Applied Physics Lab has developed a “pill” that, when swallowed, produces functional images of the intestinal track for diagnosis and therapy. This form of functional imaging identifies specific molecular structures in the intestinal wall.
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The Use of Laser Desorption and Matrix Assisted Laser Desorption Ionization Mass Spectrometry for the Detection of Occult Blood in Biomedical Applications

Methods are described for detecting and quantifying occult blood in a biological sample using laser desorption mass spectrometry (LD MS). Biological samples that can be analyzed using various embodiments of the present invention include stool (fecal occult blood, FOB), and any bodily fluid including urine, cerebrospinal fluid and other bodily fluids. If the heme or heme metabolite is bound to protein, the sample is treated with acid before analysis to release the porphyrin. Some of the methods u
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A Highly Sensitive Procedure for the Detection of Blood in Stool for Indications of Colon Cancer, Internal Bleeding, Disease and Other Traumas

Malaria is a debilitating, infectious disease characterized by chills, shaking and periodic bouts of intense fever. Each year, there are an estimated 400 million to 600 million cases of malaria and 2.7 million resulting deaths, worldwide. Malaria is found in many locations of the tropical world and in some locations of the subtropics, but there are only four species of the single-celled parasite of the genus Plasmodium that infect humans and cause the disease. Westerners who visit malarious coun
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Cortisol Sensor for Soldier Stress and Fatigue Monitoring

The hormone cortisol, which is produced by the adrenal gland and is released in the body during stressed or agitated states, has gained widespread attention as the so-called "stress hormone." But this hormone is more than a simple marker of stress levels- it is necessary for the functioning of almost every part of the body. Excesses or deficiencies of this crucial hormone also lead to various physical symptoms and disease states. This compound has been studied as a biomarker for many diseases su
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Surface Structure Measurement Device

Current means of assessing surface roughness at the 5 micrometer scale size and at surface roughnesses of a few micrometers consist of stylus probes or optical scatterometers. Such devices are not practical for measurement of tooth surface structure in vivo. The Johns Hopkins University Applied Physics Laboratory researchers have developed a concept that provides a convenient means of assessing surface roughness of teeth. The JHU/APL technology provides an optical measurement of tooth surface
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Remote Screening and Diagnosis of Malaria and Other Blood Borne Parasites

Malaria is a debilitating, infectious disease characterized by chills, shaking and periodic bouts of intense fever. Each year, there are an estimated 400 million to 600 million cases of malaria and 2.7 million resulting deaths, worldwide. Malaria is found in many locations of the tropical world and in some locations of the subtropics, but there are only four species of the single-celled parasite of the genus Plasmodium that infect humans and cause the disease. Westerners who visit malarious coun
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Methods and Devices for Detection and Diagnosis of Malaria

Malaria is a debilitating, infectious disease characterized by chills, shaking and periodic bouts of intense fever. Each year, there are an estimated 400 million to 600 million cases of malaria and 2.7 million resulting deaths, worldwide. Malaria is found in many locations of the tropical world and in some locations of the subtropics. Each year, travelers who visit malarious countries return home and are hospitalized with malaria. Malaria was the number one cause of hospitalization among America
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Low-cost Flexible Manufacturing Techniques for Bradbury-Neilson Gates and Similar Interdigital Structures for Use in Miniature Time-of-Flight Mass Spectrometers and Other Related Applications

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and is patenting techniques and methods for using precisio
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Portable Ventilator with a Manifold-Muffler System

Portable ventilators are self-contained, lightweight life support devices used to provide ventilation, oxygen and diagnostic capabilities at the scene of an accident- when it is most critically needed - which substantially reduces fatalities. This novel component reduces the ventilator’s size and weight by organizing and consolidating the vast internal tubing, while minimizing noise. Patent Status: U.S. patent(s) 7032589 issued.
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Techniques for Deriving Tissue Structure from Multiple Projection, Dual-Energy X-ray Absorptiometry

The present invention relates to dual-energy x-ray absorptiometry for tissue properties; and, in particular to techniques for deriving bone structure, bone strength, and risk of injury, including risk of fracture, from multiple projection dual-energy x-ray absorptionmetry images. Patent Status: U.S. patent(s) 6816564 issued.
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Patient Initiated Emergency Response System (PIERS)

More than one million Americans will suffer an acute myocardial infarction (AMI) this year. Within the first 60 minutes of chest pain, 250,000 will die. Before reaching any medical attention, a total of 375,000, (one-third) will die. Current studies strongly suggest that time-to-treatment is an important predictor of mortality in AMI and efforts aimed at reducing the delay between AMI onset and therapy can reduce mortality significantly. Thus, strategies having even a small relative benefit in t
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Patient Initiated Emergency Response System (PIERS)

More than one million Americans will suffer an acute myocardial infarction (AMI) this year. Within the first 60 minutes of chest pain, 250,000 will die. Before reaching any medical attention, a total of 375,000, (one-third) will die. Current studies strongly suggest that time-to-treatment is an important predictor of mortality in AMI and efforts aimed at reducing the delay between AMI onset and therapy can reduce mortality significantly. Thus, strategies having even a small relative benefit in t
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Large Region Spatio-Temporal Biosurveillance System

There are significant limitations with previous attempts at constructing early warning bio-surveillance systems. Conventional bio-surveillance focuses on categorical data collected from emergency rooms, clinics, and other healthcare facilities. The detection algorithms in these conventional systems rely on threshold crossing algorithms applied to single streams of data. Such an approach does not make optimal use of available information and cannot detect a bio-terrorist attack until sizeable num
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Ambulatory Health Monitor

The Ambulatory Health Monitor is a miniaturized, self-programmable, stand-alone device that logs changes in various physiological parameters over extended periods of time. The data collected by the monitor can be easily downloaded to a remote device. With the proper sensors, the monitor can collect and store an athlete’s skin temperature, pulse rate, and blood pressure during training. This ambulatory health monitor collects data continuously so that an athlete would not need to interrupt
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Thermal Pain Probe

The loss of nerve fiber density or function, neuropathy, can result from disease or injury such as diabetes or burns. Assessment of the response of small nerve fibers found in the skin can indicate the degree of damage and the effects of treatment. JHU/APL has developed a handheld device to deliver a very specific heat stimulus to these small nerves. Through precise control of the temperature, area and size of application and duration of the stimulus, a thermal pain threshold can be determine
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Blood Iron Removal for Suffers of Hemochromatosis Using a Selectively Permeable Molecularly Imprinted Polymer Dialysis Membrane

The ability to remove a specific component from its environment has immediate and profound applicability on environmental and medical fronts. Currently, filtering devices that can selectively and completely remove environmental phosphate and nitrate do not exist. Present systems are able to achieve level of 1 mg of phosphorus per liter of water and about 80% nitrogen free. The system described below has the potential to reduce contaminant concentrations to any arbitrary level through staging
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The Cardiac Auscultatory Recording Database (CARD): an Internet-based Software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation

Current medical training techniques rely on significant patient contact, resulting in high training costs and often not the expected outcomes. In a 1997 study published in The Journal of American Medical Association, researchers found that on average, internal medicine and family practice residents (all four years) recognized only 20% of the common cardiac problems that could be diagnosed using a stethoscope; the cardiac auscultation skills of 198 internal medicine and 255 family practice reside
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Airborne Pathogen Neutralization

So far there is no effective way to disinfect or neutralize airborne pathogens in large volumes of contaminated air in real time to protect citizens against a terrorist attack using biological weapons, or to disinfect air in hospitals. The present inventions provide an apparatus and methods for neutralizing airborne pathogens in large volumes of ventilated air in real time, which is effective against airborne pathogenic bacteria, spores and viruses. The technology is based on the formation of
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Intra- and Inter-Body Wireless Communication and Modular-Payload Capsules

Current "capsule cam" type technologies typically use electromagnetic radiation with limited payloads and provide one-way communication. The JHU/APL "Intra- and Inter-Body Wireless Communication and Modular-Payload Capsules" technology eliminates the exposure to electromagnetic radiation, provides flexibility in the payload options, and offers two-way communication. The JHU/APL invention provides a means for "wireless" communications within the human body and from inside the body to external
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Method and Apparatus for Imaging and Spectroscopy of Tumors and Determination of the Efficacy of Anti-tumor Drug Therapies

Cancerous tumor growth is dependent on a process called angiogenesis wherein factors secreted by a tumor cause surrounding normal tissue to produce new blood vessels that enter the tumor and support its growth. This so-called neovascular growth is essential to tumor survival and growth. They also represent an internal energy source that heats the tumor and causes it to emit infrared radiation at rates different than surrounding tissue. The net emission and its wavelength response depends on the
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Refreshable Tactile Computer Display for the Blind

To make computer systems accessible to visually impaired users, a tactile display with multiple tactile elements that can be touched by a user serves many purposes. A tactile display with two positions for the tactile elements (raised and lowered) can be used to form Braille characters that can be scanned by a trained user more rapidly than a speech synthesizer can pronounce the same material. A tactile display with contiguous tactile elements that each can assume one of two positions can for
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Use of Cytokines and Other Host Cell Response Molecules Collected from Breath as Non-Invasive Method to Detect Infectious Disease

A novel non-invasive point-of-care method to rapidly assess for disease is being developed. The exhaled breath condensate is the non-gaseous portion of the breath that is made up of aerosolized fluids and proteins secreted from the epithelial cells that line the walls of the lung. If properly collected and analyzed, researchers will be able to measure, map and study the presence and patterns of cytokines and their specific relationships to cellular immunological responses that occurs in disease
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Transdermal Optical Communication System

applications of medical devices, telemedicine, and wireless medical diagnostics, there is the need to communicate with such devices implanted in the human body. The Johns Hopkins University Applied Physics Lab has conceived a method to communicate via optical link through the skin. An information modulated two-way optical link will lie quiescent until activated by a “wake-up” transmission to the data exchange circuitry, specific data will then be transmitted to and from the implanted dev
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Plasminogen Activator to Prevent Haze After Laser Eye Surgery

Some fraction of patients who have laser vision correction develop haze (cloudy vision) several months after the surgery: about 8% to 10% of photorefractive keratectomy (PRK) patients and a smaller fraction of laser in situ keratomileusis (LASIK) patients. At present there is no pre-surgical predictor for the potential formation of haze, nor a preventative to eliminate the haze. A Johns Hopkins University Applied Physics Laboratory researcher, in collaboration with researchers in the Department
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Time-of-Flight Mass Spectrometer Array (TOF Spectrarray)

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and patented a minimization of the TOF Mass spectrometer w
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The TeleWatch Patient Monitoring System

The Johns Hopkins Medical Institutions, Division of Cardiology and The Johns Hopkins Applied Physics Laboratory have developed medical procedures and associated telehealth system capabilities for the home monitoring and disease management of high risk outpatients suffering from congestive heart failure. Effective management of congestive heart failure (CHF) is one of the most important challenges and opportunities confronting our health care delivery system. Despite landmark basic and clinical r
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Field-Portable Time-of-Flight Mass Spectrometer System

A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a
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Improvement in Performance of a Microchannel Plate Detector Assembly Using a Miniature Anode (Micro-node)

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and patented an improved version of commercially available
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Information Technology in Support of Early Detection of Bioterrorist Events

Recent history demonstrates that weapons of mass destruction can be built and deployed by almost any individual or group that has an intent to cause harm or that is looking for media attention for its cause. The arsenal of weapons available to the terrorist includes chemical and biological agents. These weapons, banned from wartime usage, have nevertheless proliferated in third world countries. Information on the development and deployment of these weapons has become widely available on the Inte
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Low Pressure Electronically Controlled Valve

low-pressure valve enabling precise control of a fluid flow rate through the valve during cyclical operation of the valve. The valve is useful for controlling air delivery to a patient as part of a portable ventilator. The valve comprises a housing having an inlet 16 and two outlets 18 and 20. A wiper plate 22 and an orifice plate 24 are disposed inside of the housing. Transverse movement of the wiper plate 22 relative to the orifice plate 24, powered for example by a servomotor 34, simultaneou
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Clinician's Portable, Digital, Intelligent Assistant (Pain Informatics Program)

The input devices are mobile pen-based computers and palm pad systems that will emulate and expand the clinician’s present paper patient system. The system will provide for semi-automation of the collection, archiving, and retrieval of patient information. The Pain Informatics system provides medical personnel with an organized, efficient and reliable method of completing all patient information electronically. This system can improve the accuracy and reliability of patient data collection and
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Assessment of Tooth Structure Using Laser Based Ultrasonics

Dental health care and research workers require a means of imaging the structures within teeth in vivo. For example, there is a need to image the margins of a restoration for the detection of poor bonding or voids between the restorative material and the dentin. With conventional x-ray techniques, it is difficult to detect cracks and to visualize interfaces between hard media. This is due to the x-ray providing only a 2 dimensional projection of the internal structure (i.e. a silhouette). In add
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Device for Rendering an Injection Syringe Single-Use Only

single-use, self-annulling syringe is disclosed that is rendered inoperative after a single use without requiring any deliberate action on the part of the user. The injection device uses a hydrophilic expansion plug positioned in the outlet flow channel of the syringe, which expands a short time after being exposed to a drug containing water, thereby rendering the syringe inoperative.
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Database and Knowledge-base Enhancements

Healthcare costs continue to escalate at a steep rate. Cost increases have occurred in all areas, including insurance premiums, medical equipment, medicines and costs for visits to doctors. A great deal of energy has gone into finding ways to reduce healthcare costs, from government control of aspects of health care to insurance company managed care plans to control patient utilization of the healthcare system and provider actions. The present invention provides protocols and environment for
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Cross-hatched, focused, x-ray scatter reduction grid fabricated by lamination technique

An X-ray scatter reduction grid includes a first layer having a plurality of cells. The cells have a perimeter formed of an X-ray absorbing material. The shape of the perimeters can vary, but a polygonal shape is preferred. The grid can also include other layers, each with their own cells. The cells of the subsequent other layers are larger than and offset from the cells of the prior layer. The increased size of the cells allows a primary ray passing through the center of a first layer cell to a
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A Gridless, Focusing Ion Source for a Time-of-Flight Mass Spectrometer

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and patented (1) a grid-less, focusing ionization extracti
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Catalytic Inhibitor for Use in Anhydrous Ammonia to Counter Illicit Drug Manufacture

A method of inhibiting or preventing the use of anhydrous ammonia as a solvent in a dissolving metal reduction process comprises adding to anhydrous ammonia a chemical reagent which is capable of scavenging solvated electrons generated when alkali or alkaline earth metal is dissolved in the anhydrous ammonia, the chemical reagent being added to the anhydrous ammonia such that when alkali metal is dissolved in the anhydrous ammonia containing the chemical reagent and thereafter ephedrine, pseudoe
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Rapid Chest Tube Inserter

Current chest tube insertion techniques are lengthy and require extensive training and experience. The Rapid Chest Tube Inserter enables a simple, rapid and safe insertion of a chest tube (or other types of drains) that is firm and stable. This technology extends the ability to insert the chest tube to trained emergency medical personnel other than experienced doctors. Key issues for chest tube insertion include location, penetration angle, control of depth of insertion (to minimize the risk
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Simple and Modular Reflectron Construction Using Flexible Circuit Board Material

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and patented a multi-layered reflectron for a time-of-flig
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DEXA Scanner System

A light weight, high resolution and precision, dual energy X-ray absorptions scanner for determining bone geometry and mass is needed. Inventors at the Johns Hopkins University Applied Physics Laboratory have developed a scanner that will be suitable for traditional and spaceflight uses requiring accurate bone and muscle mass measurements. This unit will have the precision required to detect changes in bone mass and geometry as small as 1% and changes in muscle mass as small as 5%. Target wei
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Eye Fixation Monitor and Tracker

Apparatus and method are provided for assessing the direction of fixation of an eye by detecting polarization-related changes in light retroreflected from the fundus of the eye. Nerve fibers in the retina of the eye are birefringent and alter the polarization state of light traversing them as function of their orientation. The nerve fibers are arrayed in a characteristic pattern in the retina, specifically radiating outward from the fovea and converging to the optic nerve head. By assessment of
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Vestibular Irrigator Test System (VITS)

Caloric tests that irrigate the inner ear are often used as a first "reflex" type diagnostic when patients complain of dizziness (dizziness being the second most common cause of visits to general practices). The current caloric tests often require more than 1/2 hour to execute and the patients often leave feeling nauseated. That is because at least four irrigatios are required and it takes about 12 minutes for the stimulus (warm or cold water in the inner ear) to dissipate between irrigations.
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Emergency Life Support System

The invention comprises an emergency life support system including a patient ventilator for mechanical breathing assistance. The preferred embodiment uses an oxygen generator to deliver oxygen, to generate electric power to run the ventilation system, and to warm IV fluids and resuscitated air. Patent Status: U.S. patent(s) 6848444 issued. International patents pending.
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Noninvasive Magnetic Sensing of Human Prostate Tumor

Despite the ability of noninvasive electromagnetic bioimpedance methods to measure low contrast changes in tissue, a perennial problem has been the precise localization of the change. Generally, the interrogation or sampling volume is gauged by the diameter of the coil used to impart the electrical signal to the tissue. Because of the intervening tissue between the coil and the region under study (e.g., skin, muscle, bone), it is difficult to precisely locate the depth of the physiological chang
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Immunoaffinity Fluorometric Biosensor

The Immunoaffinity Fluorometric Biosensor is a hand-held, self-contained, automatic, low-power and rapid sensor platform for detecting and quantifying a plurality of analytes. This sensor platform (with the appropriate modifications) has been used to detect low levels of NADH; poly aromatic hydrocarbons (PAHs); and aflatoxin, the fungus-produced carcinogen found in peanuts, corn, and other grains. The biosensor operates on the principles of immuno-affinity for specificity and fluorescence for
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Video Ophthalmoscope with Single-Adjustment Focus

The invention is a hand-held ophthalmoscope modified by the removal or augmentation of the focusing wheel and the addition of a manual or automatic focusing lens system. An electronic imager (CCD array or video camera) is placed optically conjugate to a viewing screen such that focus operations performed by the examiner to adjust the image seen by the examiner on the screen also focuses the image on the electronic imager. This is accomplished by an optical system which includes a straight path f
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Friction Transmission with Axial Loading and a Radiolucent Surgical Needle Driver

Conventional needle driving techniques are based on holding the needle head and not the barrel of the needle, the motion of the needle being induced by moving the support of the needle head. The above technique does not allow radiolucent constructions. Moreover, supporting the needle from its head tends to disadvantageously maximize the unsupported length of the needle, thus facilitating needle deflection under the insertion force. An object of the present invention is to provide a simple and
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Intravenous Feed Anchor System (IVFAS)

IV treatment, administered on an inpatient or outpatient basis, is often interrupted by unintentional movement, blockage or removal of the IV from the patient. These very serious interruptions often create force on the IV supply line and can result in loss of IV dispensed fluids disrupting patient care. In addition, breakage of the IV needle causes both patient discomfort and the need for immediate attention by the medical staff. The above situations could be remedied by attaching a safety devic
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Passive Method to Objectively Quantify the Level and Density of a Neural Blockade

A critically important factor in current surgical/medical device design is the market demand for minimally invasive or non-invasive procedures. APL’s invention addresses that market need. From the issued patent Electromyogram (EMG), temperature, and heart rate measurements, which correlate to the dermatomal level and density of neural blockade, are obtained in a passive manner, i.e., the patient is not stimulated or exposed to any sensor that requires an active conduction in order to make a
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Optimization of Radiation Treatment Planning

An algorithm applied in the radiological treatment of tumors that minimizes a cost function that is quadratic in the residual between the prescribed dose distribution and the calculated resultant dose. Possible treatment arcs must be stipulated and the algorithm includes an automatic technique for multiple iso-center selection. One overall strategy can be specification of an unrealistically large number of beams (or arcs) and systematic deletion of those beams having the smallest recommended wei
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Methods and Apparatus for Improved Visualization of Choroidal Blood Flow and Aberrant Vascular Structures in the Eye

There is very little information about the blood flow through capillary plexuses which occurs on the time scale of the cardiac cycle. In part this is because direct visualization of such plexuses usually is technologically difficult or impossible, and most blood flow measurement methodologies require that data be obtained over many cardiac cycles. Moreover, when the capillary plexuses have complex vascular geometries and are fed by many arterioles, the additional problem of sorting-out blood flo
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Optical Feature Extraction Apparatus and Encoding Method for Detection of DNA Sequences

APL engineers have developed an optical imaging device that uses video display, spatial light modulation, and detection components, in conjunction with microlenslet replicating optics, to expedite the recognition of symbol sequences based on their symmetrical properties. Multichannel operation is achieved through the replication of input scenery, making possible a higher throughput rate than for single channel systems. The invention's design facilitates flexible queries of large databases of var
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Method and System for Automated Detection of Microcalcification Clusters in Mammograms

The invention is a novel method for automated detection of objects in images. One specific use is to detect malignant microcalcification clusters in mammograms. The method operates by forming a contour plot of the image (mammogram), the object (microcalcification) in the contour plot being comprised of a set of nested contour lines wherein the contour lines correspond to intensity levels thereby causing the object to appear as a prominent peak in relation to the local surround in the image.
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Method and Apparatus to Identify and Treat Neovascular Membranes in the Eye

Associated with a number of pathological conditions is the growth of ocular neovascular membranes. These membranes are often in close proximity to the sensory retina of the eye. If the abnormality arises from the retinal vessels, it is called a retinal neovascularization. If it is from the choroidal vessels, it is called a choroidal neovascularization (CNV). Both kinds of neovascularizations can diminish vision: in the case of retinal neovascularization by blocking light focused by the eye's len
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Bone Substitute for Training and Testing

Training and testing of orthopaedic procedures and devices. This material can be used as a non-Biohazard replacement for real bone and can be manufactured to provide consistent performance. Can be used to develop and test new procedures, devices, and tools for use on bone. Based on the failure to achieve the equivalent drilling loads found in human bone when using various fillers in a resin matrix, the new concept would use a sintered ceramic material with known porosity to represent the skel
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Automatic Detection of Seizures Using Electroencephalographic Signals

patient monitoring system and a method of activating it were developed. The system automatically detects a seizure in the patient by detecting an electrical discharge in the patient's brain. It then converts the detected electrical discharge into a digital signal and inputs the signal into a microprocessor. The system detects a seizure by dividing the digital signals into time segments, preprocessing each time segment (including standardizing the signal), and reducing the signal in each time se
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Minimum Interface Biomedical Monitoring System

The present invention is a universal interface allowing a main implant to supply power and receive data from remotely implanted sensor modules through a minimum number of interconnecting lines. The main module can supply a single DC voltage, two sequentially applied DC voltages, or an AC voltage to the sensor module. A capacitor means in the sensor module supplies power while the sensor module is transmitting data.
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Non-Invasive Electromagnetic Technique for Monitoring Physiological Changes in the Brain

None of the previous technologies contemplate measuring localized impedance changes in the brain to evaluate physiological changes in the brain, such as the occurrence of edematous tissue, and none of the references teach an apparatus capable of such spatially localized impedance measurements. Applicant was the first to discover that edematous tissue has a significantly different conductivity (or impedance) from normal white or grey brain matter. Applicant believes that edematous tissue is f
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Vascular Averting Instrument

The invention concerns a means having two instruments for averting an end of a severed artery over a ferrule surrounding the artery. A handle of a flaring instrument is squeezed to rotate a head section. Arms mounted to the head section open in the manner of an iris-diaphragm mechanism to flare the arterial end. Another instrument, curved forceps, urges the artery via the ferrule into the head section such that the arterial end is averted over the ferrule. Two averted arterial ends may be joined
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Apparatus for Inhibiting Self-Injurious Behavior (SIB) in Patients

An improved apparatus for inhibiting self-injurious behavior (SIB) in patients includes a stimulus module for generating and applying an aversive electrical stimulation to the patient's skin and a sensor module and/or remote actuator for actuating the stimulus module in response to a patient's self-injurious behavior. The apparatus uses a near-field magnetic link to transmit a coded signal from a sensor module or from a remote actuator to the stimulus module worn on the patient. The stimulus mod
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Prosthetic Elbow with a Motor-driven Release Mechanism

The invention concerns a releasing means for a prosthetic elbow locking mechanism. When an elbow unlocking cable is tensed by the amputee, a switch is closed, triggering a one-shot circuit. The one-shot circuit emits a single pulse, which drives the motor of the prosthetic elbow, turning the motor a few degrees and lifting the arm such that any frictional engagement between an elbow locking pawl and an elbow gear is relaxed. The locking pawl is readily withdrawn from engagement with the gear, on
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Method for Clearing a Gas Bubble from a Positive Displacement Pump Contained within a Fluid Dispensing System

A method and apparatus for removing gas bubbles from the fluid handling system of a medication infusion system are disclosed. Specifically, the invention discloses a method for removing fluid and/or gas bubbles from a fluid reservoir and pumping chamber. The present invention utilizes a fluid pump of a single-valve positive displacement design with the pump chamber in fluid communication with the fluid reservoir
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Single Valve Diaphragm Pump with Decreased Sensitivity to Ambient Conditions

A single valve diaphragm pump is disclosed which generally includes: a pump housing, a flexible diaphragm reciprocally movable in the pump housing, an inlet filter means, and an outlet valve. The flexible diaphragm conforms in shape to a portion of the pump housing when the diaphragm is in its actuation or rest position. The pump eliminates an inlet check valve and replaces it with an inlet filter means. The invented pump has a stroke volume, which is extremely constant even though ambient press
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Manually Actuated Hydraulic Sphincter

An implantable hydraulic urinary sphincter system is disclosed for maintaining continence in those patients unable to control or stop inadvertent urinary flow. The invented apparatus generally consists of an artificial urinary sphincter and a control means for automatically increasing or decreasing sphincter pressure with sensed bladder and/or intra-abdominal pressure. An improved mechanical actuation means is also disclosed which allows the patient to urinate. To urinate, the patient presses a
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Plural Module Medication Delivery System

The invention is a system consisting of a multiplicity of separate modules, which collectively perform a useful biomedical purpose, the modules communicating with each other without the use of interconnecting wires. All modules may be intracorporeal or body-mounted extracorporeal, or some modules may be intracorporeal with others being body-mounted extracorporeal. Signals are sent from one module to another by electromagnetic waves, by electrical signals using the body as an electrical conductor
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Self-Injurious Behavior Inhibiting System

An apparatus for preventing self-injurious behavior in patients is disclosed. The apparatus generally contains one or more sensor modules, which detect self-injurious blows, and a separate stimulation module, which produces an aversive electric stimulation. The sensor module and stimulation module are mounted directly on a patient's body members, e.g., a sensor module can be mounted on a headband worn around the patient's head and the stimulation module can be mounted on an arm band worn around
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Electro-Optical Device for Monitoring Instantaneous Singlet Oxygen Concentration Produced During the Treatment of Cancer

A method and apparatus are disclosed for optically monitoring the concentration of singlet oxygen produced during photoradiation. A composite optical emission in the 1.27 micron frequency band is detected and electrically processed to separate a first component due to the decay of singlet oxygen from a second unwanted component due to the fluorescence of the photosensitizing dye. A pulsed excitation source is used to excite the photosensitizing dye and a time domain signal processor, such as a b
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Antifomitic Portfolio (736)

Abstract: Infection transmitted by contamination of objects in everyday use may be combated by periodic sterilization of such objects, as with ultraviolet sterilization lamps, or alternatively by covering them with cleanable or disposable protective barriers. Sterilization is impractical or insufficient for some objects and uses. In such cases a protective barrier may be desirable. The barrier approach is time honored and widespread, and includes current products covering items such as medical
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Sterilization Portfolio ()

Abstract: Sterilization by UV radiation is well known, working by attacking the DNA of microorganisms. UV below about 200 nm will also cause the generation of small amounts of ozone, an additional means of sterilization. However, most commercially available germicidal lamps operate on mercury vapor, which generates most of its light at 254 nm and does not create ozone. The subject technologies comprise five U.S. patents concerning UV sterilization with multiple international patents protecting
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Endothelium Preserving Microwave Treatment for Atherosclerosis (MSC-22724)

Abstract: The technology is for the non-surgical repair of diseased coronary arteries by interventional cardiologists during coronary catheterization. It is potentially safer than balloon angioplasty and other prior art. The device delivers millimeter / microwave energy by way of a catheter to precise locations of the coronary arteries and selectively targets and heats atherosclerotic lesions.
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Non-Invasive, In-Vivo Bubble Sizing Instrument (MSC-22980)

Abstract: This invention is a non-invasive, in-vivo instrument for detecting, classifying, and sizing gaseous emboli. Gaseous emboli are nitrogen bubbles that travel through the human circulation system and eventually obstruct blood flow. This technology is capable of distinguishing between gaseous and non-gaseous emboli.
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Body Fluids Monitor (MSC-22491)

Abstract: This invention relates to a process and apparatus for determining amounts of body fluids in a subject using bioelectrical response. Based on circuit components, the total volume of body water, the volume of extra-cellular water, the total blood volume and the total plasma volume of a subject may be calculated utilizing a sequence of measurements and processing steps.
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Whole Blood Staining Device (MSC-22614)

Abstract: The Whole Blood Staining Device is a hand-held, self-contained device which provides a means to stain white blood cells by using monoclonal antibodies conjugated to various fluorochromes, followed by lysing and fixing the cells using a diluted commercial reagent. It provides a means to store whole blood safely in a refrigerator for up to 72 hours before processing and analysis.
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Subversion of Bacterial Resistance by Low Solubility Antibiotic

BACKGROUND: Resistance to antibiotic treatment is increasingly common. Current strategies to overcome resistance include combination therapy with multiple classes of antibiotics, concurrent treatment with immunomodulating drugs or resistance inhibitors, or a mixture of these strategies. This invention describes how resistance can be overcome by using a delivery system based on fibrin, a naturally occurring protein involved in clot formation to provide a long-term release of effective antibiotic
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Monoclonal Antibody

Abstract (Set) A rat hybridoma producing a high-affinity IgG2a monoclonal antibody (B3B4) directed against the murine lymphocyte IgE receptor (FcR) was established by using purified FcR from FcR+ murine hybridoma B cells as immunogen. The monoclonal and polyclonal anti-FcR inhibited the binging of IgE to the murine lymphocyte FcR and were also used to isolate the FcR. B3B4 specifically recognized only the 49-Kd FcR or murine B lymphocyte as determined by immunoprecipitation and SDS-PAGE analysi
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Use of Retinoic Acid

Proliferation of retinal pigment epithelium following surgery or trauma is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR) agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is also a potent antagonist of AP1-dependent gene expression. Alternatively, the proliferation of retinal pigment epithelium is ameliorated with a therapeutic amount of an AP-1 antagonist, alone or in comb
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Recombinationally-targeted cloning in Saccharomyces cerevisiae artificial chromosomes

Homologous recombination techniques are used to produce yeast artificial chromosomes (YAC) containing foreign target DNA by utilizing at least three DNA segments which yield the vector. Preferred embodiments allow the production of viral DNA which is infectious.
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Microencapsulation of Living Cells By Biopolymers

The invention relates to living cells encapsulated in a membrane. The membrane is a complex formed by the cohesion of two polymer layers. An inner layer comprises a substrate biopolymer and an outer layer comprises a synthetic polyelectrolyte having an electrolytic charge opposite that of the substrate polymer. Droplets of a solution of substrate polymer containing a suspension of living cells can be added to a solution comprising the synthetic polyelectrolyte to form the encapsulates. The membr
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Biodegradable, timed release cytokine depots: a new approach in cancer vaccine design

Experimental studies have demonstrated that potent systemic immunity can be generated using tumor vaccines engineered by gene transfer to secrete cytokines. The physiologic principle behind these strategies involves the sustained release of high doses of cytokine local to the tumor. In some cases, this paracrine approach appears to enhance tumor antigen presentation and avoids systemic cytokine toxicity. The widespread clinical use of autologous cytokine gene transduced tumor vaccines may be lim
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A Method for Designing Optimum MRI Pulse Sequences for Imaging Oblique Planes

Straightforward method to calculate maximum gradient amplitudes for the functions of frequency encode, phase encode, and section select in oblique MRI. The calculated amplitude values depend on the angulation of the prescription, and on which of the three functions are simultaneously active. The derived expressions are optimal in most cases, and when not optimal still offer substantial improvement compared to calculations that do not incorporate angular information. Both matrix-based and geometr
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A Method of Operation for the Quadrupole Ion Trap in the Resonance Ejection Mode with Linear Dependence of the mlz Ratio of Ejected Ions upon the Trapping RF Voltage

A method for producing precise linear mass calibration and accurate mass measurements in the resonance ejection mode of an ion trap mass spectrometer using modulation of the endcap voltage amplitude proportional to the amplitude of the fundamental RF frequency.
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Algorithm for Predicting Protein Structure

Abstract (Set) Computer assisted method for predicting the 3-D structure of a protein fragment from its amino acid sequence utilizing folding hierarchy and localized energy functions. Description (Set) Proposed Use (Set) Accurate protein structure modeling is of use in the development of diagnostic and therapeutic protein fragments for use in rational drug design as well as analysis of biological function and activity.
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Method of and Apparatus for Sanitizing MRI Machines

Abstract (Set) Since the advent of MRI exam reimbursement cut-backs, the motivation for increased patient volumes is becoming commonplace. In addition, a wider range of patients with various medical ailments and medical histories including Leukemia, Sacoidosis, AIDS, Lymphoma, Cancer, Tuberculosis, Viral & Bacterial Menengitis, and Herpes Zoster. This combination of the infrequency of MRI bore cleaning couples with this blend of diseases could be significantly harmful to all persons exposed.
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Biomarkers for Pancreatic and Biliary Cancers

Abstract (Set) Pancreatic and biliary cancers are two of the most fatal among all human malignancies. Late presentation of the disease and lack of diagnostic markers are the major reasons for a dismal outcome of these cancers. The most widely used diagnostic marker for biliary and pancreatic cancers, CA 19-9, lacks specificity and sensitivity. Thus, there is an immediate need for more reliable diagnostic markers. We have identified proteins that are overexpressed in pancreatic and biliary cance
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Genome-wide Direct Transcription Measurement using Array-based Assay of Labeled Nascent RNA

Description (Set) JHU scientists have developed, optimized and validated an innovative approach for study of nascent RNA transcription. Post-transcriptional regulation of gene expression constitutes critical and wide-spread mechanisms. However, only ongoing transcription accurately reflects momentary regulatory events of transcriptional regulatory mechanisms. Ongoing transcription can be measured and distinguished from mRNA sequence turnover using Nuclear run-on (NRO) assays. Traditional NRO as
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A Method for Monitoring Protein S-Nitrosylation

S-nitrosylation is the addition of a nitric oxide group to a cysteine group in a protein sequence to form an S-nitrosothiol derivative. JHU scientists developed a method in which a test sample comprising at least one protein substrate is treated with an alkylthiolating agent to block free thiol groups on the substrate. Nitrosothiol bonds on the protein substrate are reduced to form free thiol groups. The free thiol groups on the protein are reacted with a tagged, activated mixed disulfide which
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Anti-HIF-1B Antibodies

Polyclonal antibodies were raised in rabbits and monoclonal antibodies were raised in mice that recognize hypoxia-inducible factor-1? Description (Set) Proposed Use (Set) These antibodies can be used for biomedical research to detect expression of HIF-1�in immunoblot, immunoprecipitation, and immunohistochemical assays
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Anti Qa-1 Monoclonal Antibodies

Dr. Soloski's laboratory has been interested for a number of years in the function of non-polymorphic class Ib molecules. For the last few years we have focused on the murine non-polymorphic molecule Qa-1b encoded by the gene H2-T23. The "b" superscript represents the particular allele of Qa-1 recognized and Qa-1b is the allele expressed in common inbred strains such as Balb/c and C57BL. This molecule can present peptides to alloreactive CTLs, may serve as novel antigen presentation for microbia
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Coordinate independent, consistent and high level dual-gene transgenesis from a single lentiviral vector

Expression of multiple genes within the same target cells is required for certain gene delivery and therapeutic applications. In spite of such need, reaching independent, coordinate and high level dual-gene expression is still a challenging task. Non -uniform transfer, promoter interference, and poor expression levels are only some of the problems associated with existing approaches to dual-gene transfer. Chemical and biological engineers at the University at Buffalo have developed a new approac
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Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell source to facilitate cell-based tissue engineering. Chemical and biological engineers at the University at Buffalo have isolated a population of multipotent stem cells from the human hair follicle. These c
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Coordinate independent, consistent and high level dual-gene transgenesis from a single lentiviral vector

Expression of multiple genes within the same target cells is required for certain gene delivery and therapeutic applications. In spite of such need, reaching independent, coordinate and high level dual-gene expression is still a challenging task. Non -uniform transfer, promoter interference, and poor expression levels are only some of the problems associated with existing approaches to dual-gene transfer. Chemical and biological engineers at the University at Buffalo have developed a new approac
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Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device has been designed to overcome this deployment challenge. The device allows for precise longitudinal and azimuthal positioning. Further, the design enables easy navigation of the tortuous vessels o f
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Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering application: tissue engineered vasculature (TEV). TEVs developed using these cells demonstrate all the functional characteristics of normal vasculature,including but not limited to mechanical strength and
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Resorbable Laminated Repair Membrane for Accelerated and Sustained Wound Repair

Tracheal epithelial cells were cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. Technologies no. 5546 and 5558 studied how bio-degradable polymers and degradation proc esses could be used in replanting tracheal epithelial tissue. Technology no. 5764 showed choreographed releases of two or more proteins from degradable biopolymers integrating epithelial cells post-implantation. This invention combines all of the ab
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Choreographed, Active Protein Delivery from Biodegradable Devices

Tracheal epithelial cells were earlier cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. Technologies no. 5546 and 5558 studied how bio-degradable polymers and degradat ion processes could be used in replanting tracheal epithelial tissue. To implant and successfully integrate epithelial cells within tracheal lumen, the nature and delivery kinetics of participant proteins from degradable biopolymers need to be under
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High Throughput Spectro Fluorimetric Screen for Drug Binding to Human Serum Proteins

This invention describes an improved method for determining the binding properties of drugs to human serum (human serum albumin (HAS) and alpha-1 acid glycoprotein (AAG). It uses spectrofluorimetry and works by measuring the effect of the drug on the fluorescence spectra of the human serum. The result is that each bound drug has a different "quenching curve" on the intrinsic fluorescence of the human serum, a phenomenon useful for screening combinatorial libraries. The invention offers a ntag
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Novel breakable crosslinkers and pH-responsive star-shaped and gel polymers

This invention describes a method for the preparation of novel crosslinkers and their application to star-shaped or branched polymers and polymer gels. The polymers can be easily changed to linear co-polymers and exhibit different properties in acid ic or basic media. These polymers and polymer gels may be useful for controlled drug delivery and release. The crosslinkers are bifunctional monomers such as ethylene glycol di (1-methcryloyloxy) ethyl ether and ethylene glycol (1-acryloyloxy) et
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Synthesis and Processing of degradable Fluorocarbon End-Capped Polymers and their uses as Biomaterials

Tracheal epithelial cells were earlier cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. This technology describes the synthesis of bio-degradable polymers and study of degradation processes to replant tracheal epithelial tissue in real and for use in drug delivery systems. This new series of surface modified biodegradable polyester polymers allow a small presence of a fluorocarbon surface modifier whose chemistry
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Method of Testing the Degradation of Polymeric Biomaterials

TA model that mimics epithelialized tracheal luminal surface as it exists was earlier described in technology no. 5413. Using the said model, this invention studies the reaction kinetics of bio-degradable polymers (Poly (Glycolic) Acid) using “Time o f Flight (ToF) Secondary Ion Mass (SIMS) spectrometry”. The values are: 1) Static compositions as well as reaction products on the surfaces of materials during the degradation process are detected dynamically. 2) Reaction rates and other kine
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Composite Culture on in Vitro Model (3-dimensional) of Tracheal Lumen

Tracheal epithelial cells are currently not replenishable, if lost through chemical (drug) action, intubations or other means. This invention is the first model that mimics the tracheal lumenal surface as it exists and can be used as a research tool to develop implantable tissue in future. Possible studies using this are: airway mucosal surface repair, interactions of synthetic polymers with chondrocytes and epithelial cells, roles of compounds like cytokines, transforming growth factors (TGF),
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Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The protrusion of loop 5 from the P2 sequence allows for proper presentation of the fused antigen, and hence an enhanced immune response. The fusion protein may be expressed on the surface of the host cell, such as in H.
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Resorbable Laminated Repair Membrane for Accelerated and Sustained Wound Repair

Tracheal epithelial cells were cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. Technologies no. 5546 and 5558 studied how bio-degradable polymers and degradation proc esses could be used in replanting tracheal epithelial tissue. Technology no. 5764 showed choreographed releases of two or more proteins from degradable biopolymers integrating epithelial cells post-implantation. This invention combines all of the ab
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Novel breakable crosslinkers and pH-responsive star-shaped and gel polymers

This invention describes a method for the preparation of novel crosslinkers and their application to star-shaped or branched polymers and polymer gels. The polymers can be easily changed to linear co-polymers and exhibit different properties in acid ic or basic media. These polymers and polymer gels may be useful for controlled drug delivery and release. The crosslinkers are bifunctional monomers such as ethylene glycol di (1-methcryloyloxy) ethyl ether and ethylene glycol (1-acryloyloxy) et
...

Synthesis and Processing of degradable Fluorocarbon End-Capped Polymers and their uses as Biomaterials

Tracheal epithelial cells were earlier cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. This technology describes the synthesis of bio-degradable polymers and study of degradation processes to replant tracheal epithelial tissue in real and for use in drug delivery systems. This new series of surface modified biodegradable polyester polymers allow a small presence of a fluorocarbon surface modifier whose chemistry
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Method of Testing the Degradation of Polymeric Biomaterials

TA model that mimics epithelialized tracheal luminal surface as it exists was earlier described in technology no. 5413. Using the said model, this invention studies the reaction kinetics of bio-degradable polymers (Poly (Glycolic) Acid) using “Time o f Flight (ToF) Secondary Ion Mass (SIMS) spectrometry”. The values are: 1) Static compositions as well as reaction products on the surfaces of materials during the degradation process are detected dynamically. 2) Reaction rates and other kine
...

Composite Culture on in Vitro Model (3-dimensional) of Tracheal Lumen

Tracheal epithelial cells are currently not replenishable, if lost through chemical (drug) action, intubations or other means. This invention is the first model that mimics the tracheal lumenal surface as it exists and can be used as a research tool to develop implantable tissue in future. Possible studies using this are: airway mucosal surface repair, interactions of synthetic polymers with chondrocytes and epithelial cells, roles of compounds like cytokines, transforming growth factors (TGF),
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Composite Culture on in Vitro Model (3-dimensional) of Tracheal Lumen

Tracheal epithelial cells are currently not replenishable, if lost through chemical (drug) action, intubations or other means. This invention is the first model that mimics the tracheal lumenal surface as it exists and can be used as a research tool to develop implantable tissue in future. Possible studies using this are: airway mucosal surface repair, interactions of synthetic polymers with chondrocytes and epithelial cells, roles of compounds like cytokines, transforming growth factors (TGF),
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Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device has been designed to overcome this deployment challenge. The device allows for precise longitudinal and azimuthal positioning. Further, the design enables easy navigation of the tortuous vessels o f
...

Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell source to facilitate cell-based tissue engineering. Chemical and biological engineers at the University at Buffalo have isolated a population of multipotent stem cells from the human hair follicle. These c
...

Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering application: tissue engineered vasculature (TEV). TEVs developed using these cells demonstrate all the functional characteristics of normal vasculature,including but not limited to mechanical strength and
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Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a convenient label of its own, such as stem cells, and it costs additional time and money to develop and append appropriate and effective labels, such as antibody tags and magnetic beads. Sometimes, all
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Cell line expressing functional alpha1D-adrenergic receptors

Introduction The alpha1D-adrenergic receptor (AR) is a major regulator of cardiovascular and central nervous system function. Targeting AR is thus of major interest to the pharmaceutical industry for developing new medicines to treat hypertension and neurological disease. However, it has been impossible to screen for potential new α1D–AR ligands because of the inability to obtain sufficient functional expression in cells. Technology description To overcome the lack of stable in vitro express
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Receptor-Ligand Assay for orphan tyrosine kinase receptors

Summary Transmembrane receptors are proteins which are localized in the plasma membrane of eukaryotic cells. They mediate molecular signaling functions by binding specifically with an external signaling molecule (the ligand) which activates the receptor. Receptor activation in turn leads to an intracellular catalytic function mediated by an intracellular domain of the transmembrane receptor, while the ligand remains outside the cell. Researchers have found it relatively straightforward to iso
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Methods for Improved Viability of Cells at Low Temperature

Summary Discovery of the linkage between the expression of Trigger Factor, a protein of previously-unknown function, and resistance of living cells to cold-shock has led to development of methods that enable prokaryotic and eukaryotic cells to remain viable at temperatures at- or below which they would not normally proliferate or survive. Controlled expression of Trigger Factor enables cells to maintain essential activities at low, typically lethal, temperatures; of particular use are Trigger Fa
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Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a convenient label of its own, such as stem cells, and it costs additional time and money to develop and append appropriate and effective labels, such as antibody tags and magnetic beads. Sometimes, all
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Microfluidic Devices with Tunable Microtopography

Introduction Microfluidic devices are critical components of many biomedical and bioanalytical instruments and allow for probing chemical and physical phenomena at the micron scale. Most current microfluidic devices, however, have the inherent functional limitation that the cross-sectional channel geometry, which determines the fluid flow patterns, is essentially constant at any given point in the channel. Hence its functionality is fixed or can only be changed by changing the flow rate. Technol
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Cyclic Nucleotide Phosphodiesterase Family 10 / PDE10

Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 PDE genes that are categorized into 11 families. Selective inhibitors against individual PDE families have been developed as therapeutics for treatment of various human diseases. PDE10 shows a dual activity on hydrolysis of both cAMP and cGMP and is highly expressed in brain striatum. Technology des
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Screening for Drugs Targeting tRNA Synthetase

Introduction Dr Jonathan Gallant’s laboratory has developed biomaterials that identify specific tRNA deficiencies within cells. These biomaterials can be used to screen for compounds which inhibit tRNA synthetases, such as certain classes of antibiotics, as well as to ensure efficient protein expression in recombinant systems. Technology description This technology involves a DNA sequence inserted into a plasmid-borne reporter gene causing the gene’s expression to vary with availability of a
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Automated laboratory system and analytical module

Our invention: Fast Lab Technology is a cornerstone in preventive and lower cost health care of USA Government program: http://www.codebuildingblocks.com/Michael/FastSpin Our technology intends to decrease time and cost of routine and esoteric tests and comprises some new engineering methods and devices. Project fits with existent testing technology and does not require changing analyzing methods. Reduction in medical errors will reduce health care cost by several $Billions per year and
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Thermal Responsive Iron Oxide Magnetic Nanoparticles

Introduction Stimuli-responsive materials and molecules have numerous possible applications in the biomedical/pharmaceutical field, as well as in biotechnology and the related industries. Smart conjugates, smart surfaces, smart polymeric micelles and smart hydrogels have all been studied for a variety of diagnostics, separations, cell culture, drug delivery, and bioprocess applications. Despite the development of magnetic nanoparticle technologies for diagnostic and imaging applications, there e
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Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cells composed of a polymer:fullerene composite layer sandwiched between a transparent metal-oxide anode and a metallic cathode are one of the most successful types of polymer solar cells. However, the p
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Method of enhancing expression of recombinant proteins

Introduction Large scale production of industrially and medically important proteins is achieved using “expression systems”, whereby a gene encoding the protein of choice is introduced into a cell (e.g. yeast or bacterial) that is optimized for high-yield expression. Many proteins are poorly produced in bacterial cells for reasons that are usually attributed to "codon usage". Most mammalian proteins are encoded by genes that use "AT-rich" codons whereas most proteins in E. coli use codons t
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Method for Generating Human Retinal Neurons and Photoreceptors from Embryonic Stem Cells

Introduction The degeneration of neurons and photoreceptors in the retina occur in a number of disorders for which there are currently few therapies, including retinitis pigmentosa, age-related macular degeneration, and glaucoma. Although retinal regeneration is robust in lower vertebrates, regeneration does not occur in the adult mammalian retina. The repair of the retina with replacement cells derived from human embryonic stem cells could thus provide the basis for new approaches for treating
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Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse host response. Ideally, a new bladder could simply be formed from the patient’s own cells. Technology Description Professor Ratner at the University of Washington has developed a technique to creat
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Programmable Generation and Transport of Droplets on Microscale Generation and Transport of Droplets on Microscale

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively perform the many processes that may be required of a microfluidic system, various tools are required, such as pumps, valves, mixers, and ratchets. In particular, the development of ratchets and other
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Three-dimensional (3-D) Thin-Film Microbattery

The Invention Alasan is a novel bioemulsifier produced by the microorganism Acinetobacter radioresistens KA53. It is a high molecular weight complex composed of an anionic polysaccharide containing a significant % of covalently bound alanine and four proteins. The Need Emulsifiers are used widely in industry, in medical and cosmetic products and in food systems. Most commercially available emulsifiers are produced by chemical syntheses. The cosmetics and pharmaceutical industries are cont
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Novel Antimicrobial Peptides

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY The core technology stems from research into a class of human proteins involved in innate immunity, whose role in fighting infection had not previously been identified. Specific regions of these pro
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Exciplex™ a Highly Sensitive Nucleic Acid Fluorescent Detection System

BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The small Stokes shift (difference between excitation and emission wavelengths) often requires optical filters to be used that further reduce sensitivity. Several detection techniques (Molecular Beacons, Sniper etc) also require the use of long oligonucleotide sequences whose design complexity can limit the
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3-D Self-assembled Peptide Hydrogels

BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extracellular matrix interactions. Self-assembling peptides, with the various properties of amino acids (biological compatibility; bonded structure), are very powerful building blocks for the fabrication of self-assembling scaffolds. Dr. Rein Ulijn of the School of Materials at the University of Manches
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Biodrug Delivery Mechanism Via Yeast Encapsulation

BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically engineered yeast strain, able to express recombinant protein drugs / vaccines and incorporating a genetic switch to trigger cell lysis in response to specific conditions has been developed. The key concept is the passage of intact yeast cells through the stomach, and their subsequent lysis in the i
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Shp-2 Tyrosine Phosphatase and Embryonic Stem Cell Differentiation

Shp-2 Tyrosine Phosphatase and Embryonic Stem Cell Differentiation
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Apparatus and Method for Optical Detection of Seizures and Cerebral Edema

Background: Currently seizures are detected from deep brain structures with the use of electroencephalography (EEG). EEG recordings are made through electrodes placed on the scalp, on the brain surface, or inserted deep in the brain. EEG works through amplification of minute voltage potentials generated in brain tissue. As such it has inherently low signal to noise ratio and requires controlled conditions for optimal signal detection. A fiber based optical system has a higher signal to noise ra
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Photo-electric Device and Method for High Throughput Activation, Guidance and Poration of Targeted Cells with High Spatial Resolution

Background: In biomedical research, controlled modulation of physiological functions of various excitable cells such as skeletal, cardiac and neuronal cells is important. The information derived from activation of these excitable cells under different chemical environments can lead to the evaluation of therapeutic drug efficacy. Further, there is a need for controlled poration of exogenous materials/genes into living cells. Various electrical, chemical and optical methods are recently being pur
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Fiber Optic Probe and Method for Optical Trapping, Ablation, Excitation and Detection of Microscopic Objects

Background: Manipulation of microscopic objects by laser methods has been used since the 1970s. Both laser tweezers (used to hold microscopic objects in place) and optical scissors (used to conduct delicate surgery on the object in question) allow the scientists and engineers to perform minimally invasive manipulation of micro/nano objects which include single molecule, living cells and their organelles. Further, changing properties of light beam (e.g. circular polarization), the optical tweeze
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Method and Apparatus for Performing Qualitative and Quantitative Analysis of Wounds Using Spatially Structured Illumination

Background: Use of instruments to assess etiology and status of chronic wounds is still in an embryonic state. Clinicians rely primarily on clinical features such as wound size, location, depth, and infection in order to make treatment decisions regarding the patient care. Several array of medical devices under investigation for wound care include Doppler ultrasound, Doppler perfusion imaging, transcutaneous measurement of tissue oxygen and near-infrared spectroscopy. One common drawback to the
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Novel Antenna Angiography Catheter

Background: Cardiac catheterization is typically performed with stiff-tipped catheters. In order to engage a blood vessel orifice, the stiff tip must be positioned at a precise location, and in the correct orientation. During the relatively extensive manipulation sometimes required for target vessel cannulation, the stiff catheter may cause vessel trauma to the wall of the blood vessel or the cardiac chamber. In addition, the opening of a target blood vessel may be difficult to locate with the
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Fast Lysis Cell Traps

Background: Chemical cytometry involves the use of high-sensitivity analytical tools, such as mass spectrometry, electrochemistry and capillary or microfluidic separation methods to characterize single cells. In order to accomplish this analysis, it is desirable to selectively apply cells to predetermined regions of a substrate, also know as cell patterning. Chemical cytometry employing an electrophoretic separation has been used to measure a wide range of cellular properties; for example, quan
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A Device and Method to Remove Excess Glucose in the Small intestine for Prevention and Treatment of Type 2 Diabetes and Obesity

Background: Type 2 Diabetes, also known as non-insulin dependent diabetes mellitus (NIDDM) or adult-onset diabetes is the most common form of diabetes affecting 90-95% of the 21 million Americans diagnosed with the disease. While traditionally diagnosed in adults over the age of 40, it is increasingly seen in children and adolescents, an increase thought to be linked to the rising rates of obesity in this age group. Unlike those with Type 1 Diabetes, people with Type 2 diabetes produce insulin
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Magnetic Resonance Compatible Electric Motor

Background: Standard electrical motors when used in magnetic resonance (MR) instrumentation may interfere with the functionality of the MR imaging. These interferences from the motor distort the resulting MR images. Developing a motor that operates in high magnetic fields used in MR imaging and MR based intervention procedures without distorting the resulting images is desirable. Technology: University of California, Irvine researchers have developed a high torque and novel electric motor th
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Continuous Reciprocal Flow in a Microfluidic Device for Efficient Mixing

Background: In certain microfluidic devices, continuous mixing of fluids is desirable depending on the application. For example, in the conventional or passive hybridization method, a DNA microarray is placed in solution where the immobilized single stranded DNA probes hybridize with complementary target cDNAs in the surrounding stagnant fluid sample. Since DNA hybridization is a bimolecular reaction, it relies solely on the diffusion of target DNA molecules to the capture probes, which is a
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Nanosecond Laser Cell Lysis in Microfluidic Devices

Background: To date, cell lysis in microfluidic devices for analytical purposes has been achieved using chemical, electrical, and optical means. Chemical cell lysis occurs on time scales of several to tens of seconds and is adequate for analytes whose chemical states change on such time scales. However many biochemical processes within cells occur on sub-second to second time scales including the production of second messenger and signaling lipids or the activation of kinases and phosphatases.
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Safer Endotracheal Tube Cuff Pressure Regulation System

Background: The means to regulate endotracheal tube cuff pressure have been proposed in order to decrease the incidence of post-intubation complications caused by cuffed endotracheal tube. The regulation of endotracheal tube cuff pressure in prior art is achieved via a complex external pressure regulating device, which is characterized by inflating the cuff to the desired maximum pressure level during inspiration and deflating the cuff to the desired minimum pressure level during expiration.
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Construction of Single Molecule Electronic Devices, with Applications to Biosensing

Background: "Molecular Electronics" (ME) generally refers to a class of novel electronic devices in which the electronic response and function are entirely controlled by single molecules. In principle, a wide range of devices can result from the incorporation of different types of molecules (e.g. molecules that switch, store charge, absorb light, or otherwise participate in reactions). Covalently linking a single molecule of interest between two electrical conductors enables the electrical inte
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Micromachined Passive Programmable Drug Delivery Systems

Background: The ability to deliver drugs locally to the site of need and over a prolonged period of time is important as a therapeutic method for many ailments and diseases. Many drugs are more effective if delivered at a specific site since they can be delivered in concentrated dosages at the point of interest, while maintaining an overall low dosage within the total body. Some drugs require delivery in places that are inconvenient for injection. For example, the highly invasive nature of the
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Soft Tissue Dissector

Background: Laparoscopic surgery has become part of the standard armamentarium for many urologic surgeons. Currently a wide variety of instruments are used to facilitate dissection during laparoscopic surgery. Each time a different instrument is used, it requires removal and reinsertion. Over the course of a few hours, this can amount to a significant portion of time. One of the commonly used instruments is a cotton tipped dissector (i.e. Kitner) that is frequently used for blunt dissection. Th
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Non-scattering Oxygen Carrying Media for Intravascular Optical Coherence Tomography Imaging

Background: If blood is replaced locally in the vascular system by injection of saline solutions, OCT images can be obtained for brief periods of time, but lack of oxygen is deleterious to the tissues, and ischemia and damage will result, compromising patient health, as well as the OCT images obtained. There is a need for a replacement media which could deliver/make available oxygen to tissues while they are imaged by OCT. Technology: University of CA researchers have developed a clear media
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An Integrated Microfluidic Platform with Lateral Dielectrophoresis (DEP) Based Cell/Particle Separation

Background: Most of the current techniques used for Dielectrophoresis separation use planar electrodes which sit at the bottom of the channel. With this design the electric field decreases dramatically as the height increases. Correspondingly, the gradient of the electric filed which is denoted as the direction of the DEP force will be along the height of the channel. This phenomena is implemented in field flow fraction (FFF) DEP to balance the gravity of the cells so that different cells will
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Portable Load Monitoring Device for a Patient"s Foot

Background: Subsequent to a variety of medical procedures including, but not limited to knee arthroplasties, hip arthroplasties, and fracture repairs, post-operative weight-bearing on the affected leg must be limited to facilitate proper healing and avoid exacerbation of injury. However, some degree of axial load is often tolerated to enable appropriate rehabilitation to take place. A maximally allowable weight load is usually determined by the appropriate surgeon or physician, and this is typi
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A Method and Apparatus to Inactivate Stem Cell Nuclei

Background: Stem cells may hold the key to future cures for many diseases. These are embryonic cells that are thought to have the potential to develop in any kind of tissue: liver, kidney, brain, etc. There is great scientific, medical, and economic interest in any technology that can facilitate the therapeutic use of stem cells. The use of stem cells in scientific research has initiated a political debate regarding the ethics of deriving stem cells from human embryos. Thus any technology that
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Generation of Stable Concentration Gradients in 2D and 3D Environments Using a Microfluidic Ladder Chamber

Background: In the chemical, biomedical, and pharmaceutical industries, it has become increasingly desirable to perform large numbers of chemical operations in a highly parallel fashion. For example, cell culture methods are a commonly used research techniques that allows the systematic manipulation of a growth condition of cells. In cell culture the culture media and substrate can be varied under controlled conditions. With well known culturing techniques the entire cell is exposed to the same
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A Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same

Background: In many neurodegenerative diseases and in spinal cord injury, axons and synapses are damaged; a cell culture model is useful for investigation into these areas of research. In typical cell culture it is difficult to distinguish axon from dendrite, and fairly impossible to simulate microenvironments encountered along axons, dendrites or synapses. In a Petri dish for example there is no way to prevent cells from combining and hence it is difficult and in some cases impossible for even
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Use of Optical Coherence Tomography (OCT) for Use of Comprehensive Intra-oral Diagnosis

Background: In dentistry there exists a pressing need for novel diagnostic modalities. A strong consensus for reducing patient exposure to ionizing radiation is countered by the absence of other non-invasive diagnostic and monitoring tools. Diagnostic options for soft tissue pathologies are also limited and inadequate. Current technologies for intra-oral diagnostics are invasive and include radiographs, clinical examination, intra-oral staining techniques and biopsy. Disadvantages to these tech
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Formulation of Monodisperse Contrast Agents in Microfluidic Systems for Ultrasonic Imaging

Background: Ultrasound imaging may be used to produce a 2D image of the body's internal structures. However, since blood is much less (1000x less) echogenic than tissue, small vessels, blood pool volume and blood flow all are difficult, if not impossible, to image using traditional ultrasound techniques. Researchers discovered, however, that by introducing micro-bubbles (USCAs) into the circulation many of the limitations surrounding blood imaging could be overcome. Of the recent developments i
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Rapid Multiplex Gene and mRNA Detection in Picoliter Droplets by Molecular Beacons

Background: Breast cancer is a world wide public health concern and the estimated death toll in the U.S. in 2001 was 20,000 and it also ranked first as the cause of cancer death for women between the ages of 20 to 59. People carrying a mutation in the BRCA1and BRCA2 genes are prone to breast cancer and ovarian cancer. The conventional DNA detection method which involves a heterogeneous solid-liquid hybridization process requires probe immobilization. Stringent rinsing to remove specific DNA bon
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Microfluidic Production of Monodispersed Submicron EmulsionsThrough Filtration and Sorting of Satellite Drops

Background: In the past decade, droplets have been intensively used by the industries as an agent for drug preparations, for plastic polymerizations, and chemical processing. Recent advancements in microfluidic droplet technology has enabled the precise sampling and processing of small volumes of fluids (picoliter to femtoliter) by the controlled viscous shearing in microchannels. Microfluidic technologies has transformed droplets to be used as liquid reaction vessels for screening protein crys
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Wall-Less Microfluidics with On-Site Magnetohydrodynamic (MHD) Pumps for Continuous Flow Control

Background: A disadvantage of closed microfluidic channels are that they are made from different materials. Also, most of the microchannels are fabricated from lithography techniques which require the utilization of cleanroom environments, increasing the fabrication costs. Another disadvantage of the closed microchannel is that, after several rounds of fluid flow through, the channels become contaminated and difficult to clean. Technology: Researchers at the University of California have dev
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Fiber optic bundle based optical coherence tomography

Background: Optical coherence tomography (OCT) has been used for high resolution optical imaging in many areas of medicine, especially ophthalmology. "Conventional wisdom" was that OCT could not be done through flexible fiber bundles. Indeed, the use of flexible fiberoptic bundles to deliver OCT directly to a tissue sample has not been previously achieved. Technology: University of California researchers have developed a method and apparatus for performing fiber-optic bundle based OCT. Altho
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Rapid Bio-Molecules Detection by Adjacent Impedance Probing (AIP) Techniques

Background: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, photoproteins, etc.) and the binding of these large molecules to their complementary molecular structures (e.g., complimentary oligo-nucleotide hybridization and ligand binding protein or antibody binding). While spectroscopic methods afford the necessary sensitivity for most of these measurements, t
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Method of Fabrication of Self-enclosed Microchannels and/or Chambers with or Without Integrated Interconnects and Electrodes

Background: Conventional methods that create fluidic channels using photopolymers create channels and chambers by-coating, patterning, and developing each layer sequentially. These conventional methods of fabricating microchannels also involve using molds or patterning channels onto a flat substrate. In the latter method, the flat substrate acts as the bottom support for the microchannel or chamber. Microneedles have been fabricated using a variety of methods including molding and micromachinin
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Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood Vessels

Background: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means of treatment care for PWS and achieves effect by selectively targeting tissue vasculature. However, few PWS patients (< 20%) achieve complete blanching of their lesion and multiple treatments (5 -30 or more) are generally required. One primary factor limiting vascular lesion blanching for many patien
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New Protein Resistant and Biodegradable Biopolymer

Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as the commonly used poly(ethylene glycol) (PEG) have been used in a number of applications such as prostheses, contact lenses, implanted devices, microfluidic systems, drug delivery, and substrates for assays. However PEG has two major limitations. First PEG can only be functionalized at the chain end
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Top-Gate Carbon Nanotube Field Effect Transistor

Background: A carbon nanotube (CNT) is a one-dimensional molecular wire which is believed to have many potential applications in upgrading the density and performance of electronic information systems. Technology: This invention solves six potential problems with incorporating CNT's into next generation electronics: controlled growth (location, orientation, and diameter) of the CNT; low contact resistance between the CNT and electrode; local capacitive coupling between the CNT and gate; limi
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A New Burr Design

Background: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty has significantly restricted the ability to do effective endoscopic surgery around the spine. Shielding of the cutting tool makes the tool too large to work in the limited space given, and makes the tool too dangerous and inefficient. Using any of the current cutting tools without complete visualiza
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New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle Circuit

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, VO2 and VCO2 are typically NOT measured during anesthesia because collection of mixed expired gas is nearly impossible in the circle circuit. Instead, an inline bypass mixing chamber, or bymixer measures mixed V
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Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During Anesthesia

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, no accurate calibrating measurement of VO2 is available during anesthesia. Technology: University of California, Irvine researchers have developed a novel, closed circle, ventilating circuit which can be a ca
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A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory Prostheses

Background: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids and cochlear implants to ameliorate hearing loss have their disadvantages. Some of these include high power consumption and long processing time associated with a large number of channels which increases its cost and size and limits its utility. Technology: University of California, Irvine resea
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Nanowires as Fast Chemical Sensors

Background: Recent years have witnessed a significant interest in biological applications of novel solid-state nanomaterials. The unique physical properties of molecular or nanoscale solids when utilized in conjunction with the biomolecular recognition capabilities could lead to miniaturization of biological electronics and optical devices including sensors. Technology: University researchers have developed a method of measuring the dynamic impedance of a nanowire such as, but not limited to
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Smart Probe with Station for Real Time, Non-Invasive Metrology of Microfluidic Chips

A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locations within a bio-fluidic chip. This station would allow for automated, high-throughput testing and evaluation of microfluidic chips during and after manufacturing.
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Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the creation of macromolecular binding and catalytic sites and as binding sites for the separation or resolution of optical isomers or enantiomers. In many of the methods previously known for preparation of MlPs, the monomers used have not been soluble in water or aqueous media at the concentrations ut
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Prevention of Ice Formation on Tissue Surfaces Caused By Cooling During Laser Surgery

Background: A complication of using a cryogen gas to provide cooling during laser irradiation of biological tissues is the formation of ice crystals. This formation of ice on the tissue surface causes two major problems: 1) it decreases the incident light dosage due to optical scattering by the cryogen-ice layer, and 2) it decreases the cooling effectiveness of the cryogen because cryogen becomes trapped in the ice and cannot easily evaporate. Technology: Researchers at the University of Cal
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Genes Encoding Telomere-Associated Proteins

APPLICATIONS OF TECHNOLOGY: - Molecular biology research - Medical research ABSTRACT: Telomeres are believed to be critical regulators of the genome, and telomere stability important for preventing cancer and ageing. Regulation of telomere length is believed to be controlled by multiple telomere-associated proteins. Using a previously cloned human telomere binding protein, Berkeley Lab researchers Sahn-ho Kim and Judith Campisi cloned two novel human telomere-associated proteins, TANK-2 and
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Full Karyotype Analysis for Increasing Pregnancy Rates per IVF Cycle

APPLICATIONS OF TECHNOLOGY: - Screening all 24 chromosomes for numeric chromosome abnormalities during Preimplantation Genetic Diagnosis - Diagnosing disease states requiring cytogenetic analysis - Monitoring the effects of accidental or occupational exposure to environmental hazards ADVANTAGES: - Allows full karyotype analysis of cells in interphase - Highly adaptable and flexible assay design - Works with a variety of cell types EXPECTED OUTCOMES: - Fewer spontaneous abortions - Fewe
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Diagnostic MRI Skin Map Database

IB-2390 APPLICATIONS OF TECHNOLOGY: Using MRI data to develop a database that systematically characterizes skin properties Developing a skin map for a patient and comparing it to the database to determine the best treatment Using a patient’s MRI skin map data to determine the settings of skin treatment devices (e.g., a laser) ADVANTAGES: Enables skin care professionals to better diagnose and characterize skin and determine the optimal treatment options Quantifies MRI skin-d
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Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and Biopsy

APPLICATIONS OF TECHNOLOGY: Detects prostate cancer using accurately co-registered positron emission tomography (PET) and transrectal ultrasound (TRUS) images Guides prostate biopsy sampling Monitors response to treatment and detects local recurrence ADVANTAGES: Provides high-resolution anatomical detail in the prostate region through TRUS images, allowing tumors detected by PET to be localized precisely Compact and open prostate-optimized PET design allows convenient access for
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Method of Production of RNA Polymerase Protein

Abstract The invention relates to the production of protein 2a that can copy, in vitro, any RNA. The invention provides a method for obtaining a stable RNA polymerase enzyme by expressing protein 2a in cells, pelleting the cells expressing protein 2a, macerating the cells expressing protein 2a to obtain a cell lysate, and filtering the cell lysate through an affinity resin. Potential commercial uses and users: In molecular biology during lab work. In vivo. Advantages: This is the first
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Counter-Current Fluid-Fluid Flows Mixer (C2F3M)

The process of mixing fluids, or fluids and particulates, is critical in biology, chemistry, medicine, and engineering and in numerous applications involving the synthesis of pharmaceuticals, flows through biomedical devices, the fabrication of materials, the food industry, and contamination of the environment. Mixing processes may occur in equipment spanning many length scales ranging from industrial macrosystems such as stirred tank rectors and separation columns, to microsystems such as micro
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Novel High Volume Process for the Production of Silver Nanoparticles with Controlled Shape and Dimension (SilverFluidicsTM)

New Market Opportunity: Silver nanoparticles have applications in a wide number of fields across the electronics, physics, chemistry and biomedical fields. The optical absorption and fluorescence characteristics of the silver nanoparticles are critical to their functionality in all applications. The control of the shape and dimension of the silver nanoparticles, within a tight range, and the ability to programmably change the target size and shape of the silver nanoparticles, within a chemical
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