Biomedical Patents for Sale or License

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Enzymes for Inhibiting Growth of Biofilms and Degrading Same

Enzymes for inhibiting growth of biofilms and degrading biofilms. The enzymes comprise glycosyl hydrolases capable of degrading biofilms. The enzymes are formulated in compositions with and without antimicrobial agents. The enzymes with and without the antimicrobial agents are delivered to biofilms ...
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Osteotome System

A plurality of osteotomes that are linked together via a recess and a matching projection such that the osteotomes remain linked when used to manipulate bone....
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Therapeutic Nucleic Acid-3'–Conjugates

Methods are described for improvement of the serum half life of therapeutic nucleic acids by 3' conjugation to useful target proteins, or other large molecules with useful function. In one embodiment, a 3' A, C or G overhang is added to ds-DNA and the primary amines conjugated using biocompatible bi...
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Methods of Producing Intrachain Fluorophore-Quencher FRET-Aptamers and Assays

The present invention describes methods for the production and use of single chain (single-stranded) fluorescence resonance energy transfer ("FRET") DNA or RNA aptamers containing fluorophores (F) and quenchers (Q) at various loci within their structures, such that when its specific matching analyte...
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Methods and compositions of DNA ligands (aptamers) for arthropod-borne pathogen detection and prophylaxis or therapy

Specific DNA ligand sequences (aptamers) for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two- and three-dimesional linked sequences can function in varying assay and sensor formats with varying de...
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Methods and compositions of nucleic acid ligands (aptamers) for detection of clinical analytes related to human health

Specific DNA sequences (aptamers) for binding various clinically relevant analytes from the human body are described. Each of these sequences or their linear, two- and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linakge of th...
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Fingertip Force, Location, and Orientation Sensor

An integrated system for studying human grasping techniques includes a fingerprint sensor and a force sensor for simultaneously measuring the contact position and orientation of a fingertip together with the contact force and torque exerted by the fingertip during a grasp. The system uses the finger...
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Volume Exclusion Agent to Enhance Formation of Extracellular Matrix

A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition involves procollagen processing...
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Salmonella-based anti-cancer vaccine

We offer a technology of vaccine-based cancer therapy developed at the Jagiellonian University (Krakow, Poland). The immunotherapy is based on genetically modified bacterial strain of Salmonella VNP20009 that is able to target and preferentially colonise tumour tissue. Tumour targeting of VNP20009 w...
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Robotic Surgical Device

A robotic surgical device for use in laparoscopic surgery, includes two robotic arms in parallel relationship with each other. Each arm has 7 DOF providing a total of fourteen degrees of movement, accuretaly reproduce the movements of a human torso complete with arms. The device allows a direct co...
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Real Time Dose Verification in Radiotherapy

A team from the Universities of Bristol and Swansea together with University Hospitals Bristol NHS Foundation Trust has developed a novel radiation detector device for determining the dose from Intensity Modulated Radiotherapy (IMRT) in real time. The detector is positioned upstream of the patient (...
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Anti-jaundice composition for corpses and method

The anti-jaundice patent is proven to reverse discoloration caused by jaundice. An added benefit demonstrates the formulation reversing discoloration arising from high medication and post cancer remains. I have additional patentable products available in the same lucrative market....
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Biostimul Pharma

BIODEX:500mg Patent claim BIODEX: calcium clusters (calcium peptide complexes) with modified calcium clusters (calcium peptide complexes)- with enhanced biochemical and biological features, that are extracted by non-chemical, patented process is handled by microscopic particles and they are abso...
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Methodology and Apparatus for the Detection of Biological Substances

Patent has very broad claims which cover various designs and features for biosensors and/or chemical sensors including bio-FET devices. In particular, it covers wireless and non-wireless communications of sensors with a central server or sensors within networks, for example within a distributed r...
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Method and System for Fusing a Spinal Region

A method and system for fusing a region in the spine involve the use of at least one guide tube (10a) to pass instruments and substances into the spinal region in a minimally invasive manner. In the preferred practice of the method, a guide tube is anchored to a vertebra and the guide tube is moved ...
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Systems, Devices, and Methods for Interpreting Movement

According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetogra...
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Ultrasound-based Method and Related System to Evaluate Hemostatic Function of Whole Blood

Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined ...
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Methods and Compositions for Molecular Imaging

Methods for imaging a target cell, tissue, or organ in a subject. In some embodiments, the methods include the steps of (a) administering to the subject a contrast agent that includes a paramagnetic or superparagmanetic material and a targeting moiety that targets the contrast agent to the cell, tis...
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Magnetic Resonance Imaging And/or Spectroscopy Contrast Agents and Methods of Use Thereof

The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be recovered into an observable transition. Coupled with hyperpolarization techniques, this permits the p...
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Single-cell Biosensor for Measuring GPCR Ligand in Test Sample

PROBLEM TO BE SOLVED: To provide a method for measuring the presence and concentration of a GCPR ligand in a test sample including a biological or environmental sample. ; SOLUTION: Provided is the method for the detection of the GPCR ligand in the test sample by using a single cell biosensor express...
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Radiolabled Cyclopamine Assay for the Smoothened Receptor

The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression....
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Methods for single-pass volumetric bidirectional blood flow imaging Spectral Domain Optical Coherence Tomography using a modified hilbert transform

The present subject matter relates to in vivo volumetric bidirectional blood flow imaging using single-pass flow imaging spectral domain optical coherence tomography. This technique uses a modified Hilbert transform algorithm to separate moving and non-moving scatterers within a depth. The resulting...
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Combination for an Adhesive Bonding of Biological Tissues

The present invention relates to a combination, especially for bonding and / or fixation of biological tissues, the combination of components a) a polysaccharide stickstofffunktionalisiertes and b) a terminally functionalized Oligolacton covers....
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Device for ventilating the middle ear, has stent having hollow cylinder which has funnel-shaped expansion at two ends, where inner diameter of hollow cylinder lies in certain range

The device has a stent (10) having a hollow cylinder (12) which has a funnel-shaped expansion (18) at two ends (14,16). The inner diameter of the hollow cylinder lies in the range of 0.5 millimeter to 10 millimeter. The stent has a length in the range of 1 centimeter to 5 centimeter along the longit...
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Method for producing cellulose acetals

Acetalizing poly-, oligo-, di- saccharide or its derivative comprises dissolving the poly-, oligo or di saccharide in an ionic liquid and reacting the obtained mixture with a vinyl ether. Independent claims are included for: (1) acetylated cellulose obtained by the above method; (2) preparation of c...
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Optical Assay System for Intraoperative Assessment of Tumor Margins

The subject matter described herein includes an optical assay system for intraoperative assessment of tumor margins. According to one aspect, the subject matter described herein includes a biological sample containment and illumination apparatus for holding a biological sample for illumination by a ...
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Compositions and Methods for Identifying Ligands of Odorant Receptors

The present invention relates to compositions and methods for identifying odorant-odorant receptor interactions. In particular, the present invention relates to in silico methods for identifying odorant receptor-odorant interactions based on chemical and physical properties of odorant receptors and ...
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Non-regular Electrical Stimulation Patterns for Treating Neurological Disorders

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having re...
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Assessing Pulmonary Gas Transfer in Lungs Using Hyperpolarized 129Xe MRI

A method for providing MRI data of pulmonary gas exchange and/or alveolarcapillary barrier status is disclosed. The method comprises transmitting an RF MRI excitation pulse imaging sequence configured to excite dissolved phase hyperpolarized 129Xe in a gas exchange region of a lung of a subject; and...
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Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering

A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, w...
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Elastin-like polypeptide and gadolinium conjugate for magnetic resonance imaging

A magnetic resonance imaging (MRI) contrast enhancement agent comprising an elastin-like polypeptide (ELP) and one or more paramagnetic metal ions is disclosed. Also disclosed are methods of preparing ELP MRI contrast enhancement agents, formulations comprising ELP MRI contrast enhancement agents, a...
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Method for the Modulation of Function of Transcription Factors

There is provided a method of modulating the function of transcription factor by administering an effective amount of an oligonucleotide containing optimal nucleotide binding sites for the transcription factor. A therapeutic agent having an effective amount of an oligonucleotide for modulating funct...
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Cartesian Human Morpho-informatic System

The present invention is a three dimensional Cartesian coordinate system for the human body, having three perpendicular and intersecting planes. The present invention is based upon the use of the three cardinal planes, in the universally recognized orientations. The cardinal planes in accordance wit...
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Electrogenic pump molecule control

Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. We studied synchronization of the Na/K pump m...
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Device and Method to Facilitate Directed Delivery and Electroporation Using a Charged Stream

A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated b...
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Asymmetric Disc Distracting Cage

An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate ...
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Computer System and Computer-Implemented Method for Providing Personalized Health Information for Multiple Patients and Caregivers

Personalized health information is provided by maintaining a patient profile over time and matching information from the patient profile to appropriate patient-centric information related to that patient's specific medical condition. The patient profile can include a variety of medical information. ...
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Vertebral Body Cage

A intervertebral body device for supporting adjacent vertebrae includes a vertebral body member having at least one containment portion and one communicating portion. The containment portion and communication portion provide two distinct functional regions within the cage. One region of the cage pro...
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Method for Early Detection of Cancers

The invention includes methods for detecting the presence of a neoplastic condition by comparing a sample level of a BIF-1 to a reference, wherein a low level of BIF-1 in the sample correlates with the presence of a neoplastic condition. Another method involves determining the risk of relapse, tumor...
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Method of Detecting Oncogenesis of Hematopoietic Cells

Disclosed in a method of detecting cancer using IL-27 receptors. IL27R is a cytokine receptor identified as a novel oncogene from an acute myeloid leukemia patient. It induces cancer-like properties when expressed in cells and can activate a protein that causes various myeloid cell disorders. The da...
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CT Atlas of Musculoskeletal Anatomy to Guide Treatment of Sarcoma

The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of musculoskeletal structure. The atlas contains a data set representing a 3D model of musculoskeletal structure divided into the relevant musculoskeletal anatomic terminology. The method ...
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Method of Electrogenically Controlling Pump Molecules

Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example i...
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Multichannel Trocar

A multi-channel trocar developed for use in 'minimal-access surgery/single incision laparoscopic surgery. The trocar permits surgical access of two or more articulating laparoscopic instruments or scopes through one skin incision using a dividing membrane to separate the working channels. This allow...
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Control of Harmful Algal Blooms By Induction of Programmed Cell Death

The subject invention pertains to compositions, apparatus, and methods for controlling harmful algae and harmful algal bloom (HAB) based on the induction of the programmed cell death (PCD; apoptosis) pathway in the harmful algae, and to kits for determining algal susceptibility to PCD induction....
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Cubic Silicon Carbide Implantable Neural Prosthetic

An implantable neuronal prosthetic and method of manufacture thereof includes at least one elongated electrode shank adapted for arrangement in the brain having at least one electrode contact disposed on its surface and arranged to electrically couple with said brain. The at least one elongated elec...
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Method and Apparatus for Pulmonary Ventilation Imaging Using Local Volume Changes

The invention provides a novel method of high-resolution quantifiable pulmonary regional ventilation imaging using a package of computer programs, including deformable image registration and local volume change calculation on 4-D or breath-hold CT images. High resolution 3D ventilation images have b...
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Autonomous genosensor apparatus and methods for use

An autonomous genosensor apparatus and methods for use are provided for the field detection and analysis of ambient chemical, biochemical, biologic, biogenetic, and radiologic materials under field conditions in fluid or gaseous environments, such as marine or aquatic environments or industrial proc...
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Biological Active Proteins Having Increased in Vivo And/or Vitro Stability

The present invention relates to biologically active proteins comprising at least two domains wherein a first domain of said at least two domains comprises an amino acid sequence having and/or mediating said biological activity and a second domain of said at least two domains comprises an amino acid...
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Probes and Methods for Detecting Analytes

Embodiments disclosed herein relate generally to probes, methods, and kits for detecting the presence of a target analyte. The probe generally comprises two strands that have regions of complementarity and do not associate with each other at the reaction temperature. In the presence of an analyte, t...
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Methods and Systems for Using Therapeutic, Diagnostic or Prophylactic Magnetic Agents

Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treat...
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Biosensors

Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached ...
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Novel Compositions and Methods for Stimulating Erythropoiesis in a Mammal

The present invention relates to compositions comprising an agent which activates herpes virus entry mediator (HVEM). The present invention also relates to compositions comprising an agonist of HVEM. The present invention also relates to methods of stimulating erythropoiesis in a mammal, comprising ...
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Determination of Site of Origin for a Natural Electrical Pulse in a Living Body

Techniques include determining a first vector of temporal changes in electrical data measured at multiple electrical sensors positioned at corresponding locations on a surface of a living body due to a natural electrical pulse. A different vector of temporal changes in electrical data measured at th...
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Methods and Devices for the Detection of Biofilm

The present invention provides methods and kits for biofilm detection....
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Blood Coagulation Inducing Polymer Hydrogel

The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of ...
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Conjugates of 19F MR Imaging Tracers for Use in Multi-chromic MRI Imaging

Compositions for producing multi-chromic ("color") magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19F imaging tracer (19FIT), conjugated with a magnetic signal modulator, such as a paramag...
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Metal-enhanced Fluorescence for Polarization-based Affinity Assays

A method and kit for determining the quantity of an analyte include providing a functionalized substrate and a reagent. The functionalized substrate includes metallic nanoparticles and a plurality of substantively identical bioactive target molecules affixed to a substrate. The bioactive target mole...
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Arc-Sequencing Technique for Intensity Modulated Arc Therapy

The invention is directed to a radiation therapy method, and in particular, to a method of conducting an intensity modulated arc therapy (IMAT). The invention provides a planning technique that translates traditional static fixed-field IMRT plans into deliverable IMAT plans and allows IMAT to be rea...
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Apparatus and Method for Automating an Enema with Controlled Distension

An apparatus and method are provided for use in administering a rectal contrast enema to a patient to prepare the patient for a medical procedure. A rectal catheter may be provided to facilitate administration of the enema preparation to the patient. The rectal catheter may include a retention ballo...
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Proximal Radius Locking Plate

The invention provides a proximal radius locking plate having a body comprising an elongate shaft portion and a head portion. The plate may have a gentle S-shape and a proximal twist. The shaft portion is adapted for receiving bone screws to fix the bone plate to a shaft of the radius. The head port...
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Fracture-specific Distal Radius Plates

The invention provides an improved distal radius locking plate having a body comprising a shaft portion and a head portion. The shaft portion is adapted for receiving bone screws to fix the bone plate to a shaft of the radius. The head portion includes a first head section and a second head section....
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Electrosurgical Element and Uterine Mainpulator for Total Laparoscopic Hysterectomy

A vaginal cervical retractor used to maneuver and visualize the uterus during various medical examinations and procedures would include an inner tube provided with a movable assembly of plastic cups (cervical cup and vaginal cup) designed to be inserted into the uterine cavity and a retractable elec...
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System and Method for Providing Optimal Concentrations for Medication Infusions

Techniques for medical infusions include determining a first infusion rate for administering a first medication to a patient. A fluid load is determined based at least in part on the first infusion rate. It is determined whether the fluid load exceeds a predetermined threshold based on a fluid maint...
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Composite Images for Medical Procedures

Medical imaging often involves the collective use of information presented in multiple images of an individual, such as images generated through different imaging modalities (X-ray, CT, PET, etc.) The use of a composite of these images may involve image registration to adjust for the variable positi...
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Devices, Systems and Methods for Magnetic-assisted Therapeutic Agent Delivery

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration....
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Contrast Agents

The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins....
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Compositions and Methods Comprising Magnetic Resonance Contrast Agents

The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging....
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Mri Contrast Agents and Related Methods of Use

The present invention relates to contrast agents for MRI and related methods of use....
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Barriers for Facilitating Biological Reactions

The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes....
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Catheters and Electrophysiological Devices

The present invention provides systems and methods of use for catheters and electrophysiological devices. In particular, the present invention provides coronary catheters within which an extendable electrode array is housed....
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System and Method for Leveraging Human Physiological Traits to Control Microprocessor Frequency

A system and method for leveraging physiological traits to control microprocessor frequency are disclosed. In some embodiments, the system and method may optimize, for example, a particular processor-based architecture based on, for example, end user satisfaction. In some embodiments, the system and...
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Biodegradable Nitric Oxide Generating Polymers and Related Biomedical Devices

Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing N2O2- (NONOate) functional group. The polymer can be applied to various medical devices for the treatment of various diseases such as thrombosis and restenosis....
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Compositions and Methods for Imaging Cells

A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the firs...
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Mri Involving Replacement of an Antenna By Another Antenna

A system that incorporates teachings of the present disclosure may include, for example, a Magnetic Resonance Imaging system comprising a Magnetic Resonance (MR) scanner to selectively couple to one among a plurality of antennas without compromising spatial alignment with an anatomical sample during...
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System and Method for Ultrasonic Image Processing

A system that incorporates teachings of the present disclosure may include, for example, an ultrasonic (US) imaging system having a transducer, and a controller managing operations of the transducer. The controller can be operative to cause the transducer to transmit a coded ultrasound signal to an ...
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Imaging of Anatomical Structures

A system that incorporates teachings of the present disclosure may include, for example, an imaging device having a Magnetic Resonance Image (MRI) scanner to generate MRI data associated with soft tissue of a patient, and supply said MRI data to diagnostic equipment that selects one or more normativ...
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System and Method for Prosthetic Fitting and Balancing in Joints

A system and method for prosthesis fitting in joints comprising an artificial condyle and a spacer which cooperates with the condyle to form an artificial joint. The spacer embedded with at least one sensor which is responsive to a force generated between the condyle and the spacer. The artificial j...
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Fret-based Membrane-type 1 Matrix Metalloproteinase Biosensor and Methods for Using the Same

The present invention is a novel FRET-based biosensor composed of ECFP and YPet fluorescent proteins operably linked via a MT1-MMP recognition sequence for use in the detection of cancer cells in a biological sample....
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Quantitative Three-dimensional Mapping of Oxygen Tension

Methods and apparatus are disclosed for measuring and mapping oxygen tension in a tissue and, in particular, permit direct non-invasive measurement of retinal tissue oxygen tension. In one aspect, the invention is directed to methods for determining oxygen tension in a target tissue sensitized with ...
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Temporal Release of Growth Factors from 3d Micro Rod Scaffolds for Tissue Regeneration

The present invention relates to the use of three-dimensional microrod scaffolds for the temporal release of growth factors useful in tissue regeneration, engineering and treatment of disorders....
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Methods and Devices for Capturing Circulating Tumor Cells

A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the c...
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Compositions and Methods for Quantitatively Monitoring Lipids

Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding....
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Non-invasive Optical Imaging for Measuring Pulse and Arterial Elasticity in the Brain

An optical imaging system and a method for generating a report regarding elasticity of arteries in the brain of a subject under test. Light output from the light source of the imaging system non-invasively illuminates at least one blood vessel or region of interest in the brain and, upon the interac...
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Apparatus for Managing a Neurological Disorder

A system that incorporates teachings of the present disclosure may include, for example, a Neuro Sensing and Stimulation Device having a conductive lead for implanting in a brain of a living entity, a sensor coupled to the conductive lead for collecting data associated with one or more electrical si...
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Apparatus for Biomedical Imaging

A system that incorporates teachings of the present disclosure may include, for example, a method involving capturing spectral interference from an optical coherence tomography imaging probe comprising a micro-electro-mechanical system (MEMS) scanning mirror, and a partial reflector for supplying im...
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Method for Multi-scale Meshing of Branching Biological Structures

A structural and functional model for a lung or similar organ is virtually defined by encoding aspects of branching passageways. Larger passageways that are visible in medical images are surface mesh fitted to the anatomical surface geometry. Smaller distal passageways, beyond a given number of bran...
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Contact Tracking Using Wireless Badges

This application discusses apparatus and methods for tracking contacts between various entities in a region. An apparatus includes portable transceiver device having a radio, memory and a power supply. The portable transceiver device can detect and record a history of proximity to other transceiver ...
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Hybrid Laser Ophthalmoscope

Provided is a hybrid laser ophthalmoscope comprising a laser light source, a LED light source, and a holographic diffuser, wherein the holographic diffuser is configured to shape a beam of light into a Maxwellian ring....
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Biologically Active Molecules, Particularly Based on PNA and siRNA, Method for the Cell-specific Activation Thereof, and Application Kit to Be Administered

Biologically active molecules are inactivated for selective activation by target cells by being covalently bonded to one or more peptides each of which has one or more specific amino acid sequences that are selected in respect of enzymes cell-specific for target cells. The bonds, which are broken ex...
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Method and Apparatus for Mapping a Structure

A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the ...
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Mri Contrast Using High Transverse Relaxation Rate Contrast Agent

This document discloses, among other things, a system and method of creating a positive contrast magnetic resonance imaging (MRI) feature using a high transverse relaxation rate contrast agent....
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Coil Element Decoupling for MRI

An RF coil adjacent an imaging region includes a plurality of conducting coil elements, with each conducting coil element including a proximal portion and a distal portion. The RF coil also includes a capacitance between the distal portions of the at least two conducting coil elements. A mutual coup...
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Improved Monitor of Heart Failure Using Bioimpedance

In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a...
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Sensing Tissue Properties

A sensor (100) for in-vivo tissue elasticity measurement is disclosed. The sensor utilises a micro-fabricated structure comprising multiple membranes (120a-c) with varying stiffness and is particularly designed for integration coupled to a medical instrument, such as a probe, an endoscopic tool, or ...
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Automatic Measurement of Speech Fluency

Techniques are described for automatically measuring fluency of a patient's speech based on prosodic characteristics thereof. The prosodic characteristics may include statistics regarding silent pauses, filled pauses, repetitions, or fundamental frequency of the patient's speech. The statistics may ...
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Methods and Systems for Chemical Ablation

Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy....
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Combination Localization System

A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume...
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Thermochemical Ablation System Using Heat from Delivery of Electrophiles

Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. The chemical reaction energy is provided by chemical reactions including a highly reactive electrophilic reagent provided to a target tissue location....
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Dipole Matched Filter for MRI

A method includes receiving k-space data corresponding to magnetic resonance data for a subject and selecting a template for analysis. In addition, the method includes generating an image using the k-space data and using the template....
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Process for Producing a Hyper-Elastic, High Strength Dilatation Balloon Made from Multi-Block Copolymers

A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates,...
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Tracking and Representation of Multi-dimensional Organs

A method includes receiving data corresponding to a sequence of deformations of a surface of an object. The method also includes generating spherical harmonics expressions based on the data. The method includes identifying a subspace of the spherical harmonics expression corresponding to the surface...
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Method for the Production of Bacterially Synthesized Cellulose and Cellulose-containing Material in a Planar Form

The invention relates to a method for producing bacterially synthesized cellulose and cellulose-containing material in a planar form. The aim of the invention is to devise a universally usable method that is suitable for large-scale production and allows homogeneous, planar bacterially synthesized c...
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Process and System for Manufacturing a Customized Orthosis

A process and system for fitting, customizing and manufacturing an orthosis for a subject. 3-dimensional coordinates for a plurality of landmarks corresponding to anatomical characteristics of the subject, means for attachment of the orthosis to the subject, and a reference plane are digitally acqui...
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Upper Arm Wearable Exoskeleton

An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a fir...
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Evaluating Magnetic Resonance Spectra

Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various constituents (e.g., metabolites, macromolecules) of the sample....
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Methods of Identifying Safe NMDA Receptor Antagonists.

Processes are providedfor the identifcation a compound that is useful to treat or prevent a disorder that lowers the pH in a region of affected tissue comprising assessing the difference in potency, or potency boost, of the compound at physiological pH versus disorder-induced pH in a cell that expre...
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Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle

Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprach...
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Compositions, Materials Incorporating the Compositions, and Methods of Using the Compositions and Materials

The invention relates to composition and methods of using described compositions as oxidative catalysis. In certain embodiments, the invention relates to a composition having a nitrogen oxide species, bromide ion, a metal, and oxygen. In certain embodiments, the composition catalyzes sulfides....
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Composite Biomimetic Materials

In an embodiment, composite materials having a fiber of relatively high Young's modulus is embedded in an elastin mimetic material with a relatively low Young's modulus. In an embodiment, the fiber is crimped so as to provide a composite material having a non-linear stress-strain curve, with an init...
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Microelectrode Stimulation for Treatment of Epilepsy Or Other Neurologic Disorder

Methods for treating a neurologic disorder by neurostimulation. The stimulation may be applied using electromagnetic energy. In certain embodiments, distributed electrical stimulation is applied to a target site of the brain in an ongoing fashion. A microelectrode array may be used to provide the di...
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Self-Anchoring MEMS Intrafascicular Neural Electrode

The present invention provides a self anchoring electrode for recording, measuring and/or stimulating nerve activity in nerves and/or nerve fascicles of the peripheral nervous system, and methods for using such a self anchoring electrode....
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Device and Method for the Study of Cell and Tissue Function

A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to c...
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Methods and Devices for Modulating Cellular Activity Using Ultrasound

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, ...
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Neural Interface Assembly and Method for Making and Implanting the Same

An implant assembly for creating a neural interface with a central nervous system having at least one biocompatible intracortical electrode is presented along with a method of making and implanting device. The mechanical, electrical and biological characteristics of the assembly support its use as a...
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Reusable Biosensor Platform

Techniques, apparatus and systems are described for generating reusable and reconfigurable biosensors. A microfluidic device includes a substrate layer and an electrode layer disposed above the substrate layer. A spacer layer is disposed above the electrode layers to form at least two channels. Anot...
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Systems, and Methods for Neurostimulation and Neurotelemetry Using Semiconductor Diode Systems

Methods and systems for neurostimulation and/or neurotelemetry of electrically-excitable biological tissue. Embodiments include implanting single or multiple semiconductor diodes and applying a high frequency electrical volume current. Neurostimulation embodiments include local rectification of the ...
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Digital Amplification

The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable fo...
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Cylindrical Illumination Confocal Spectroscopy System

A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample thro...
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Platelet Function Analysis for Adverse Cardiovascular Events

The present invention relates to methods, compositions, assays and kits for identifying individuals with elevated risk of experiencing an adverse cardiovascular event after coronary or peripheral arterial bypass graft surgery. In particular, the invention relates to a method for identifying an indiv...
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System and Method for Sharing Medical Information

A system and method for sharing information, comprising: creating at least one problem-oriented record utilizing at least one modifier to describe at least one attribute of at feast one problem; and utilizing the at least one problem-oriented record to share information....
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Optical imaging or spectroscopy systems and methods

Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incide...
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Bioreactor System for Mechanical Stimulation of Biological Samples

The subject application provides an apparatus for applying mechanical loading to a biological sample, said apparatus comprising: a bioreactor device configured to house the biological sample, and a load application unit for applying mechanical loading to the biological sample housed in the bioreacto...
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Cellular labeling for nuclear magnetic resonance techniques

The disclosure provides, in part, fluorocarbon imaging reagents and formulations for the ex vivo labeling of cells. Labeled cells may be detected in vivo or ex vivo by a nuclear magnetic resonance technique, such as magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). The discl...
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Magnetically-levitated Blood Pump with Optimization Method Enabling Miniaturization

A magnetically-levitated blood pump with an optimization method that enables miniaturization and supercritical operation. The blood pump includes an optimized annular blood gap that increases blood flow and also provides a reduction in bearing stiffness among the permanent magnet bearings. Sensors a...
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Multi-linked Endoscopic Device with Spherical Distal Assembly

A device for performing a procedure may include an elongate tube having a proximal end and a distal end and an adapted link having a proximal end and a distal end. The distal end may include a first mating surface, where the proximal end may be configured to attach to the distal end of the elongate ...
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A Device for Transfecting Cells Using Shock Waves Generated By the Ignition of Nanoenergetic Materials

A miniature device for generating shock waves using the energy of combustion of a nanoenergetic material and directing the shock waves into biological tissues is described....
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Photoacoustic Detection of Analytes in Solid Tissue and Detection System

A preferred system for detecting an analyte in solid tissue (12), such as an intact lymph node, in vitro includes a laser (22) arranged to generate a pulsed laser beam into solid tissue, which can be a fully intact lymph node. An acoustic sensor, and preferably at least three acoustic sensors (20a, ...
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Optical Spectroscopy Device for Non-invasive Blood Glucose Detection and Associated Method of Use

An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a...
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Method and Apparatus for Cancer Screening

A method and apparatus for detection of pteridine levels in a biological sample using CE-LIF which is useful for early cancer screening involving fully oxidizing pteridine compounds in a sample such as a urine sample, subjecting to CE-LIF to assess compound concentration, and compare to expected lev...
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Method and System for Non-invasive Optical Blood Glucose Detection Utilizing Spectral Data Analysis

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. A variety of techniques are disclosed for improving signal-to-noise ratio in the acquisition of spectral data and calculating attenuance of light attributable to blood i...
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Controllable Magnetic Source to Fixture Intracorporeal Apparatus

A first magnetic field can be produced across a tissue region using a first magnetic field source, providing a magnetic coupling force between the first magnetic field source and a first object, wherein the first object provides a magnetic field or a magnetic susceptibility to obtain the magnetic co...
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Methods, Devices, and Systems for Bone Tissue Engineering Using a Bioreactor

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image -based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex th...
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Methods, Devices, and Systems for Chemiluminescence-based Microfluidic Cell Counting

A chemiluminescence-based detection system and method for counting blood cells by capturing and isolating target blood cells flowing through a microfluidic chip and detecting light emitted by the captured target blood cells....
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Filter Blood Fluid Channel Methods, Devices and Systems

A risk of thrombogenesis is minimized in a tubular fiber membrane filter by flowing blood or other fluid through a header manifold that ensures a minimum shear rate on the wetted surfaces without flow reversal, stagnation volumes, or a shear rate that is too high. In an embodiment, fluid is conveyed...
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Systems and Methods of Microfluidic Membraneless Exchange Using Filtration of Extraction Outlet Streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which ...
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Multi-layer Blood Component Exchange Devices, Systems, and Methods

A microfluidic separation device suitable for high throughput applications such as medical treatments, and associated methods and systems, are described. Embodiments are suitable for treatment of end stage renal disease....
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Systems and Methods for Dynamic Imaging of Tissue Using Digital Optical Tomography

A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of ...
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Active Cmos Sensor Array for Electrochemical Biomolecular Detection

Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enh...
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Methods, Apparatus and Systems for Magnetics Stimulation

A coil suitable for tissue stimulation and especially for transcranial magnetic stimulation (TMS) may be used in conjunction with a pulse generator to induce electric field in the brain with less attenuation in depth compared to existing TMS coils. In an example, a coil winding is formed in a soleno...
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Fluid Separation Devices, Systems and Methods

A membraneless separation device can be applied to a variety of treatments, such as the ultrafiltration of blood for a patient with end stage renal disease. An ultrafiltration device can include a membraneless separation device, which separates an incoming blood flow into a substantially cytoplasmic...
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Systems, Methods, and Devices for Microbubbles

A suspension of gas-filled microbubbles can be synthesized by sonicating a lipid solution and a first gas in a reaction volume. The resulting microbubble suspension can be stored for later use, for example, for infusion into a patient for gas delivery thereto. Various techniques can improve the shel...
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Device, Apparatus and Method for Providing Photostimulation and Imaging of Structures

According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds ...
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Improved Apparatus and Method for Assessing Visual Learning

An improved test apparatus and method for assessing visual learning in mammals is provided. The stimuli presented to the mammal are disposed and arranged on the floor of the test apparatus instead of on the walls....
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Method and Apparatus for Model-based Detection of Structure in Projection Data

In one aspect, a method and apparatus for determining a value for at least one parameter of a configuration of a model associated with structure of which view data has been obtained including detecting at least one feature in the view data, and determining the value for the at least one parameter of...
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Systems for and Methods of Assessing Urinary Flow Rate Via Sound Analysis

Systems for and methods of assessing urinary flow rate via sound analysis. Embodiments of the uroflow measurement systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The urofl...
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Breath Biofeedback System and Method

A breath biofeedback method and system for encouraging a subject to modify respiration. The system includes a thoracic volume input module measuring thoracic volume data of the subject and a pattern module providing target breathing patterns in communication with a display generator. The display gen...
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Systems for and Methods of Assessing Lower Urinary Tract Function Via Sound Analysis

Systems for and methods of assessing lower urinary tract function from urinary flow data via sound analysis and user-provided information regarding the lower urinary tract symptoms (LUTS) of frequency, urgency and urge incontinence. Embodiments of the LUTS assessment systems include a computer and a...
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Methods, devices and apparatus for imaging for reconstructing a 3-D image of an area of interest

Featured are methods, devices and apparatuses for imaging tissue, such as cardiac tissue, using any of a number of imaging techniques (e.g., ultrasonic imaging techniques) and a 3-D tracking system. In embodiments, such methods, devices and apparatuses are configured so that a 3-D image can be recon...
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Device for Perineal Massage and Method of Use

A number of studies have been performed that demonstrate beneficial effects of perineal dilation and/or massage during pregnancy to reduce episiotomy and perineal trauma at birth. The invention includes a perineal massage device including a retractor portion attached to the unified end of a bifurcat...
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Method and System for Detecting Lung Tumors and Nodules

A method and system for detecting tumors and nodules in a lung tissue are provided. The method includes the steps of (a) providing a plurality of asymmetric templates of at least one 3D appearance model of a nodule; (b) providing a 3D imaging data set of the entire area of a tissue; (c) matching the...
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Pulse Measurement Apparatus and Method

An embodiment of the invention is directed to a pulse measuring system that measures a characteristic of an input pulse under test, particularly the pulse shape of a single-shot, nano-second duration, high shape-contrast optical or electrical pulse. An exemplary system includes a multi-stage, passiv...
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Medical Apparatuses Incorporating Dyes

The invention provided medical apparatuses incorporating dyes to facilitate proper positioning in patients, and methods for their use. The apparatuses can be, for example, tubes, catheters, or needles. In some embodiments, the dye is a near infrared fluorescent dye....
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Method for Controlling Photodynamic Therapy Irradiation and Related Instrumentation

In a first embodiment, there is no monitoring, and instead light is delivered according to a predetermined "recipe." In a second embodiment, the instrumentation provides a means for making the reflectance measurements during therapy without requiring the brief interruption. This device may therefore...
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Automated Placental Measurement

A method for analyzing the placenta in two or three dimensions comprising: selecting one or more placenta! samples to be analyzed; obtaining a digital image of each placenta! sample: and performing an analysis on the digital images, wherein a mathematical algorithm is applied to the digital image, T...
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Methods and Apparatus for Differential Phase-contrast Fan Beam Ct, Cone-beam Ct and Hybrid Cone-beam Ct

A device for imaging an object, such as for breast imaging, includes a gantry frame having mounted thereon an x-ray source, a source grating, a holder or other place for the object to be imaged, a phase grating, an analyzer grating, and an x-ray detector. The device images objects by differential-ph...
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Method and Apparatus of Cone Beam Ct Dynamic Imaging

A cone-beam scanning system scans along a half circle. The reconstruction uses a weighting function which decreases for rows farther from the scan plane to take the redundancy of the projection data into account. Another embodiment uses a circle plus sparse helical scan geometry. Image data can be t...
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Photoacoustic Imaging Using a Versatile Acoustic Lens

To image various soft tissues in the body using pulsed laser optical excitation delivered through a multi-mode optical fiber to create photoacoustic impulses, and then image the generated photoacoustic impulses with an acoustic detector array, a probe includes either a mirror and an acoustic lens or...
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Low-cost Device for C-scan Photoacoustic Imaging

The prostate gland or other region of interest is stimulated with laser light, resulting in ultrasound waves (photoacoustic effect) which are focused by an acoustic lens and captured by a specific 1- or 2D sensor array and subsequently displayed as a C-scan on a computer screen. The amplitude of the...
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Respiratory Disease Monitoring System

An automated system for monitoring respiratory diseases, such as asthma, provides noninvasive, multimodal monitoring of respiratory signs and symptoms that can include wheeze and cough. Some embodiments employ a mobile device, such as a cell phone, in which raw data from a microphone and an accelero...
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Robotic Localizing Aid for High Intensity Focused Ultrasound Delivery

A holding structure holds a biopsy needle and a HIFU transducer to allow smooth and accurate delivery of the HIFU beam at the interface of the liver, where bleeding will occur. This manipulator structure performs the biopsy and HIFU through the percutaneous approach. In addition, the procedure is im...
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Apparatus and method for cone beam volume computed tomography breast imaging

Cone beam volume CT breast imaging is performed with a gantry frame on which a cone-beam radiation source and a digital area detector are mounted. The patient rests on an ergonomically designed table with a hole or two holes to allow one breast or two breasts to extend through the table such that th...
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High-frequency Oscillatory Ventilation Monitoring Method and System

A method of monitoring high frequency oscillatory ventilation (HFOV) wherein the oscillatory movement of the chest wall of an individual is measured. An average amplitude is determined and compared to a pre-determined baseline amplitude, which is established by using the average amplitude at a parti...
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Magnetic Tweezers Method to Measure Single Molecule Torque

A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device....
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Decontamination Apparatus

A decontamination apparatus including an enclosure, a first and second decontamination system within the enclosure where the first and second decontamination systems rely on different methods of decontamination....
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Cerebral Vascular Reactivity Monitoring

A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The corre...
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Extracorporeal Organ Conservation

The invention relates to an arrangement for extracorporeal organ conservation. Said type of arrangements are used to artificially preserve or to regenerate vital functions of organs, said organs also having extremities and tissue lobes. The inventive arrangement for extracorporeal organ conservation...
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New vaccine strains having two or three different attenuation active metabolic drift mutations, which result in smaller colonies with corresponding longer generation time and correlated attenuation de

Vaccine strains having two or three different attenuation active metabolic drift mutations, which result in smaller colonies with correspondingly longer generation times and correlated attenuation degree, with respect to reduced growth intensity, against the respective wild strains, are new. An inde...
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Modular System of Functional Units for Mixing, Processing And/or Separating Samples for Use in Biological/medical Research and for Diagnostics

Basic steps of biological research and of diagnostics include mixing, physical and/or chemical reactions and separation. Particularly in research task-specific laboratory systems are required which are not commercially available due to small batch sizes and the specific problems to be faced. Because...
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Aurora Kinase Inhibitors Compounds.

The present invention relates to novel compounds of formula (I) that inhibit cell proliferation, in particular by inhibiting selectively Aurora A kinase activity and to their use in medicine, in particular for treating, ameliorating or preventing hyperproliferative diseases. The invention further re...
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Bi-plane X-ray Imaging System

A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of nearly any motion or joint. The radiographic equipment can be mounted in a gantry system that provides suffi...
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Manipulation, Detection, and Assay of Small Scale Biological Particles

Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. A particle manipulation device contains a plurality of electrodes formed on an active semiconductor layer of an integrated circuit chip, where the electrodes and gap spacing betw...
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Method and System for Acquiring Loundness Level Information

The present invention relates to methods for acquiring hearing threshold values in a subject comprising providing a sound to the subject; providing a monitor for monitoring a movement response by the subject; monitoring the movement response by the subject to the sound; and progressively reducing th...
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Non-contact Frequency Domain Near Infrared Absorption (inir) Device for Assessing Tissue Damage

A device for measuring the progress of healing of a wound over time includes at least one diode laser source that provides respective input wavelengths into at least one source fiber, a first optical switch that sequentially switches wavelengths among the respective input wavelengths into the at lea...
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Tubular Floating Electrode Dielectric Barrier Discharge for Applications in Sterilization and Tissue Bonding

Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode i...
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System and Method for Evaluating Tissue

A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly...
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Control of Mucus Membrane Bleeding with Cold Plasma

The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-the...
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Methods for Beaming

Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plas...
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Nucleic Acid Expression Construct and Its Use As a Cell Proliferation Marker

In a first aspect, the present invention provides a nucleic acid expression construct encoding a fusion protein comprising a reporter protein and a protein with a wild-type destruction signal, wherein the sequence encoding the fusion protein is operably linked to a non-endogenous promoter, and where...
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Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer

The present invention discloses compositions of facially amphiphilic polymers and oligomers and their use in methods for treating or reducing cancers in humans or animals....
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Methods for Making Embryonic Cells, Embryos, and Animals Sensitized to Stress

Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a secondary treatment with a stress inducer, e.g. heat shock or chemical inducer. Accordingly, the present...
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Porous Expansion Bolt

A biocompatible expansion bolt includes a central screw and an expansion shell positioned about the central screw. The expansion shell is shaped and dimensioned for controlled expansion between a first diameter and a larger, second diameter, wherein die expansion shell is composed of porous material...
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Ribosome structure and protein synthesis inhibitors

The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The i...
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Protein Chip for Screening of Protein Activity

The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in...
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Apparatus, Systems and Methods Utilizing Plethysmographic Data

Disclosed are apparatus, systems and methods utilizing attributes of the cardiac signal to calibrate/normalize components of the plethysmographic (PG) waveform indicating changes in venous and arterial blood volume. In the time-domain, amplitudes of respiratory-induced variations of the DC and AC co...
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Dynamic Spine Stabilizer

A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured spine. The dynamic spine stabilizer includes a support assembly and a resistance assembly associated with th...
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Microrna Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors

The invention provides a papillary serous miRNA signature and methods for determining the identity, origin, and stage, of concurrent endometrial and ovarian papillary serous tumors. Exemplary origins of concurrent endometrial and ovarian tumors include, but are not limited to, the uterus, ovary, fal...
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Smart Structures for Bone Prosthesis

This invention relates to structures to be applied in bone prostheses and it refers to a multi-network concept of biosensors and bioactuators that continually and actively monitor the performance and integrity of bone implants inside living organisms. The biosensors network contemplates different se...
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Intracellular Device which Can Be Used As a Biological Activity Sensor Element Or Actuator

The invention relates to an intracellular device which can be used as a biological activity sensor element or actuator, formed by or based on silicon (monocrystalline silicon with crystallographic orientation (100), polysilicon or silicon oxide), having lateral physical dimensions of between 50 nano...
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Flourinated material

This invention relates to a method for modifying the surface of a material for use with a biological sample or tissue comprising the steps of providing a material having a surface which comprises reactive-functional groups; providing fluorinated molecules having reactive-functional groups compliment...
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Targeted Induction of Aggregation of Proteins with Cross Beta Structures

The present invention belongs to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as aggregator, that has a specificity for a target protein and which induces aggregat...
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Single Domain Antibodies Capable of Modulating Bace Activity

The present invention relates to single domain antibodies with a specificity for BACE1. More specifically, the invention provides single variable domain antibodies derived from camelids which bind to BACE1 and are capable of inhibiting the activity of BACE1. Said antibodies can be used for research ...
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Multifunctional Stealth Nanoparticles for Biomedical Use

The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and thera...
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Gallium-doped Phosphocalcic Compounds

The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7, wherein 0 < x < 1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and t...
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Bacteria Having Protecting Activity Against Botrytis Cinerea

The invention relates to bacteria having protecting activity against Botrytis cinerea: said bacteria are selected from the strains Acinetobacter, Bacillus, Pantoea and Pseudomonas. Application in the biological control of Botrytis cinerea....
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Method of Toxicological Assessment

A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function; and correlating th...
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Capillary electrochromatography (CEC) analytical separation analysis device and method

A capillary electrochromatography (CEO) analytical separation analysis device. The device comprises a stationary phase fabricated at least partially from a conducting or electroactive polymer e.g. polyaniline (PANI). By applying a potential to the stationary phase it is possible to modify or control...
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Amnion Epithelial Cells for the Treatment of Degenerative Disc Disease

An orthopaedic device and methods for the treatment of degenerative disc disease (DDD) are disclosed that utilise cells such as multipotent amnion epithelial cells (AECs) and/or mesenchymal stem cells (MSCs) that may be directed towards a disc cartilage type cell for the in situ generation of interv...
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Platelet Aggregation Using a Microfluidics Device

A microfluidics device to provide real time monitoring of platelet aggregation of a biological sample obtained from a subject. The device comprises a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear accelera...
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Antibody

The invention relates to antibodies to Aspergillus species and to methods of producing those antibodies. The invention also relates to the use of such antibodies in identifying the presence of the Aspergillus species and to methods of treating an infection with the Aspergillus species....
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Photonic Biosensor Arrays

This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising...
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Method for Fabrication of Photonic Biosensor Arrays

This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field. A method for the fabrication of a biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultan...
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Method for Producing Multiple Modifications in the Chromosome of Gram-negative Bacteria and Salmonella Strains which Are Deficient in C-di-GMP Synthesis Obtained By Said Method

The method can be used to make multiple modifications in the genome of Gram-negative bacteria, simply and efficiently, using the plasmids of the invention, which comprise a marker gene under the control of a constitutive promoter, a replication origin specific for Gram-negative bacteria, a gene whic...
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Antimicrobial Composition

The invention provides antimicrobial compositions comprising a terpenoid in combination with an antimicrobial agent, and uses of such compositions in various applications involving preventing, combating or treating microbial infections, or preventing microbial growth or establishment....
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Process for Providing Embryonic Stem Cells

Embryonic stem sells, particularly human embryonic stem cells are outstandingly sought as subjects of research owing to their capability for reproduction and differentiation in many, if not in all, cell types in a body. Herewith described invention in the application reveals the procedure according ...
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Controlled Production and Delivery of Biologically Active Agents By Gut Bacteria

The invention provides gut commensal bacteria that have been modified to express one or more biologically active polypeptides or protiens, the bacteria includes a promoter, such as a xylanase promoter, which is induced in response to the presence of xylan in the diet and which regulates the expressi...
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Human Immune Therapies Using a CD27 Agonist Alone Or in Combination with Other Immune Modulators

Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These method...
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Total Plasma FVI I /FVI IA Levels As Indicators of Pre-eclampsia of Pregnant Females

Raised total plasma FVII protein, including activated FVII (FVIIa) in pregnant females, compared with total plasma FVII protein in normal pregnancy, has been found to be an indicator of the pregnancy complication of pre-eclampsia....
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Materials and Methods Relating to Cell Based Therapies

The invention relates to the provision of a novel cell population that can be used for tissue regeneration and the treatment of disease states associated with cell degeneration for age related tissue changes. The cell population are derived from adult stem/progenitor cells which are characterised by...
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Methods of Analysing Homeostatic State in Cell Systems

The invention relates to a method of analysing the homeostatic balance of a population of cells, which includes the following steps: a) label one or more cells in the population b) incubate the cells for a time t c) determine the clone size distribution of labelled cells at time t d) determine if th...
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Transgenic rodent expressing truncated disc 1

The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia- related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncatedDis...
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Magnetically-controlled micro-fluid system for e.g. 'lab-on-chip' system for determination of presence of bio-molecules, virus, biological cells

A micro-fluid system transports tiny particulate quantities of a biological or pharmaceutical liquid sample through a channel exposed to the effect of a magnetic force generated nearby. The channel is exposed to two or more magnetic sources, each separated from the other. - The magnetic force is gen...
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Method and Reagent for the Specific Identification and Quantification of One Or More Proteins in a Sample Using in Particular Inductively Coupled Plasma-mass Spectrometry

The invention relates to a method for the identification and quantification of one or more biomolecules in a sample containing a mixture of substances, wherein said method comprises the steps of, a) providing a sample which contains one or more biomolecules, b) providing a reagent for the analysis o...
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Microginin Producing Proteins and Nucleic Acids Encoding a Microginin Gene Cluster as well as Methods for Creating Novel Microginins

The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature....
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Chitosan Green Tea Polyphenol Complex for Wound Healing

In recent years, oxidative stress has been implicated in a variety of degenerative process and diseases, including acute and chronic inflammatory conditions such as wound healing. Green tea polyphenols have shown anti-oxidant property. The present study discussed the application of chitosan green t...
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Label-Free Protein Detection

Background Conventional methods to detect the presence or quantity of specific proteins or other molecules in biological samples rely on the use of target-specific probes such as antibodies, which can be detected via chemical tags or fluorescent labels. However, conjugating labels to proteins can ...
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A Novel Therapeutic Strategy for HIV Infection

BACKGROUND: Tat is an HIV regulatory protein that is essential for viral replication and HIV disease progression. It critically regulates HIV transcription and allows the generation of full-length transcripts necessary for the formation of virus particles. Tat is also found in the circulation and ca...
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Moisture-Resistant Adhesive Polypeptides

BACKGROUND: Surgical tissue adhesives provide an alternative to suturing, packing, or stapling planes of tissue together. Use of adhesives for wound closure is desirable since adhesives can be very fast acting and assure complete closure. Marine adhesives (such as those used by barnacles) can functi...
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Sol-gel-coated Implantable Devices

Highlights Method for coating uneven surfaces with sol-gel polymers Current coating methods unable to provide complete, uniform coating of non-contiguous surfaces such as those found in stents and orthopaedic screws Sol-gel polymers can incorporate therapeutic, antibacterial, or other materials t...
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Quantum Dot Processing

Background Semiconductor nanocrystals, or quantum dots (QDs) have received great interest from the biological and medical communities in the last few years. This interest can be largely attributed to the unique optical and electronic properties of QDs and their advantageous properties over organ...
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Integrated Fluidics System for Simplifier Analysis of Aerosolize Biological Particles

An integrated fluidics system for simplified analysis of aerosolize biological particles has a unitary self-contained ticket provided with a sample fluid reservoir, an array of particle-detection strips, which is located adjacent to the sample reservoir, and, optionally, a cleaning fluid reservoir a...
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Novel Patterning Techniques for DNA-sensing Microarray Fabrication

DNA microarrays typically consist of a glass slide with an array of polyacrylamide gel pads. One commercially available microarray coats a glass slide with acrylamide gel, then photopolymerizing the acrylamide to create the array of square pads. “Probe” DNA is deposited and linked to the polyacry...
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DNA Sensor with Electronic Transduction

Fluorescence-based detection of nucleic acid has several drawbacks. First, it requires that fluorescent tags be chemically attached to target nucleic acid. Next, fluorescent tags have a lifetime, after which they bleach, which limits sensitivity and archiving. Finally, fluorescent readout technology...
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Purification and Concentration of Proteins from Complex Samples Using Aptamers and the Interaction between Nucleic Acids and Silica

There is a need for an inexpensive, efficient, automated device for the preparation and analysis of samples that comprise both DNA and proteins. Generic methods for the purification of DNA from cells or mixtures of cells include alcohol precipitation, silicon binding, standard gel electrophoresis, a...
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Microfabricated Substrate for the Collection of DNA (Micro-sandpaper)

-------------------------------------------------------------------------------- Microfabricated Substrate for the Collection of DNA (Micro-sandpaper) Reference#: P02331 -------------------------------------------------------------------------------- Conventional forensic DNA detection t...
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Intelligent Fusion of Multi-modal Biometric Inputs for Decision Making

While techniques provide some beneficial results, they do not effectively utilize all of the information available to a score-level fusion system, including score values, quality estimates, and score distribution statistics. APL's Process for Multi-Biometric Fusion provides expandable, Bayesian ...
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Thermally Induced Decontamination Environments

Current Environmental Decontamination technologies require chemical approaches or alternately require extremely high temperatures. Chemicals used tend to be hazardous and costly to the environment or the targeted area. Paraformaldehyde gas, glutaraldehyde, hydrogen peroxide and peracetic acid also w...
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Wireless Wearable Electronic Tags for Patient Triage

For years, emergency medical response teams have relied on paper triage tags, clipboards of notes, and voice communications (using telephones and hand-held radios) to share patient information. This workflow, however, has proven labor intensive, time consuming and prone to human error. With the star...
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An Unclad Fiber Optic Sensor for Measuring Chromophoric Compounds in Human Blood and Amniotic Fluid

Yellow or brown tinged skin and eyes are the hallmarks of jaundice – seen most often in infants. The yellowing is a result of elevated levels of a substance called bilirubin in the blood (hyperbilirubinemia). Hyperbilirubinemia is commonly seen in 50-70 percent of newborn babies and is the most comm...
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Enhanced Optical Methods to Break Spore Coating

There is a need for rapid and accurate detection of bacterial spores such as Bacillus anthracis. Currently, two detection techniques are being used to rapidly identify bacterial spores. These techniques are MALDI_MS and PCR-amplification. These techniques identify the spores by evaluating biomarkers...
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Electrode Array to Determine Specific Axonal Firing in a Peripheral Nerve

Researchers and scientists at the APL have been trying to find better ways to communicate amputees’ brains with the reflexive movements of their missing parts – ways that are reliable, precisely coordinated and non-invasive. Under normal circumstances, our brain indicates actions that should take pl...
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Using Wearable Biometrics for Continuous Automated Authentication

Biometrics use biological features such as fingerprints to determine an individual’s identity by comparing the observed fingertip patterns to a previously stored pattern. Biometrics are useful for controlling access to devices - such as laptops - or to facilities. One drawback, however, is the user-...
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Assisted Drug Delivery Device

Transporting drugs to specific and appropriate tissues of the body is not a trivial issue and can be more important than the benefits of the drug itself. Characteristics of the target tissue and of the drug chemistry must be considered before a treatment can be effective. Delivery issues are largely...
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Soluble, Processible Molecularly Imprinted Macromolecules

The scientific community's excitement for the use of molecularly imprinted polymers (MIPS) for sensors and filters is rising at an almost exponential rate, with the practical realization that plastics holding impressions of molecules could revolutionize many important aspects of drug discovery, medi...
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Variable Angle Linear Slot Scanning Digital X-ray Device

This new, multipurpose device allows a greater number of radiologic studies from a single machine. In addition to the functionality of conventional digital x-ray and tomography machines, the linear slot scanning feature of this unique device will also allow full body x-ray scans, x-ray scans of spec...
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X-Ray Cassette Alignment and Centering System

The x-ray department is a principle source of income for hospitals and private practices. On average, 6% to 10% of all x-rays need to be repeated to produce an acceptably diagnostic radiograph. Of these repeat exams, most are for chest, abdomen, pelvis and spinal imaging. A primary reason for this r...
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Ocular and Microsurgery Device Controlled by Artificial Muscles

Minimally invasive surgery techniques are less traumatic to the patient. They are significantly less painful, provide less chance of infection, less post-operative services and generally make recovery easier and faster. The breakthrough technologies that make operating procedures more efficient and ...
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Pressurized Drinking System (PDS)

Your heart is beating as the alarm signal continues to bleat out its warning, which for you – a bio-chemical specialist with the military fighting forces – means you need to suit up and report directly to the hazardous environment where you will be required to assess and remediate the nuclear, chemi...
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MRI Flex Circuit Catheter Imaging Coil

There is a need for higher resolution imaging of heart tissue particularly for treating arrhythmias and atrial fibrillation using catheter ablation methods. While cardiac electrodes for measuring voltage potentials due to arrhythmias have been performed before using a flex circuit, the use of flex c...
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Non-invasive Health Monitor

The APL Non-Invasive Health Monitor, in its various forms, will provide a method of evaluating cardiovascular and respiratory status, and autonomic balance and therefore provide insight into physiological or psychological stressors that may be negatively impacting the health of the individual. The s...
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A Microfabricated Array Sensor for the Electrochemical Detection of Biological Molecules

The ability to detect ultra low concentrations of heme and hemoglobin in bodily fluids has great value in clinical and medical diagnostic applications. Clinical screening for many diseases, such as colorectal cancer and malaria, is predominantly related to the concentrations of hemoglobin or heme in...
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Adaptive Analysis Framework

This technology, the Adaptive Analysis Framework (AAF) is a novel design and maintenance plan for large databases associated with biological and medical research problems or clinical assessments that make use of large scale data sources within multiple and separate laboratory facilities. The framewo...
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A New Class of Anticancer Drugs

Adrenocortical carcinoma generally carries a poor prognosis. No effective therapies have emerged to treat or cure this disease. Radical surgical excision is the treatment of choice for cancers that have not spread to other organs. Surgery is the treatment of choice, except when there is evidence of ...
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Combined Chemical/Biological Agent Detection by Mass Spectrometry

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Autonomous Ingestible Probe for Diagnosis and Therapy of Gastrointestinal Lesions Using Fluorescent Molecules

Current technology for diagnosis and therapy of gastrointestinal lesions has no ability for functional imaging, has limited specificity of tumors, no therapeutic capability, and provides no assessment of treatment efficacy. The Johns Hopkins University Applied Physics Lab has developed a “pill” t...
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The Use of Laser Desorption and Matrix Assisted Laser Desorption Ionization Mass Spectrometry for the Detection of Occult Blood in Biomedical Applications

Methods are described for detecting and quantifying occult blood in a biological sample using laser desorption mass spectrometry (LD MS). Biological samples that can be analyzed using various embodiments of the present invention include stool (fecal occult blood, FOB), and any bodily fluid including...
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A Highly Sensitive Procedure for the Detection of Blood in Stool for Indications of Colon Cancer, Internal Bleeding, Disease and Other Traumas

Malaria is a debilitating, infectious disease characterized by chills, shaking and periodic bouts of intense fever. Each year, there are an estimated 400 million to 600 million cases of malaria and 2.7 million resulting deaths, worldwide. Malaria is found in many locations of the tropical world and ...
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Cortisol Sensor for Soldier Stress and Fatigue Monitoring

The hormone cortisol, which is produced by the adrenal gland and is released in the body during stressed or agitated states, has gained widespread attention as the so-called "stress hormone." But this hormone is more than a simple marker of stress levels- it is necessary for the functioning of almos...
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Surface Structure Measurement Device

Current means of assessing surface roughness at the 5 micrometer scale size and at surface roughnesses of a few micrometers consist of stylus probes or optical scatterometers. Such devices are not practical for measurement of tooth surface structure in vivo. The Johns Hopkins University Applied P...
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Remote Screening and Diagnosis of Malaria and Other Blood Borne Parasites

Malaria is a debilitating, infectious disease characterized by chills, shaking and periodic bouts of intense fever. Each year, there are an estimated 400 million to 600 million cases of malaria and 2.7 million resulting deaths, worldwide. Malaria is found in many locations of the tropical world and ...
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Methods and Devices for Detection and Diagnosis of Malaria

Malaria is a debilitating, infectious disease characterized by chills, shaking and periodic bouts of intense fever. Each year, there are an estimated 400 million to 600 million cases of malaria and 2.7 million resulting deaths, worldwide. Malaria is found in many locations of the tropical world and ...
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Low-cost Flexible Manufacturing Techniques for Bradbury-Neilson Gates and Similar Interdigital Structures for Use in Miniature Time-of-Flight Mass Spectrometers and Other Related Applications

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Portable Ventilator with a Manifold-Muffler System

Portable ventilators are self-contained, lightweight life support devices used to provide ventilation, oxygen and diagnostic capabilities at the scene of an accident- when it is most critically needed - which substantially reduces fatalities. This novel component reduces the ventilator’s size and we...
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Techniques for Deriving Tissue Structure from Multiple Projection, Dual-Energy X-ray Absorptiometry

The present invention relates to dual-energy x-ray absorptiometry for tissue properties; and, in particular to techniques for deriving bone structure, bone strength, and risk of injury, including risk of fracture, from multiple projection dual-energy x-ray absorptionmetry images. Patent Status:...
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Patient Initiated Emergency Response System (PIERS)

More than one million Americans will suffer an acute myocardial infarction (AMI) this year. Within the first 60 minutes of chest pain, 250,000 will die. Before reaching any medical attention, a total of 375,000, (one-third) will die. Current studies strongly suggest that time-to-treatment is an impo...
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Patient Initiated Emergency Response System (PIERS)

More than one million Americans will suffer an acute myocardial infarction (AMI) this year. Within the first 60 minutes of chest pain, 250,000 will die. Before reaching any medical attention, a total of 375,000, (one-third) will die. Current studies strongly suggest that time-to-treatment is an impo...
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Large Region Spatio-Temporal Biosurveillance System

There are significant limitations with previous attempts at constructing early warning bio-surveillance systems. Conventional bio-surveillance focuses on categorical data collected from emergency rooms, clinics, and other healthcare facilities. The detection algorithms in these conventional systems ...
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Ambulatory Health Monitor

The Ambulatory Health Monitor is a miniaturized, self-programmable, stand-alone device that logs changes in various physiological parameters over extended periods of time. The data collected by the monitor can be easily downloaded to a remote device. With the proper sensors, the monitor can coll...
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Thermal Pain Probe

The loss of nerve fiber density or function, neuropathy, can result from disease or injury such as diabetes or burns. Assessment of the response of small nerve fibers found in the skin can indicate the degree of damage and the effects of treatment. JHU/APL has developed a handheld device to deliv...
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Blood Iron Removal for Suffers of Hemochromatosis Using a Selectively Permeable Molecularly Imprinted Polymer Dialysis Membrane

The ability to remove a specific component from its environment has immediate and profound applicability on environmental and medical fronts. Currently, filtering devices that can selectively and completely remove environmental phosphate and nitrate do not exist. Present systems are able to achi...
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The Cardiac Auscultatory Recording Database (CARD): an Internet-based Software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation

Current medical training techniques rely on significant patient contact, resulting in high training costs and often not the expected outcomes. In a 1997 study published in The Journal of American Medical Association, researchers found that on average, internal medicine and family practice residents ...
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Airborne Pathogen Neutralization

So far there is no effective way to disinfect or neutralize airborne pathogens in large volumes of contaminated air in real time to protect citizens against a terrorist attack using biological weapons, or to disinfect air in hospitals. The present inventions provide an apparatus and methods for n...
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Intra- and Inter-Body Wireless Communication and Modular-Payload Capsules

Current "capsule cam" type technologies typically use electromagnetic radiation with limited payloads and provide one-way communication. The JHU/APL "Intra- and Inter-Body Wireless Communication and Modular-Payload Capsules" technology eliminates the exposure to electromagnetic radiation, provides f...
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Method and Apparatus for Imaging and Spectroscopy of Tumors and Determination of the Efficacy of Anti-tumor Drug Therapies

Cancerous tumor growth is dependent on a process called angiogenesis wherein factors secreted by a tumor cause surrounding normal tissue to produce new blood vessels that enter the tumor and support its growth. This so-called neovascular growth is essential to tumor survival and growth. They also re...
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Refreshable Tactile Computer Display for the Blind

To make computer systems accessible to visually impaired users, a tactile display with multiple tactile elements that can be touched by a user serves many purposes. A tactile display with two positions for the tactile elements (raised and lowered) can be used to form Braille characters that can be s...
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Use of Cytokines and Other Host Cell Response Molecules Collected from Breath as Non-Invasive Method to Detect Infectious Disease

A novel non-invasive point-of-care method to rapidly assess for disease is being developed. The exhaled breath condensate is the non-gaseous portion of the breath that is made up of aerosolized fluids and proteins secreted from the epithelial cells that line the walls of the lung. If properly collec...
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Transdermal Optical Communication System

applications of medical devices, telemedicine, and wireless medical diagnostics, there is the need to communicate with such devices implanted in the human body. The Johns Hopkins University Applied Physics Lab has conceived a method to communicate via optical link through the skin. An informatio...
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Plasminogen Activator to Prevent Haze After Laser Eye Surgery

Some fraction of patients who have laser vision correction develop haze (cloudy vision) several months after the surgery: about 8% to 10% of photorefractive keratectomy (PRK) patients and a smaller fraction of laser in situ keratomileusis (LASIK) patients. At present there is no pre-surgical predict...
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Time-of-Flight Mass Spectrometer Array (TOF Spectrarray)

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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The TeleWatch Patient Monitoring System

The Johns Hopkins Medical Institutions, Division of Cardiology and The Johns Hopkins Applied Physics Laboratory have developed medical procedures and associated telehealth system capabilities for the home monitoring and disease management of high risk outpatients suffering from congestive heart fail...
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Field-Portable Time-of-Flight Mass Spectrometer System

A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectromete...
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Improvement in Performance of a Microchannel Plate Detector Assembly Using a Miniature Anode (Micro-node)

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Information Technology in Support of Early Detection of Bioterrorist Events

Recent history demonstrates that weapons of mass destruction can be built and deployed by almost any individual or group that has an intent to cause harm or that is looking for media attention for its cause. The arsenal of weapons available to the terrorist includes chemical and biological agents. T...
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Low Pressure Electronically Controlled Valve

low-pressure valve enabling precise control of a fluid flow rate through the valve during cyclical operation of the valve. The valve is useful for controlling air delivery to a patient as part of a portable ventilator. The valve comprises a housing having an inlet 16 and two outlets 18 and 20. A wi...
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Clinician's Portable, Digital, Intelligent Assistant (Pain Informatics Program)

The input devices are mobile pen-based computers and palm pad systems that will emulate and expand the clinician’s present paper patient system. The system will provide for semi-automation of the collection, archiving, and retrieval of patient information. The Pain Informatics system provides medica...
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Assessment of Tooth Structure Using Laser Based Ultrasonics

Dental health care and research workers require a means of imaging the structures within teeth in vivo. For example, there is a need to image the margins of a restoration for the detection of poor bonding or voids between the restorative material and the dentin. With conventional x-ray techniques, i...
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Device for Rendering an Injection Syringe Single-Use Only

single-use, self-annulling syringe is disclosed that is rendered inoperative after a single use without requiring any deliberate action on the part of the user. The injection device uses a hydrophilic expansion plug positioned in the outlet flow channel of the syringe, which expands a short time af...
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Database and Knowledge-base Enhancements

Healthcare costs continue to escalate at a steep rate. Cost increases have occurred in all areas, including insurance premiums, medical equipment, medicines and costs for visits to doctors. A great deal of energy has gone into finding ways to reduce healthcare costs, from government control of aspec...
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Cross-hatched, focused, x-ray scatter reduction grid fabricated by lamination technique

An X-ray scatter reduction grid includes a first layer having a plurality of cells. The cells have a perimeter formed of an X-ray absorbing material. The shape of the perimeters can vary, but a polygonal shape is preferred. The grid can also include other layers, each with their own cells. The cells...
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A Gridless, Focusing Ion Source for a Time-of-Flight Mass Spectrometer

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Catalytic Inhibitor for Use in Anhydrous Ammonia to Counter Illicit Drug Manufacture

A method of inhibiting or preventing the use of anhydrous ammonia as a solvent in a dissolving metal reduction process comprises adding to anhydrous ammonia a chemical reagent which is capable of scavenging solvated electrons generated when alkali or alkaline earth metal is dissolved in the anhydrou...
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Rapid Chest Tube Inserter

Current chest tube insertion techniques are lengthy and require extensive training and experience. The Rapid Chest Tube Inserter enables a simple, rapid and safe insertion of a chest tube (or other types of drains) that is firm and stable. This technology extends the ability to insert the chest tube...
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Simple and Modular Reflectron Construction Using Flexible Circuit Board Material

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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DEXA Scanner System

A light weight, high resolution and precision, dual energy X-ray absorptions scanner for determining bone geometry and mass is needed. Inventors at the Johns Hopkins University Applied Physics Laboratory have developed a scanner that will be suitable for traditional and spaceflight uses requiring...
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Eye Fixation Monitor and Tracker

Apparatus and method are provided for assessing the direction of fixation of an eye by detecting polarization-related changes in light retroreflected from the fundus of the eye. Nerve fibers in the retina of the eye are birefringent and alter the polarization state of light traversing them as functi...
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Vestibular Irrigator Test System (VITS)

Caloric tests that irrigate the inner ear are often used as a first "reflex" type diagnostic when patients complain of dizziness (dizziness being the second most common cause of visits to general practices). The current caloric tests often require more than 1/2 hour to execute and the patients often...
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Emergency Life Support System

The invention comprises an emergency life support system including a patient ventilator for mechanical breathing assistance. The preferred embodiment uses an oxygen generator to deliver oxygen, to generate electric power to run the ventilation system, and to warm IV fluids and resuscitated air. ...
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Noninvasive Magnetic Sensing of Human Prostate Tumor

Despite the ability of noninvasive electromagnetic bioimpedance methods to measure low contrast changes in tissue, a perennial problem has been the precise localization of the change. Generally, the interrogation or sampling volume is gauged by the diameter of the coil used to impart the electrical ...
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Immunoaffinity Fluorometric Biosensor

The Immunoaffinity Fluorometric Biosensor is a hand-held, self-contained, automatic, low-power and rapid sensor platform for detecting and quantifying a plurality of analytes. This sensor platform (with the appropriate modifications) has been used to detect low levels of NADH; poly aromatic hydro...
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Video Ophthalmoscope with Single-Adjustment Focus

The invention is a hand-held ophthalmoscope modified by the removal or augmentation of the focusing wheel and the addition of a manual or automatic focusing lens system. An electronic imager (CCD array or video camera) is placed optically conjugate to a viewing screen such that focus operations perf...
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Friction Transmission with Axial Loading and a Radiolucent Surgical Needle Driver

Conventional needle driving techniques are based on holding the needle head and not the barrel of the needle, the motion of the needle being induced by moving the support of the needle head. The above technique does not allow radiolucent constructions. Moreover, supporting the needle from its head t...
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Intravenous Feed Anchor System (IVFAS)

IV treatment, administered on an inpatient or outpatient basis, is often interrupted by unintentional movement, blockage or removal of the IV from the patient. These very serious interruptions often create force on the IV supply line and can result in loss of IV dispensed fluids disrupting patient c...
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Passive Method to Objectively Quantify the Level and Density of a Neural Blockade

A critically important factor in current surgical/medical device design is the market demand for minimally invasive or non-invasive procedures. APL’s invention addresses that market need. From the issued patent Electromyogram (EMG), temperature, and heart rate measurements, which correlate to the...
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Optimization of Radiation Treatment Planning

An algorithm applied in the radiological treatment of tumors that minimizes a cost function that is quadratic in the residual between the prescribed dose distribution and the calculated resultant dose. Possible treatment arcs must be stipulated and the algorithm includes an automatic technique for m...
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Methods and Apparatus for Improved Visualization of Choroidal Blood Flow and Aberrant Vascular Structures in the Eye

There is very little information about the blood flow through capillary plexuses which occurs on the time scale of the cardiac cycle. In part this is because direct visualization of such plexuses usually is technologically difficult or impossible, and most blood flow measurement methodologies requir...
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Optical Feature Extraction Apparatus and Encoding Method for Detection of DNA Sequences

APL engineers have developed an optical imaging device that uses video display, spatial light modulation, and detection components, in conjunction with microlenslet replicating optics, to expedite the recognition of symbol sequences based on their symmetrical properties. Multichannel operation is ac...
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Method and System for Automated Detection of Microcalcification Clusters in Mammograms

The invention is a novel method for automated detection of objects in images. One specific use is to detect malignant microcalcification clusters in mammograms. The method operates by forming a contour plot of the image (mammogram), the object (microcalcification) in the contour plot being comprised...
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Method and Apparatus to Identify and Treat Neovascular Membranes in the Eye

Associated with a number of pathological conditions is the growth of ocular neovascular membranes. These membranes are often in close proximity to the sensory retina of the eye. If the abnormality arises from the retinal vessels, it is called a retinal neovascularization. If it is from the choroidal...
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Bone Substitute for Training and Testing

Training and testing of orthopaedic procedures and devices. This material can be used as a non-Biohazard replacement for real bone and can be manufactured to provide consistent performance. Can be used to develop and test new procedures, devices, and tools for use on bone. Based on the failure to...
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Automatic Detection of Seizures Using Electroencephalographic Signals

patient monitoring system and a method of activating it were developed. The system automatically detects a seizure in the patient by detecting an electrical discharge in the patient's brain. It then converts the detected electrical discharge into a digital signal and inputs the signal into a microp...
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Minimum Interface Biomedical Monitoring System

The present invention is a universal interface allowing a main implant to supply power and receive data from remotely implanted sensor modules through a minimum number of interconnecting lines. The main module can supply a single DC voltage, two sequentially applied DC voltages, or an AC voltage to ...
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Non-Invasive Electromagnetic Technique for Monitoring Physiological Changes in the Brain

None of the previous technologies contemplate measuring localized impedance changes in the brain to evaluate physiological changes in the brain, such as the occurrence of edematous tissue, and none of the references teach an apparatus capable of such spatially localized impedance measurements. A...
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Vascular Averting Instrument

The invention concerns a means having two instruments for averting an end of a severed artery over a ferrule surrounding the artery. A handle of a flaring instrument is squeezed to rotate a head section. Arms mounted to the head section open in the manner of an iris-diaphragm mechanism to flare the ...
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Apparatus for Inhibiting Self-Injurious Behavior (SIB) in Patients

An improved apparatus for inhibiting self-injurious behavior (SIB) in patients includes a stimulus module for generating and applying an aversive electrical stimulation to the patient's skin and a sensor module and/or remote actuator for actuating the stimulus module in response to a patient's self-...
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Prosthetic Elbow with a Motor-driven Release Mechanism

The invention concerns a releasing means for a prosthetic elbow locking mechanism. When an elbow unlocking cable is tensed by the amputee, a switch is closed, triggering a one-shot circuit. The one-shot circuit emits a single pulse, which drives the motor of the prosthetic elbow, turning the motor a...
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Method for Clearing a Gas Bubble from a Positive Displacement Pump Contained within a Fluid Dispensing System

A method and apparatus for removing gas bubbles from the fluid handling system of a medication infusion system are disclosed. Specifically, the invention discloses a method for removing fluid and/or gas bubbles from a fluid reservoir and pumping chamber. The present invention utilizes a fluid pump o...
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Single Valve Diaphragm Pump with Decreased Sensitivity to Ambient Conditions

A single valve diaphragm pump is disclosed which generally includes: a pump housing, a flexible diaphragm reciprocally movable in the pump housing, an inlet filter means, and an outlet valve. The flexible diaphragm conforms in shape to a portion of the pump housing when the diaphragm is in its actua...
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Manually Actuated Hydraulic Sphincter

An implantable hydraulic urinary sphincter system is disclosed for maintaining continence in those patients unable to control or stop inadvertent urinary flow. The invented apparatus generally consists of an artificial urinary sphincter and a control means for automatically increasing or decreasing ...
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Plural Module Medication Delivery System

The invention is a system consisting of a multiplicity of separate modules, which collectively perform a useful biomedical purpose, the modules communicating with each other without the use of interconnecting wires. All modules may be intracorporeal or body-mounted extracorporeal, or some modules ma...
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Self-Injurious Behavior Inhibiting System

An apparatus for preventing self-injurious behavior in patients is disclosed. The apparatus generally contains one or more sensor modules, which detect self-injurious blows, and a separate stimulation module, which produces an aversive electric stimulation. The sensor module and stimulation module a...
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Electro-Optical Device for Monitoring Instantaneous Singlet Oxygen Concentration Produced During the Treatment of Cancer

A method and apparatus are disclosed for optically monitoring the concentration of singlet oxygen produced during photoradiation. A composite optical emission in the 1.27 micron frequency band is detected and electrically processed to separate a first component due to the decay of singlet oxygen fro...
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Antifomitic Portfolio (736)

Abstract: Infection transmitted by contamination of objects in everyday use may be combated by periodic sterilization of such objects, as with ultraviolet sterilization lamps, or alternatively by covering them with cleanable or disposable protective barriers. Sterilization is impractical or insuffi...
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Sterilization Portfolio ()

Abstract: Sterilization by UV radiation is well known, working by attacking the DNA of microorganisms. UV below about 200 nm will also cause the generation of small amounts of ozone, an additional means of sterilization. However, most commercially available germicidal lamps operate on mercury vapor...
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Endothelium Preserving Microwave Treatment for Atherosclerosis (MSC-22724)

Abstract: The technology is for the non-surgical repair of diseased coronary arteries by interventional cardiologists during coronary catheterization. It is potentially safer than balloon angioplasty and other prior art. The device delivers millimeter / microwave energy by way of a catheter to prec...
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Non-Invasive, In-Vivo Bubble Sizing Instrument (MSC-22980)

Abstract: This invention is a non-invasive, in-vivo instrument for detecting, classifying, and sizing gaseous emboli. Gaseous emboli are nitrogen bubbles that travel through the human circulation system and eventually obstruct blood flow. This technology is capable of distinguishing between gaseous...
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Body Fluids Monitor (MSC-22491)

Abstract: This invention relates to a process and apparatus for determining amounts of body fluids in a subject using bioelectrical response. Based on circuit components, the total volume of body water, the volume of extra-cellular water, the total blood volume and the total plasma volume of a subj...
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Whole Blood Staining Device (MSC-22614)

Abstract: The Whole Blood Staining Device is a hand-held, self-contained device which provides a means to stain white blood cells by using monoclonal antibodies conjugated to various fluorochromes, followed by lysing and fixing the cells using a diluted commercial reagent. It provides a means to st...
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Subversion of Bacterial Resistance by Low Solubility Antibiotic

BACKGROUND: Resistance to antibiotic treatment is increasingly common. Current strategies to overcome resistance include combination therapy with multiple classes of antibiotics, concurrent treatment with immunomodulating drugs or resistance inhibitors, or a mixture of these strategies. This inventi...
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Monoclonal Antibody

Abstract (Set) A rat hybridoma producing a high-affinity IgG2a monoclonal antibody (B3B4) directed against the murine lymphocyte IgE receptor (FcR) was established by using purified FcR from FcR+ murine hybridoma B cells as immunogen. The monoclonal and polyclonal anti-FcR inhibited the binging of ...
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Use of Retinoic Acid

Proliferation of retinal pigment epithelium following surgery or trauma is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR) agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is al...
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Recombinationally-targeted cloning in Saccharomyces cerevisiae artificial chromosomes

Homologous recombination techniques are used to produce yeast artificial chromosomes (YAC) containing foreign target DNA by utilizing at least three DNA segments which yield the vector. Preferred embodiments allow the production of viral DNA which is infectious....
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Microencapsulation of Living Cells By Biopolymers

The invention relates to living cells encapsulated in a membrane. The membrane is a complex formed by the cohesion of two polymer layers. An inner layer comprises a substrate biopolymer and an outer layer comprises a synthetic polyelectrolyte having an electrolytic charge opposite that of the substr...
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Biodegradable, timed release cytokine depots: a new approach in cancer vaccine design

Experimental studies have demonstrated that potent systemic immunity can be generated using tumor vaccines engineered by gene transfer to secrete cytokines. The physiologic principle behind these strategies involves the sustained release of high doses of cytokine local to the tumor. In some cases, t...
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A Method for Designing Optimum MRI Pulse Sequences for Imaging Oblique Planes

Straightforward method to calculate maximum gradient amplitudes for the functions of frequency encode, phase encode, and section select in oblique MRI. The calculated amplitude values depend on the angulation of the prescription, and on which of the three functions are simultaneously active. The der...
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A Method of Operation for the Quadrupole Ion Trap in the Resonance Ejection Mode with Linear Dependence of the mlz Ratio of Ejected Ions upon the Trapping RF Voltage

A method for producing precise linear mass calibration and accurate mass measurements in the resonance ejection mode of an ion trap mass spectrometer using modulation of the endcap voltage amplitude proportional to the amplitude of the fundamental RF frequency....
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Algorithm for Predicting Protein Structure

Abstract (Set) Computer assisted method for predicting the 3-D structure of a protein fragment from its amino acid sequence utilizing folding hierarchy and localized energy functions. Description (Set) Proposed Use (Set) Accurate protein structure modeling is of use in the development of diag...
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Method of and Apparatus for Sanitizing MRI Machines

Abstract (Set) Since the advent of MRI exam reimbursement cut-backs, the motivation for increased patient volumes is becoming commonplace. In addition, a wider range of patients with various medical ailments and medical histories including Leukemia, Sacoidosis, AIDS, Lymphoma, Cancer, Tuberculosis,...
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Biomarkers for Pancreatic and Biliary Cancers

Abstract (Set) Pancreatic and biliary cancers are two of the most fatal among all human malignancies. Late presentation of the disease and lack of diagnostic markers are the major reasons for a dismal outcome of these cancers. The most widely used diagnostic marker for biliary and pancreatic cancer...
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Genome-wide Direct Transcription Measurement using Array-based Assay of Labeled Nascent RNA

Description (Set) JHU scientists have developed, optimized and validated an innovative approach for study of nascent RNA transcription. Post-transcriptional regulation of gene expression constitutes critical and wide-spread mechanisms. However, only ongoing transcription accurately reflects momenta...
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A Method for Monitoring Protein S-Nitrosylation

S-nitrosylation is the addition of a nitric oxide group to a cysteine group in a protein sequence to form an S-nitrosothiol derivative. JHU scientists developed a method in which a test sample comprising at least one protein substrate is treated with an alkylthiolating agent to block free thiol gro...
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Anti-HIF-1B Antibodies

Polyclonal antibodies were raised in rabbits and monoclonal antibodies were raised in mice that recognize hypoxia-inducible factor-1? Description (Set) Proposed Use (Set) These antibodies can be used for biomedical research to detect expression of HIF-1�in immunoblot, immunoprecipitation, and ...
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Anti Qa-1 Monoclonal Antibodies

Dr. Soloski's laboratory has been interested for a number of years in the function of non-polymorphic class Ib molecules. For the last few years we have focused on the murine non-polymorphic molecule Qa-1b encoded by the gene H2-T23. The "b" superscript represents the particular allele of Qa-1 recog...
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Coordinate independent, consistent and high level dual-gene transgenesis from a single lentiviral vector

Expression of multiple genes within the same target cells is required for certain gene delivery and therapeutic applications. In spite of such need, reaching independent, coordinate and high level dual-gene expression is still a challenging task. Non -uniform transfer, promoter interference, and poo...
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Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell sourc...
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Coordinate independent, consistent and high level dual-gene transgenesis from a single lentiviral vector

Expression of multiple genes within the same target cells is required for certain gene delivery and therapeutic applications. In spite of such need, reaching independent, coordinate and high level dual-gene expression is still a challenging task. Non -uniform transfer, promoter interference, and poo...
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Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device...
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Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering applic...
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Resorbable Laminated Repair Membrane for Accelerated and Sustained Wound Repair

Tracheal epithelial cells were cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. Technologies no. 5546 and 5558 studied how bio-degradable polymers and degradation proc esses could be used in replanting tracheal epithe...
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Choreographed, Active Protein Delivery from Biodegradable Devices

Tracheal epithelial cells were earlier cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. Technologies no. 5546 and 5558 studied how bio-degradable polymers and degradat ion processes could be used in replanting trachea...
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High Throughput Spectro Fluorimetric Screen for Drug Binding to Human Serum Proteins

This invention describes an improved method for determining the binding properties of drugs to human serum (human serum albumin (HAS) and alpha-1 acid glycoprotein (AAG). It uses spectrofluorimetry and works by measuring the effect of the drug on the fluorescence spectra of the human serum. The resu...
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Novel breakable crosslinkers and pH-responsive star-shaped and gel polymers

This invention describes a method for the preparation of novel crosslinkers and their application to star-shaped or branched polymers and polymer gels. The polymers can be easily changed to linear co-polymers and exhibit different properties in acid ic or basic media. These polymers and polymer gels...
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Synthesis and Processing of degradable Fluorocarbon End-Capped Polymers and their uses as Biomaterials

Tracheal epithelial cells were earlier cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. This technology describes the synthesis of bio-degradable polymers and study of degradation processes to replant tracheal epithel...
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Method of Testing the Degradation of Polymeric Biomaterials

TA model that mimics epithelialized tracheal luminal surface as it exists was earlier described in technology no. 5413. Using the said model, this invention studies the reaction kinetics of bio-degradable polymers (Poly (Glycolic) Acid) using “Time o f Flight (ToF) Secondary Ion Mass (SIMS) spectrom...
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Composite Culture on in Vitro Model (3-dimensional) of Tracheal Lumen

Tracheal epithelial cells are currently not replenishable, if lost through chemical (drug) action, intubations or other means. This invention is the first model that mimics the tracheal lumenal surface as it exists and can be used as a research tool to develop implantable tissue in future. Possible ...
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Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The protrusion of loo...
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Resorbable Laminated Repair Membrane for Accelerated and Sustained Wound Repair

Tracheal epithelial cells were cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. Technologies no. 5546 and 5558 studied how bio-degradable polymers and degradation proc esses could be used in replanting tracheal epithe...
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Novel breakable crosslinkers and pH-responsive star-shaped and gel polymers

This invention describes a method for the preparation of novel crosslinkers and their application to star-shaped or branched polymers and polymer gels. The polymers can be easily changed to linear co-polymers and exhibit different properties in acid ic or basic media. These polymers and polymer gels...
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Synthesis and Processing of degradable Fluorocarbon End-Capped Polymers and their uses as Biomaterials

Tracheal epithelial cells were earlier cultured in vitro to yield a model that near-perfectly replicates naturally epithelialized tracheal lumen vide technology no. 5413. This technology describes the synthesis of bio-degradable polymers and study of degradation processes to replant tracheal epithel...
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Method of Testing the Degradation of Polymeric Biomaterials

TA model that mimics epithelialized tracheal luminal surface as it exists was earlier described in technology no. 5413. Using the said model, this invention studies the reaction kinetics of bio-degradable polymers (Poly (Glycolic) Acid) using “Time o f Flight (ToF) Secondary Ion Mass (SIMS) spectrom...
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Composite Culture on in Vitro Model (3-dimensional) of Tracheal Lumen

Tracheal epithelial cells are currently not replenishable, if lost through chemical (drug) action, intubations or other means. This invention is the first model that mimics the tracheal lumenal surface as it exists and can be used as a research tool to develop implantable tissue in future. Possible ...
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Composite Culture on in Vitro Model (3-dimensional) of Tracheal Lumen

Tracheal epithelial cells are currently not replenishable, if lost through chemical (drug) action, intubations or other means. This invention is the first model that mimics the tracheal lumenal surface as it exists and can be used as a research tool to develop implantable tissue in future. Possible ...
...

Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device...
...

Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell sourc...
...

Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering applic...
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Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a con...
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Cell line expressing functional alpha1D-adrenergic receptors

Introduction The alpha1D-adrenergic receptor (AR) is a major regulator of cardiovascular and central nervous system function. Targeting AR is thus of major interest to the pharmaceutical industry for developing new medicines to treat hypertension and neurological disease. However, it has been imposs...
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Receptor-Ligand Assay for orphan tyrosine kinase receptors

Summary Transmembrane receptors are proteins which are localized in the plasma membrane of eukaryotic cells. They mediate molecular signaling functions by binding specifically with an external signaling molecule (the ligand) which activates the receptor. Receptor activation in turn leads to an intra...
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Methods for Improved Viability of Cells at Low Temperature

Summary Discovery of the linkage between the expression of Trigger Factor, a protein of previously-unknown function, and resistance of living cells to cold-shock has led to development of methods that enable prokaryotic and eukaryotic cells to remain viable at temperatures at- or below which they wo...
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Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a con...
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Microfluidic Devices with Tunable Microtopography

Introduction Microfluidic devices are critical components of many biomedical and bioanalytical instruments and allow for probing chemical and physical phenomena at the micron scale. Most current microfluidic devices, however, have the inherent functional limitation that the cross-sectional channel g...
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Cyclic Nucleotide Phosphodiesterase Family 10 / PDE10

Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 PDE genes that are categorized into 11 families. Selective inhibitors against individual PDE familie...
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Screening for Drugs Targeting tRNA Synthetase

Introduction Dr Jonathan Gallant’s laboratory has developed biomaterials that identify specific tRNA deficiencies within cells. These biomaterials can be used to screen for compounds which inhibit tRNA synthetases, such as certain classes of antibiotics, as well as to ensure efficient protein expres...
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Automated laboratory system and analytical module

Our invention: Fast Lab Technology is a cornerstone in preventive and lower cost health care of USA Government program: http://www.codebuildingblocks.com/Michael/FastSpin Our technology intends to decrease time and cost of routine and esoteric tests and comprises some new engineering methods and...
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Thermal Responsive Iron Oxide Magnetic Nanoparticles

Introduction Stimuli-responsive materials and molecules have numerous possible applications in the biomedical/pharmaceutical field, as well as in biotechnology and the related industries. Smart conjugates, smart surfaces, smart polymeric micelles and smart hydrogels have all been studied for a varie...
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Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cel...
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Method of enhancing expression of recombinant proteins

Introduction Large scale production of industrially and medically important proteins is achieved using “expression systems”, whereby a gene encoding the protein of choice is introduced into a cell (e.g. yeast or bacterial) that is optimized for high-yield expression. Many proteins are poorly produc...
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Method for Generating Human Retinal Neurons and Photoreceptors from Embryonic Stem Cells

Introduction The degeneration of neurons and photoreceptors in the retina occur in a number of disorders for which there are currently few therapies, including retinitis pigmentosa, age-related macular degeneration, and glaucoma. Although retinal regeneration is robust in lower vertebrates, regenera...
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Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse h...
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Programmable Generation and Transport of Droplets on Microscale Generation and Transport of Droplets on Microscale

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively...
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Three-dimensional (3-D) Thin-Film Microbattery

The Invention Alasan is a novel bioemulsifier produced by the microorganism Acinetobacter radioresistens KA53. It is a high molecular weight complex composed of an anionic polysaccharide containing a significant % of covalently bound alanine and four proteins. The Need Emulsifiers are used wi...
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Novel Antimicrobial Peptides

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY ...
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Exciplex™ a Highly Sensitive Nucleic Acid Fluorescent Detection System

BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The small Stokes shift (difference between excitation and emission wavelengths) often requires optical filte...
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3-D Self-assembled Peptide Hydrogels

BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extracellular matrix interactions. Self-assembling peptides, with the various properties of amino acids ...
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Biodrug Delivery Mechanism Via Yeast Encapsulation

BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically engineered yeast strain, able to express recombinant protein drugs / vaccines and incorporating a g...
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Shp-2 Tyrosine Phosphatase and Embryonic Stem Cell Differentiation

Shp-2 Tyrosine Phosphatase and Embryonic Stem Cell Differentiation...
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Apparatus and Method for Optical Detection of Seizures and Cerebral Edema

Background: Currently seizures are detected from deep brain structures with the use of electroencephalography (EEG). EEG recordings are made through electrodes placed on the scalp, on the brain surface, or inserted deep in the brain. EEG works through amplification of minute voltage potentials gene...
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Photo-electric Device and Method for High Throughput Activation, Guidance and Poration of Targeted Cells with High Spatial Resolution

Background: In biomedical research, controlled modulation of physiological functions of various excitable cells such as skeletal, cardiac and neuronal cells is important. The information derived from activation of these excitable cells under different chemical environments can lead to the evaluatio...
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Fiber Optic Probe and Method for Optical Trapping, Ablation, Excitation and Detection of Microscopic Objects

Background: Manipulation of microscopic objects by laser methods has been used since the 1970s. Both laser tweezers (used to hold microscopic objects in place) and optical scissors (used to conduct delicate surgery on the object in question) allow the scientists and engineers to perform minimally i...
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Method and Apparatus for Performing Qualitative and Quantitative Analysis of Wounds Using Spatially Structured Illumination

Background: Use of instruments to assess etiology and status of chronic wounds is still in an embryonic state. Clinicians rely primarily on clinical features such as wound size, location, depth, and infection in order to make treatment decisions regarding the patient care. Several array of medical ...
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Novel Antenna Angiography Catheter

Background: Cardiac catheterization is typically performed with stiff-tipped catheters. In order to engage a blood vessel orifice, the stiff tip must be positioned at a precise location, and in the correct orientation. During the relatively extensive manipulation sometimes required for target vesse...
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Fast Lysis Cell Traps

Background: Chemical cytometry involves the use of high-sensitivity analytical tools, such as mass spectrometry, electrochemistry and capillary or microfluidic separation methods to characterize single cells. In order to accomplish this analysis, it is desirable to selectively apply cells to predet...
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A Device and Method to Remove Excess Glucose in the Small intestine for Prevention and Treatment of Type 2 Diabetes and Obesity

Background: Type 2 Diabetes, also known as non-insulin dependent diabetes mellitus (NIDDM) or adult-onset diabetes is the most common form of diabetes affecting 90-95% of the 21 million Americans diagnosed with the disease. While traditionally diagnosed in adults over the age of 40, it is increasin...
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Magnetic Resonance Compatible Electric Motor

Background: Standard electrical motors when used in magnetic resonance (MR) instrumentation may interfere with the functionality of the MR imaging. These interferences from the motor distort the resulting MR images. Developing a motor that operates in high magnetic fields used in MR imaging and MR ...
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Continuous Reciprocal Flow in a Microfluidic Device for Efficient Mixing

Background: In certain microfluidic devices, continuous mixing of fluids is desirable depending on the application. For example, in the conventional or passive hybridization method, a DNA microarray is placed in solution where the immobilized single stranded DNA probes hybridize with complementa...
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Nanosecond Laser Cell Lysis in Microfluidic Devices

Background: To date, cell lysis in microfluidic devices for analytical purposes has been achieved using chemical, electrical, and optical means. Chemical cell lysis occurs on time scales of several to tens of seconds and is adequate for analytes whose chemical states change on such time scales. How...
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Safer Endotracheal Tube Cuff Pressure Regulation System

Background: The means to regulate endotracheal tube cuff pressure have been proposed in order to decrease the incidence of post-intubation complications caused by cuffed endotracheal tube. The regulation of endotracheal tube cuff pressure in prior art is achieved via a complex external pressure reg...
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Construction of Single Molecule Electronic Devices, with Applications to Biosensing

Background: "Molecular Electronics" (ME) generally refers to a class of novel electronic devices in which the electronic response and function are entirely controlled by single molecules. In principle, a wide range of devices can result from the incorporation of different types of molecules (e.g. m...
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Micromachined Passive Programmable Drug Delivery Systems

Background: The ability to deliver drugs locally to the site of need and over a prolonged period of time is important as a therapeutic method for many ailments and diseases. Many drugs are more effective if delivered at a specific site since they can be delivered in concentrated dosages at the poin...
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Soft Tissue Dissector

Background: Laparoscopic surgery has become part of the standard armamentarium for many urologic surgeons. Currently a wide variety of instruments are used to facilitate dissection during laparoscopic surgery. Each time a different instrument is used, it requires removal and reinsertion. Over the c...
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Non-scattering Oxygen Carrying Media for Intravascular Optical Coherence Tomography Imaging

Background: If blood is replaced locally in the vascular system by injection of saline solutions, OCT images can be obtained for brief periods of time, but lack of oxygen is deleterious to the tissues, and ischemia and damage will result, compromising patient health, as well as the OCT images obtai...
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An Integrated Microfluidic Platform with Lateral Dielectrophoresis (DEP) Based Cell/Particle Separation

Background: Most of the current techniques used for Dielectrophoresis separation use planar electrodes which sit at the bottom of the channel. With this design the electric field decreases dramatically as the height increases. Correspondingly, the gradient of the electric filed which is denoted as ...
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Portable Load Monitoring Device for a Patient"s Foot

Background: Subsequent to a variety of medical procedures including, but not limited to knee arthroplasties, hip arthroplasties, and fracture repairs, post-operative weight-bearing on the affected leg must be limited to facilitate proper healing and avoid exacerbation of injury. However, some degre...
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A Method and Apparatus to Inactivate Stem Cell Nuclei

Background: Stem cells may hold the key to future cures for many diseases. These are embryonic cells that are thought to have the potential to develop in any kind of tissue: liver, kidney, brain, etc. There is great scientific, medical, and economic interest in any technology that can facilitate th...
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Generation of Stable Concentration Gradients in 2D and 3D Environments Using a Microfluidic Ladder Chamber

Background: In the chemical, biomedical, and pharmaceutical industries, it has become increasingly desirable to perform large numbers of chemical operations in a highly parallel fashion. For example, cell culture methods are a commonly used research techniques that allows the systematic manipulatio...
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A Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same

Background: In many neurodegenerative diseases and in spinal cord injury, axons and synapses are damaged; a cell culture model is useful for investigation into these areas of research. In typical cell culture it is difficult to distinguish axon from dendrite, and fairly impossible to simulate micro...
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Use of Optical Coherence Tomography (OCT) for Use of Comprehensive Intra-oral Diagnosis

Background: In dentistry there exists a pressing need for novel diagnostic modalities. A strong consensus for reducing patient exposure to ionizing radiation is countered by the absence of other non-invasive diagnostic and monitoring tools. Diagnostic options for soft tissue pathologies are also li...
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Formulation of Monodisperse Contrast Agents in Microfluidic Systems for Ultrasonic Imaging

Background: Ultrasound imaging may be used to produce a 2D image of the body's internal structures. However, since blood is much less (1000x less) echogenic than tissue, small vessels, blood pool volume and blood flow all are difficult, if not impossible, to image using traditional ultrasound techn...
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Rapid Multiplex Gene and mRNA Detection in Picoliter Droplets by Molecular Beacons

Background: Breast cancer is a world wide public health concern and the estimated death toll in the U.S. in 2001 was 20,000 and it also ranked first as the cause of cancer death for women between the ages of 20 to 59. People carrying a mutation in the BRCA1and BRCA2 genes are prone to breast cancer...
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Microfluidic Production of Monodispersed Submicron EmulsionsThrough Filtration and Sorting of Satellite Drops

Background: In the past decade, droplets have been intensively used by the industries as an agent for drug preparations, for plastic polymerizations, and chemical processing. Recent advancements in microfluidic droplet technology has enabled the precise sampling and processing of small volumes of f...
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Wall-Less Microfluidics with On-Site Magnetohydrodynamic (MHD) Pumps for Continuous Flow Control

Background: A disadvantage of closed microfluidic channels are that they are made from different materials. Also, most of the microchannels are fabricated from lithography techniques which require the utilization of cleanroom environments, increasing the fabrication costs. Another disadvantage of t...
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Fiber optic bundle based optical coherence tomography

Background: Optical coherence tomography (OCT) has been used for high resolution optical imaging in many areas of medicine, especially ophthalmology. "Conventional wisdom" was that OCT could not be done through flexible fiber bundles. Indeed, the use of flexible fiberoptic bundles to deliver OCT di...
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Rapid Bio-Molecules Detection by Adjacent Impedance Probing (AIP) Techniques

Background: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, photoproteins, etc.) and the binding of these large molecules to their complementary molecular struct...
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Method of Fabrication of Self-enclosed Microchannels and/or Chambers with or Without Integrated Interconnects and Electrodes

Background: Conventional methods that create fluidic channels using photopolymers create channels and chambers by-coating, patterning, and developing each layer sequentially. These conventional methods of fabricating microchannels also involve using molds or patterning channels onto a flat substrat...
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Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood Vessels

Background: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means of treatment care for PWS and achieves effect by selectively targeting tissue vasculature. However, f...
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New Protein Resistant and Biodegradable Biopolymer

Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as the commonly used poly(ethylene glycol) (PEG) have been used in a number of applications such as pro...
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Top-Gate Carbon Nanotube Field Effect Transistor

Background: A carbon nanotube (CNT) is a one-dimensional molecular wire which is believed to have many potential applications in upgrading the density and performance of electronic information systems. Technology: This invention solves six potential problems with incorporating CNT's into next ge...
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A New Burr Design

Background: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty has significantly restricted the ability to do effective endoscopic surgery around the spine. Shield...
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New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle Circuit

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, VO2 and VCO...
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Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During Anesthesia

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, no accurate...
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A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory Prostheses

Background: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids and cochlear implants to ameliorate hearing loss have their disadvantages. Some of these include hi...
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Nanowires as Fast Chemical Sensors

Background: Recent years have witnessed a significant interest in biological applications of novel solid-state nanomaterials. The unique physical properties of molecular or nanoscale solids when utilized in conjunction with the biomolecular recognition capabilities could lead to miniaturization of ...
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Smart Probe with Station for Real Time, Non-Invasive Metrology of Microfluidic Chips

A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locations within a bio-fluidic chip. This station would allow for automated, high-throughput testing and ...
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Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the creation of macromolecular binding and catalytic sites and as binding sites for the separation or re...
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Prevention of Ice Formation on Tissue Surfaces Caused By Cooling During Laser Surgery

Background: A complication of using a cryogen gas to provide cooling during laser irradiation of biological tissues is the formation of ice crystals. This formation of ice on the tissue surface causes two major problems: 1) it decreases the incident light dosage due to optical scattering by the cry...
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Genes Encoding Telomere-Associated Proteins

APPLICATIONS OF TECHNOLOGY: - Molecular biology research - Medical research ABSTRACT: Telomeres are believed to be critical regulators of the genome, and telomere stability important for preventing cancer and ageing. Regulation of telomere length is believed to be controlled by multiple telomere...
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Full Karyotype Analysis for Increasing Pregnancy Rates per IVF Cycle

APPLICATIONS OF TECHNOLOGY: - Screening all 24 chromosomes for numeric chromosome abnormalities during Preimplantation Genetic Diagnosis - Diagnosing disease states requiring cytogenetic analysis - Monitoring the effects of accidental or occupational exposure to environmental hazards ADVANTAGES...
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Diagnostic MRI Skin Map Database

IB-2390 APPLICATIONS OF TECHNOLOGY: Using MRI data to develop a database that systematically characterizes skin properties Developing a skin map for a patient and comparing it to the database to determine the best treatment Using a patient’s MRI skin map data to determine the settings o...
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Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and Biopsy

APPLICATIONS OF TECHNOLOGY: Detects prostate cancer using accurately co-registered positron emission tomography (PET) and transrectal ultrasound (TRUS) images Guides prostate biopsy sampling Monitors response to treatment and detects local recurrence ADVANTAGES: Provides high-resolution...
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Method of Production of RNA Polymerase Protein

Abstract The invention relates to the production of protein 2a that can copy, in vitro, any RNA. The invention provides a method for obtaining a stable RNA polymerase enzyme by expressing protein 2a in cells, pelleting the cells expressing protein 2a, macerating the cells expressing protein 2a to ...
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Counter-Current Fluid-Fluid Flows Mixer (C2F3M)

The process of mixing fluids, or fluids and particulates, is critical in biology, chemistry, medicine, and engineering and in numerous applications involving the synthesis of pharmaceuticals, flows through biomedical devices, the fabrication of materials, the food industry, and contamination of the ...
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Novel High Volume Process for the Production of Silver Nanoparticles with Controlled Shape and Dimension (SilverFluidicsTM)

New Market Opportunity: Silver nanoparticles have applications in a wide number of fields across the electronics, physics, chemistry and biomedical fields. The optical absorption and fluorescence characteristics of the silver nanoparticles are critical to their functionality in all applications. Th...
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