A layer-by-layer deposition method for forming multiple layers of material onto the walls of a channel of a microfluidic device is disclosed. The method comprises: loading a tube with a series of segments of solution, a segment of solution bearing a material to be deposited; coupling the tube to the microfluidic device channel; and injecting the segments of solution into the microfluidic device using a syringe such that the segments of solution pass, in turn, through the channel depositing successive layers of material to perform layer-by-layer deposition onto the walls of the channel. The segments may be separated by water for rinsing the channel after deposition or air. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. Applications including inkjet printing, chemical or biochemical sensors, and lab-on-chip devices are disclosed.
BAUER WOLFGANG ANDREAS [DE]; HUCK WILHELM T S [NL]; FISCHLECHNER MARTIN [AT]
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